Models of Human Disease
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Questions and Answers

What is the purpose of using model organisms in studying human genetic diseases?

  • To identify disease genes and test therapeutic approaches in preclinical studies (correct)
  • To replace human subjects in clinical trials
  • To conduct clinical trials directly on model organisms
  • To manipulate human genetics directly for experimental purposes

    • Which gene, when nonfunctional, leads to obesity in both mice and humans?

  • The O b gene (correct)
  • The LEP gene
  • The PSMA gene
  • The CRISPR gene

    • What process is studied in Caenorhabditis Elegans to understand human neurodegenerative diseases?

  • Protein sequencing
  • Apoptosis (correct)
  • Gene editing
  • Metabolic pathways

    • Which organism shares virtually identical genes with humans related to body plans, organ development, aging, and death?

    <p>Fruit flies</p> Signup and view all the answers

    What tool is commonly used for editing genes in model organisms to study different diseases?

    <p>CRISPR-Cas</p> Signup and view all the answers

    Which type of biomarker typically involves proteins produced by diseased tissue or those with increased production in diseased tissues?

    <p>PSA (prostate-specific antigen)</p> Signup and view all the answers

    What method involves removing a small portion of the chronic villus to detect genetic diseases in the fetus?

    <p>Amniocentesis</p> Signup and view all the answers

    What is the significance of the Human Genome Project?

    <p>It identified genomic changes involved in a variety of cancers</p> Signup and view all the answers

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