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Modified-Release Drug Delivery in Healthcare

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Modified-Release Drug Delivery in Healthcare

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Questions and Answers

What is the main difference between insoluble polymer matrix systems and hydrophilic matrices?

Insoluble polymer matrices dissolve in water, while hydrophilic matrices do not.

Insoluble polymer matrices have zero-order kinetics, while hydrophilic matrices do not.

Insoluble polymer matrices stay intact in the gastrointestinal tract, while hydrophilic matrices do not. (correct)

Insoluble polymer matrices release drug molecules through the membrane, while hydrophilic matrices do not.

Why is pore size and tortuosity important in controlling the drug release rate in insoluble polymer matrix systems?

Pore size and tortuosity determine the color of the matrix.

Pore size and tortuosity impact the weight of the matrix tablet.

Pore size and tortuosity affect how drug molecules diffuse out of the matrix. (correct)

Pore size and tortuosity regulate the temperature at which drug release occurs.

How does the presence of membrane differ between membrane-controlled systems and insoluble polymer matrix systems?

Membrane-controlled systems have a higher tortuosity than insoluble polymer matrices.

Membrane-controlled systems rely on a membrane for drug diffusion, while insoluble polymer matrices do not use a membrane. (correct)

Membrane-controlled systems release drugs via pores, unlike insoluble polymer matrices.

Membrane-controlled systems have drug molecules dispersed throughout the matrix, while insoluble polymer matrices do not.

Why does drug release from insoluble polymer matrix systems not follow zero-order kinetics?

Drug molecules have to travel increasing distances to reach the surface of the device over time. Signup and view all the answers

What role do pore forming agents play in insoluble polymer matrix systems?

Pore forming agents increase tortuosity to facilitate drug release. Signup and view all the answers

Which factor greatly influences the drug release mechanism in insoluble polymer matrix systems?

The method of drug dispersion within the system Signup and view all the answers

How does a dry insoluble matrix tablet differ from a wet one in terms of drug diffusion?

In a dry tablet, channels are hydrated allowing drug diffusion. Signup and view all the answers

What aspect does the rate-controlling part of membrane-controlled systems consist of?

A membrane through which the drug must diffuse Signup and view all the answers

How do membrane-controlled delivery systems differ from insoluble polymer matrix systems in terms of drug diffusion?

Drug diffusion occurs only via pores in membrane-controlled systems, unlike insoluble polymer matrices. Signup and view all the answers

What factors affect the control of drug release rate in insoluble polymer matrix systems?

Pore size and number of pores Signup and view all the answers

Why is it essential for insoluble polymer matrices to stay intact throughout the gastrointestinal tract?

To prevent drug leaching into the gastrointestinal tract Signup and view all the answers