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Molecular Biology: Insertional Mutagenesis and Oncogenes

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Molecular Biology: Insertional Mutagenesis and Oncogenes

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Questions and Answers

What is the most common type of inherited cancer syndrome?

X-linked dominant

Mitochondrial inheritance

Autosomal dominant (correct)

Autosomal recessive

What is the result of non-lethal genetic damage in terms of cancer development?

Carcinoma

Cancer (correct)

Apoptosis

Leukemia

What is the relationship between oncogenes and protooncogenes?

Oncogenes are normal growth/differentiation genes

Oncogenes are CA-causing derivatives of tumor suppressors

Oncogenes are CA-causing derivatives of protooncogenes (correct)

Oncogenes are DNA repair genes

What is the most common type of cancer in terms of incidence in men?

Prostate Signup and view all the answers

What is the consequence of defective DNA repair genes?

Cancer Signup and view all the answers

What is the example of autosomal recessive syndrome of DNA repair?

Xeroderma pigmentosum Signup and view all the answers

What is the primary function of cyclin D in the cell cycle?

Phosphorylating Rb to release E2F Signup and view all the answers

Which of the following is a characteristic of oncogene activation?

Change in structure or regulation of a proto-oncogene Signup and view all the answers

What is the primary function of p53 in response to DNA damage?

Activating cell cycle checkpoints Signup and view all the answers

What is the term for the process by which tumor cells invade the ECM?

Invasion Signup and view all the answers

Which of the following is a characteristic of a malignant tumor?

Local invasion and metastases Signup and view all the answers

What is the term for the process by which tumor cells disseminate through the vascular system and home to specific organs?

Vascular dissemination and homing Signup and view all the answers