Modified Release Oral Drug Delivery
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Questions and Answers

What is the primary characteristic of delayed release dosage forms?

  • Releasing the drug at a specific pH level
  • Releasing the drug promptly after administration
  • Releasing the drug at a time other than promptly after administration (correct)
  • Releasing the drug in a slow and controlled manner

    • What percentage of medicines are delivered by the oral route?

  • 70% (correct)
  • 90%
  • 100%
  • 50%

    • What is the main difference between repeat action and extended release dosage forms?

  • The pH level at which the drug is released
  • The frequency of dosing
  • The rate of drug release (correct)
  • The number of doses released

    • What is the limitation of conventional oral dosage forms?

    <p>They produce therapeutic blood level peaks and valleys.</p> Signup and view all the answers

    What is the ideal situation in therapy?

    <p>Maintaining a constant drug concentration at the site of action.</p> Signup and view all the answers

    What is the term used to describe dosage forms that release the drug in response to environmental pH?

    <p>Gastro-resistant dosage forms</p> Signup and view all the answers

    What is the advantage of IV infusion over oral administration?

    <p>It allows for better control of drug concentration in the blood.</p> Signup and view all the answers

    What is the primary advantage of extended release dosage forms?

    <p>Reducing the frequency of dosing</p> Signup and view all the answers

    What is the result of the conventional oral dosage forms schedule?

    <p>Therapeutic blood level peaks and valleys.</p> Signup and view all the answers

    What is the term used to describe the timing of drug release to coincide with when it is required?

    <p>Chronotherapy</p> Signup and view all the answers

    What is the advantage of modified-release oral dosage forms?

    <p>They provide a constant drug concentration at the site of action.</p> Signup and view all the answers

    What is the primary characteristic of gastroretentive systems?

    <p>Releasing the drug in the stomach</p> Signup and view all the answers

    What is the primary purpose of a release-controlling agent in a modified release delivery system?

    <p>To regulate the release of the active drug from the dosage form</p> Signup and view all the answers

    What is a characteristic of hydrophilic colloid matrices in matrix delivery systems?

    <p>The drug particles are dispersed in a soluble matrix and become available as the matrix dissolves</p> Signup and view all the answers

    What is a type of modified release delivery system that uses an osmotic pump system?

    <p>Osmotic pump system</p> Signup and view all the answers

    What is the role of a solubilizer in a modified release delivery system?

    <p>To improve the solubility of the active drug</p> Signup and view all the answers

    What is the primary function of a lubricant in a modified release dosage form?

    <p>To facilitate the flow of powder during manufacturing</p> Signup and view all the answers

    What is the ideal rate of release of drug from the maintenance portion of the dosage form?

    <p>Zero-order rate</p> Signup and view all the answers

    What is the primary goal of the zero-order rate of release of drug from the maintenance dose?

    <p>To maintain the concentration of drug in the body at the required therapeutic value</p> Signup and view all the answers

    What is the characteristic of the kinetic pattern of drug release from the ideal modified controlled-release dosage form?

    <p>The rate of release is independent of the amount of drug remaining in the dosage form</p> Signup and view all the answers

    What is the consequence of a non-zero-order rate of release of drug from the maintenance dose?

    <p>Blood levels of the drug decrease with time until the next dose is administered</p> Signup and view all the answers

    What is the primary advantage of modified-release dosage forms in terms of patient compliance?

    <p>Reduced frequency of doses</p> Signup and view all the answers

    What is the common kinetic pattern of drug release from most currently marketed modified release formulations?

    <p>First-order process</p> Signup and view all the answers

    What is the primary purpose of floating dosage forms?

    <p>To avoid gastric emptying</p> Signup and view all the answers

    Which of the following is NOT a material used in size increasing systems?

    <p>Glassy amylose</p> Signup and view all the answers

    What is the pH range of the colon?

    <p>pH 7.8-8.5</p> Signup and view all the answers

    Which of the following is an application of colonic delivery systems?

    <p>Local drug delivery for the treatment of inflammatory diseases</p> Signup and view all the answers

    What is the purpose of using a thick compression coat of pectin cross-linked with calcium in colonic delivery systems?

    <p>To allow the colonic bacteria to degrade the polymer</p> Signup and view all the answers

    What is the principle behind the use of pH-sensitive polymers in colonic delivery systems?

    <p>The polymers are sensitive to the pH of the colon</p> Signup and view all the answers

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