12 Questions
What is the most common type of inherited cancer syndrome?
Autosomal dominant
What is the result of non-lethal genetic damage in terms of cancer development?
Cancer
What is the relationship between oncogenes and protooncogenes?
Oncogenes are CA-causing derivatives of protooncogenes
What is the most common type of cancer in terms of incidence in men?
Prostate
What is the consequence of defective DNA repair genes?
Cancer
What is the example of autosomal recessive syndrome of DNA repair?
Xeroderma pigmentosum
What is the primary function of cyclin D in the cell cycle?
Phosphorylating Rb to release E2F
Which of the following is a characteristic of oncogene activation?
Change in structure or regulation of a proto-oncogene
What is the primary function of p53 in response to DNA damage?
Activating cell cycle checkpoints
What is the term for the process by which tumor cells invade the ECM?
Invasion
Which of the following is a characteristic of a malignant tumor?
Local invasion and metastases
What is the term for the process by which tumor cells disseminate through the vascular system and home to specific organs?
Vascular dissemination and homing
Test your understanding of insertional mutagenesis, where a virus inserts into a regulatory gene, and oncogenes that code for growth factors, signal transduction proteins, and cell cycle regulators. This quiz covers the role of cyclins, CDKs, and Rb protein in the cell cycle.
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