16 Questions
What is meant by selective toxicity in relation to antibiotics?
Disrupting a structure or process essential for microorganism growth and survival
Why must antibiotics cause minimal harm to the host organism?
To ensure they are therapeutic but not excessively toxic
Which of the following is an essential requirement for antibiotics according to the text?
Causing disruption to a structure essential for microorganism growth and survival
Why is it important for some antibiotics to have a narrow therapeutic index?
To ensure they are therapeutic but not excessively toxic
Which scenario represents selective toxicity in antibiotics?
The antibiotic target is absent in human cells but present in the bacteria
What does therapeutic drug monitoring aim to achieve for some antibiotics?
Ensure they are therapeutic but not excessively toxic
Which structure/process is disrupted by cell wall active agents in bacteria?
Peptidoglycan synthesis
What is the mode of action of b-lactam antibiotics in bacteria?
Inhibiting transpeptidases
Which type of bacteria can produce enzymes that destroy the b-lactam ring of antibiotics?
Both Gram-positive and Gram-negative bacteria
What is the primary target of glycopeptides like vancomycin in bacteria?
Peptidoglycan synthesis
Which enzyme is inhibited by b-lactam antibiotics in bacteria?
Transpeptidase
What is the consequence of disrupting the process of peptidoglycan synthesis in bacterial cell walls?
Cell lysis
Which type of bacteria are affected by glycopeptides like vancomycin?
Only Gram-positive bacteria
What is the role of b-lactamase inhibitors in the presence of b-lactam antibiotics?
'Mop-up' b-lactamase enzymes
'Transpeptidases' are enzymes involved in the:
"Cross-linking of peptidoglycan structure in bacterial cell walls"
What is the primary target of glycopeptides like vancomycin in bacterial cells?
Peptidoglycan synthesis
Test your understanding of the mode of action of antimicrobials with this quiz. Explore the mechanisms of action of antibiotics and their selective toxicity, and learn about examples of antibiotics in major classes.
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