11 Questions
What is the main difference between insoluble polymer matrix systems and hydrophilic matrices?
Insoluble polymer matrices stay intact in the gastrointestinal tract, while hydrophilic matrices do not.
Why is pore size and tortuosity important in controlling the drug release rate in insoluble polymer matrix systems?
Pore size and tortuosity affect how drug molecules diffuse out of the matrix.
How does the presence of membrane differ between membrane-controlled systems and insoluble polymer matrix systems?
Membrane-controlled systems rely on a membrane for drug diffusion, while insoluble polymer matrices do not use a membrane.
Why does drug release from insoluble polymer matrix systems not follow zero-order kinetics?
Drug molecules have to travel increasing distances to reach the surface of the device over time.
What role do pore forming agents play in insoluble polymer matrix systems?
Pore forming agents increase tortuosity to facilitate drug release.
Which factor greatly influences the drug release mechanism in insoluble polymer matrix systems?
The method of drug dispersion within the system
How does a dry insoluble matrix tablet differ from a wet one in terms of drug diffusion?
In a dry tablet, channels are hydrated allowing drug diffusion.
What aspect does the rate-controlling part of membrane-controlled systems consist of?
A membrane through which the drug must diffuse
How do membrane-controlled delivery systems differ from insoluble polymer matrix systems in terms of drug diffusion?
Drug diffusion occurs only via pores in membrane-controlled systems, unlike insoluble polymer matrices.
What factors affect the control of drug release rate in insoluble polymer matrix systems?
Pore size and number of pores
Why is it essential for insoluble polymer matrices to stay intact throughout the gastrointestinal tract?
To prevent drug leaching into the gastrointestinal tract
Explore the benefits of once-daily dosing, treatment of local gastrointestinal areas, topical treatment for conditions like inflammatory bowel disease, and site-specific drug targeting in healthcare. Learn what modified-release drug delivery means for health care professionals and the pharmaceutical industry.
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