Pharmaceuticals: Controlled-Release and Modified-Release Products
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Questions and Answers

What is the primary goal of controlled-release products?

  • To achieve and maintain optimum therapeutic blood levels of a drug (correct)
  • To reduce the frequency of drug administration
  • To prolong the duration of a drug's effects
  • To achieve rapid therapeutic blood levels of a drug
  • What is the most common route of administration for modified-release products?

  • Parenteral
  • Transdermal
  • Oral (correct)
  • Subdermal
  • What is a characteristic of non-oral rate-controlled drug delivery systems?

  • They are all administered through the skin
  • They have a fixed duration of drug release
  • They are only used for estradiol delivery
  • They have a variable drug-release pattern (correct)
  • Which of the following non-oral controlled-release delivery systems has the longest duration of drug release?

    <p>Levonorgestrel subdermal implants</p> Signup and view all the answers

    Which of the following is an example of a non-oral controlled-release delivery system?

    <p>Vaginal ring inserts</p> Signup and view all the answers

    Study Notes

    Controlled-Release Products

    • Designed to release medication in a controlled manner, at a predetermined rate, duration, and location to achieve and maintain optimum therapeutic blood levels of a drug.
    • The majority of modified-release products are orally administered, including tablets and capsules.

    Non-Oral Controlled-Release Delivery Systems

    • Include ocular, parenteral, subdermal, vaginal, and transdermal products.
    • Release patterns vary in duration, including: • 24 hours for most transdermal patches • 3 months for the estradiol vaginal ring insert (Estring, Pharmacia & Upjohn) • 5 years for levonorgestrel subdermal implants (Norplant System, Wyeth-Ayerst)

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    Description

    Test your knowledge on controlled-release and modified-release products, including their design, administration, and delivery systems. Identify the different types of products and their routes of administration, and understand the importance of achieving optimal therapeutic blood levels.

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