Modified Release Oral Drug Delivery

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What is the primary characteristic of delayed release dosage forms?

Releasing the drug at a specific pH level

Releasing the drug promptly after administration

Releasing the drug at a time other than promptly after administration (correct)

Releasing the drug in a slow and controlled manner

What percentage of medicines are delivered by the oral route?

70% (correct)

90%

100%

50%

What is the main difference between repeat action and extended release dosage forms?

The pH level at which the drug is released

The frequency of dosing

The rate of drug release (correct)

The number of doses released

What is the limitation of conventional oral dosage forms?

They produce therapeutic blood level peaks and valleys. Signup and view all the answers

What is the ideal situation in therapy?

Maintaining a constant drug concentration at the site of action. Signup and view all the answers

What is the term used to describe dosage forms that release the drug in response to environmental pH?

Gastro-resistant dosage forms Signup and view all the answers

What is the advantage of IV infusion over oral administration?

It allows for better control of drug concentration in the blood. Signup and view all the answers

What is the primary advantage of extended release dosage forms?

Reducing the frequency of dosing Signup and view all the answers

What is the result of the conventional oral dosage forms schedule?

Therapeutic blood level peaks and valleys. Signup and view all the answers

What is the term used to describe the timing of drug release to coincide with when it is required?

Chronotherapy Signup and view all the answers

What is the advantage of modified-release oral dosage forms?

They provide a constant drug concentration at the site of action. Signup and view all the answers

What is the primary characteristic of gastroretentive systems?

Releasing the drug in the stomach Signup and view all the answers

What is the primary purpose of a release-controlling agent in a modified release delivery system?

To regulate the release of the active drug from the dosage form Signup and view all the answers

What is a characteristic of hydrophilic colloid matrices in matrix delivery systems?

The drug particles are dispersed in a soluble matrix and become available as the matrix dissolves Signup and view all the answers

What is a type of modified release delivery system that uses an osmotic pump system?

Osmotic pump system Signup and view all the answers

What is the role of a solubilizer in a modified release delivery system?

To improve the solubility of the active drug Signup and view all the answers

What is the primary function of a lubricant in a modified release dosage form?

To facilitate the flow of powder during manufacturing Signup and view all the answers

What is the ideal rate of release of drug from the maintenance portion of the dosage form?

Zero-order rate Signup and view all the answers

What is the primary goal of the zero-order rate of release of drug from the maintenance dose?

To maintain the concentration of drug in the body at the required therapeutic value Signup and view all the answers

What is the characteristic of the kinetic pattern of drug release from the ideal modified controlled-release dosage form?

The rate of release is independent of the amount of drug remaining in the dosage form Signup and view all the answers

What is the consequence of a non-zero-order rate of release of drug from the maintenance dose?

Blood levels of the drug decrease with time until the next dose is administered Signup and view all the answers

What is the primary advantage of modified-release dosage forms in terms of patient compliance?

Reduced frequency of doses Signup and view all the answers

What is the common kinetic pattern of drug release from most currently marketed modified release formulations?

First-order process Signup and view all the answers

What is the primary purpose of floating dosage forms?

To avoid gastric emptying Signup and view all the answers

Which of the following is NOT a material used in size increasing systems?

Glassy amylose Signup and view all the answers

What is the pH range of the colon?

pH 7.8-8.5 Signup and view all the answers

Which of the following is an application of colonic delivery systems?

Local drug delivery for the treatment of inflammatory diseases Signup and view all the answers

What is the purpose of using a thick compression coat of pectin cross-linked with calcium in colonic delivery systems?

To allow the colonic bacteria to degrade the polymer Signup and view all the answers

What is the principle behind the use of pH-sensitive polymers in colonic delivery systems?

The polymers are sensitive to the pH of the colon Signup and view all the answers