MLS 416 - Immunohematology Lecture F3
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Questions and Answers

What is the primary goal of adding additive solutions and anticoagulants to blood components during storage?

  • To enhance the viability and function of the blood component
  • To prevent bacterial contamination
  • To minimize physical changes in the blood component (correct)
  • To maximize the shelf life of the blood component

    • What is the main advantage of component transfusion over whole blood transfusion?

  • It allows for more efficient use of blood components (correct)
  • It enables more precise matching of blood types
  • It reduces the risk of transfusion-associated infections
  • It provides better preservation of blood viability and function

    • What is the primary concern in blood component preparation that can be addressed by the use of anticoagulants?

  • Prevention of clotting during transfusion (correct)
  • Prevention of physical changes during storage
  • Preservation of blood viability and function
  • Prevention of bacterial contamination

    • What is the primary benefit of optimizing blood component storage conditions?

    <p>Improved safety and efficacy of blood transfusions</p> Signup and view all the answers

    What is the primary goal of blood component preparation in the context of hemotherapy?

    <p>To maximize the usage of blood in component transfusion</p> Signup and view all the answers

    What is the primary concern addressed by the use of additive solutions in blood component preparation?

    <p>Prevention of physical changes during storage</p> Signup and view all the answers

    What is the primary purpose of adding additive solutions to packed RBCs?

    <p>To enhance red cell metabolism during storage</p> Signup and view all the answers

    What happens to plasma retention in packed red cells when additive solutions are not used?

    <p>More plasma is retained</p> Signup and view all the answers

    What is the primary concern during blood component preparation?

    <p>Time constraints</p> Signup and view all the answers

    Why is it important to separate blood components from whole blood?

    <p>To preserve autologous units and rare phenotypes</p> Signup and view all the answers

    What is the effect of additive solutions on ADP production during storage?

    <p>It increases ADP production</p> Signup and view all the answers

    What is the benefit of removing more plasma from packed red cells when using additive solutions?

    <p>Minimized storage hemolysis</p> Signup and view all the answers

    What is the primary function of anticoagulants in blood collection and storage?

    <p>To prevent the clotting process and maintain blood in a fluid state</p> Signup and view all the answers

    What happens when a blood component is transferred from one blood bag to another?

    <p>The blood component is now considered an open-system, reducing its allowable storage time</p> Signup and view all the answers

    What is the purpose of additive solutions in blood storage?

    <p>To allow for longer storage of blood, depending on the type of solution used</p> Signup and view all the answers

    What is the common issue with blood recording in the Philippines compared to other countries?

    <p>Manual recording, with some encoded in computer systems</p> Signup and view all the answers

    What happens to blood components that are contaminated with bacteria?

    <p>They are discarded due to the high risk of infection</p> Signup and view all the answers

    What is the primary concern when a blood component is exposed to air?

    <p>The risk of bacterial contamination</p> Signup and view all the answers

    What is the effect of decreased 2,3-DPG on red blood cells?

    <p>Decreases oxygen release</p> Signup and view all the answers

    Why is fresh blood necessary for exchange transfusion in newborns?

    <p>To ensure sufficient 2,3-DPG for oxygen release</p> Signup and view all the answers

    What is the purpose of citrate in anticoagulant solutions?

    <p>To chelate calcium and prevent coagulation</p> Signup and view all the answers

    What is the primary function of mannitol in additive solutions?

    <p>To prevent hemolysis by stabilizing the red blood cell membrane</p> Signup and view all the answers

    What is the effect of a low pH environment on red blood cells?

    <p>Destroys red blood cells</p> Signup and view all the answers

    What is the primary purpose of adenine in additive solutions?

    <p>To provide a source of energy for ATP synthesis</p> Signup and view all the answers

    What is the minimum percentage of original RBCs that must be supported in the recipient's circulation for at least 24 hours after transfusion?

    <p>75%</p> Signup and view all the answers

    Which of the following biochemical changes occur in the blood during storage?

    <p>Increased hemoglobin</p> Signup and view all the answers

    What is the byproduct of glucose metabolism that causes the pH to decrease during storage?

    <p>Lactic acid</p> Signup and view all the answers

    What is the primary source of sodium increase in stored blood?

    <p>Gradual breakdown of RBCs</p> Signup and view all the answers

    What is the purpose of ATP in stored red blood cells?

    <p>To support various cellular functions</p> Signup and view all the answers

    What is the maximum duration for which some red blood cells can survive during storage?

    <p>120 days</p> Signup and view all the answers

    What is the primary function of centrifuge equipment in blood component manufacturing?

    <p>To separate blood components from whole blood</p> Signup and view all the answers

    What is the main objective of following Current Good Manufacturing Practices (CGMP) in blood manufacturing?

    <p>To ensure the safety, purity, and potency of blood products</p> Signup and view all the answers

    What is the primary purpose of documentation in blood manufacturing?

    <p>To capture critical steps in the blood manufacturing process</p> Signup and view all the answers

    What is the primary concern addressed by the use of filtration in blood component manufacturing?

    <p>Contamination from one component to another</p> Signup and view all the answers

    What is the primary advantage of using plated agitator machines in blood component storage?

    <p>Improved anticoagulant and additive mixing</p> Signup and view all the answers

    What is the primary role of refrigerators in blood component storage?

    <p>To store blood components at optimal temperatures</p> Signup and view all the answers

    What is the primary purpose of anticoagulants in blood component preparation?

    <p>To prevent blood clotting</p> Signup and view all the answers

    What is the primary concern addressed by the use of additive solutions in blood component preparation?

    <p>Reduced blood component shelf life</p> Signup and view all the answers

    What is the primary role of storage freezers in blood component management?

    <p>To store blood components at ultra-low temperatures</p> Signup and view all the answers

    What is the primary benefit of implementing robust quality control measures in blood component manufacturing?

    <p>Enhanced safety, purity, and potency of blood products</p> Signup and view all the answers

    What is the primary function of adenine in additive solutions?

    <p>To act as a substrate for red cell ATP synthesis</p> Signup and view all the answers

    Why is it necessary to use fresh blood for exchange transfusion in newborns?

    <p>To ensure adequate 2,3-DPG levels for oxygen release</p> Signup and view all the answers

    What is the primary consequence of decreased 2,3-DPG levels in stored red blood cells?

    <p>Increased oxygen affinity and decreased oxygen release</p> Signup and view all the answers

    What is the primary function of citrate in anticoagulant solutions?

    <p>To chelate calcium and prevent coagulation</p> Signup and view all the answers

    What is the primary consequence of low pH environment on stored red blood cells?

    <p>Increased risk of hemolysis and reduced shelf life</p> Signup and view all the answers

    What is the primary purpose of additive solutions in blood storage?

    <p>To support ATP generation via the glycolytic pathway</p> Signup and view all the answers

    What is the primary mechanism by which ATP is utilized in red blood cells during storage?

    <p>To produce energy for cellular functions</p> Signup and view all the answers

    What is the primary consequence of decreased 2,3-DPG levels in red blood cells?

    <p>Increased oxygen release</p> Signup and view all the answers

    What is the primary biochemical change that occurs in stored blood, leading to a decrease in pH?

    <p>Lactic acid buildup</p> Signup and view all the answers

    What is the primary function of additive solutions in packed RBCs?

    <p>To reduce hemolysis</p> Signup and view all the answers

    What is the primary source of increased sodium levels in stored blood?

    <p>Gradual breakdown of RBCs</p> Signup and view all the answers

    What is the minimum percentage of original RBCs that must be supported in the recipient's circulation for at least 24 hours after transfusion?

    <p>75%</p> Signup and view all the answers

    Which of the following would MOST LIKELY occur if additive solutions were not used in packed RBCs?

    <p>More plasma would be retained in the packed RBCs</p> Signup and view all the answers

    What is the primary role of additive solutions in packed RBCs?

    <p>To maintain RBC metabolism and prevent hemolysis during storage</p> Signup and view all the answers

    What is the consequence of increased plasma retention in packed RBCs?

    <p>Decreased hemolysis during storage</p> Signup and view all the answers

    What is the primary concern addressed by the use of additive solutions in packed RBCs?

    <p>Prevention of hemolysis during storage</p> Signup and view all the answers

    What is the effect of additive solutions on glucose metabolism in packed RBCs?

    <p>Increased glucose metabolism during storage</p> Signup and view all the answers

    What is the primary benefit of removing more plasma from packed RBCs when using additive solutions?

    <p>Decreased hemolysis during storage</p> Signup and view all the answers

    What is the primary purpose of maintaining viability and function of blood components during storage?

    <p>To maximize the usage of blood in component transfusion</p> Signup and view all the answers

    What is the effect of physical changes on blood components during storage?

    <p>Decreased shelf life of blood components</p> Signup and view all the answers

    What is the primary reason why blood components are considered unacceptable if not stored in a closed system?

    <p>To minimize bacterial contamination</p> Signup and view all the answers

    What is the primary concern addressed by the use of anticoagulants in blood collection?

    <p>Prevention of physical changes during storage</p> Signup and view all the answers

    What is the benefit of optimizing blood component storage conditions?

    <p>Maximized usage of blood in component transfusion</p> Signup and view all the answers

    What is the consequence of not using additive solutions in packed RBCs?

    <p>Decreased 2,3-DPG levels</p> Signup and view all the answers

    What is the primary role of anticoagulants in blood collection and storage?

    <p>To prevent coagulation and maintain blood fluidity</p> Signup and view all the answers

    What is the primary goal of blood component preparation in the context of hemotherapy?

    <p>To maximize the usage of blood in component transfusion</p> Signup and view all the answers

    What is the primary concern during blood component preparation?

    <p>Prevention of physical changes during storage</p> Signup and view all the answers

    What is the primary concern during manual recording of blood components in the Philippines?

    <p>Inaccurate recording</p> Signup and view all the answers

    What is the primary advantage of using barcodes in blood component storage?

    <p>Accurate tracking and identification</p> Signup and view all the answers

    What is the primary consequence of bacterial contamination in blood components?

    <p>Discard of the blood component</p> Signup and view all the answers

    What is the primary function of filtration in blood component manufacturing?

    <p>To ensure no cross-contamination between blood components</p> Signup and view all the answers

    What is the primary advantage of using centrifuge equipment in blood component manufacturing?

    <p>Improved separation of blood components</p> Signup and view all the answers

    What is the primary purpose of documenting critical steps in the blood manufacturing process?

    <p>To ensure compliance with CGMP regulations</p> Signup and view all the answers

    What is the primary role of storage freezers in blood component management?

    <p>To preserve blood components at optimal temperatures</p> Signup and view all the answers

    What is the primary concern addressed by the use of plated agitator machines in blood component storage?

    <p>Prevention of blood component degradation</p> Signup and view all the answers

    What is the primary function of anticoagulants in blood component preparation?

    <p>To prevent blood clotting during collection</p> Signup and view all the answers

    What is the primary benefit of implementing robust quality control measures in blood component manufacturing?

    <p>Ensured compliance with CGMP regulations</p> Signup and view all the answers

    What is the primary purpose of refrigerators in blood component storage?

    <p>To preserve blood components at optimal temperatures</p> Signup and view all the answers

    What is the primary concern addressed by the use of additive solutions in blood component preparation?

    <p>Maintenance of optimal blood component metabolism</p> Signup and view all the answers

    What is the primary role of blood bags in blood component manufacturing?

    <p>To collect and store blood components</p> Signup and view all the answers

    Which of the following additive solutions is known to contain glucose, adenine, mannitol, and saline?

    <p>AS-7</p> Signup and view all the answers

    What is the primary mechanism by which 2,3-DPG enables oxygen release from hemoglobin?

    <p>Decreases the affinity of hemoglobin for oxygen</p> Signup and view all the answers

    What is the primary consequence of decreased 2,3-DPG levels in stored red blood cells?

    <p>Impaired oxygen release</p> Signup and view all the answers

    What is the primary function of citrate in anticoagulant solutions?

    <p>Prevents coagulation by chelating calcium</p> Signup and view all the answers

    What is the primary purpose of adenine in additive solutions?

    <p>Provides a source of energy for the red cell</p> Signup and view all the answers

    What is the primary consequence of a low pH environment on red blood cells?

    <p>Increases hemolysis</p> Signup and view all the answers

    What is the primary function of additive solutions in blood component preparation?

    <p>To maintain RBC viability and function</p> Signup and view all the answers

    What is the primary concern addressed by the use of anticoagulants in blood component preparation?

    <p>Preventing coagulation of blood components</p> Signup and view all the answers

    What is the primary benefit of separating blood components from whole blood?

    <p>Maximizing the usage of blood components</p> Signup and view all the answers

    What is the primary goal of blood component preparation in the context of hemotherapy?

    <p>To maximize the usage of blood components</p> Signup and view all the answers

    What is the primary advantage of component transfusion over whole blood transfusion?

    <p>Component transfusion is safer</p> Signup and view all the answers

    What happens to the amount of plasma retained in packed red cells when additive solutions are used?

    <p>More plasma is retained</p> Signup and view all the answers

    What is the primary concern in blood component preparation that can be addressed by the use of additive solutions?

    <p>Minimizing physical changes during storage</p> Signup and view all the answers

    What is the primary benefit of using additive solutions in packed RBC storage?

    <p>Minimizing storage hemolysis</p> Signup and view all the answers

    What is the role of additive solutions in maintaining RBC metabolism during storage?

    <p>Sustaining glucose metabolism and energy production</p> Signup and view all the answers

    How do additive solutions affect ADP production during RBC storage?

    <p>Enhance ADP production</p> Signup and view all the answers

    What is the consequence of decreased 2,3-DPG levels in stored red blood cells?

    <p>Increased oxygen affinity</p> Signup and view all the answers

    What is the primary concern in blood component preparation that can be addressed by optimizing storage conditions?

    <p>Hemolysis and RBC degradation</p> Signup and view all the answers

    What is the primary function of anticoagulants in blood collection and storage?

    <p>To prevent clotting process and maintain blood in fluid state</p> Signup and view all the answers

    What happens when a blood component is transferred from one blood bag to another?

    <p>The blood component is considered an open system</p> Signup and view all the answers

    What is the primary concern when a blood component is exposed to air?

    <p>Bacterial contamination</p> Signup and view all the answers

    What is the purpose of using barcode systems in blood banks of other countries?

    <p>To automate blood component recording</p> Signup and view all the answers

    What happens to blood components that are contaminated with bacteria?

    <p>They are discarded</p> Signup and view all the answers

    Why are additive solutions used in blood storage?

    <p>To extend the storage time of blood components</p> Signup and view all the answers

    What is the primary consequence of decreased ATP levels in stored red blood cells during storage?

    <p>Impaired RBC deformability</p> Signup and view all the answers

    What is the primary role of adenine in additive solutions during RBC storage?

    <p>To support ATP production</p> Signup and view all the answers

    What is the primary biochemical change that occurs in stored blood, leading to a decrease in pH?

    <p>Lactic acid accumulation</p> Signup and view all the answers

    What is the primary consequence of decreased 2,3-DPG levels in stored red blood cells?

    <p>Decreased oxygen release</p> Signup and view all the answers

    What is the primary role of additive solutions in packed RBCs during storage?

    <p>To prevent hemolysis</p> Signup and view all the answers

    What is the primary mechanism by which ATP is utilized in red blood cells during storage?

    <p>For various cellular functions</p> Signup and view all the answers

    What is the primary purpose of filtration in blood component manufacturing?

    <p>To ensure no contamination from one component to another</p> Signup and view all the answers

    Why is it essential to follow Current Good Manufacturing Practices (CGMP) in blood manufacturing?

    <p>To ensure the safety and purity of blood products</p> Signup and view all the answers

    What is the primary role of plated agitator machines in blood component storage?

    <p>To mix blood components with additive solutions</p> Signup and view all the answers

    What is the primary purpose of documentation in blood manufacturing?

    <p>To record the critical steps in the blood manufacturing process</p> Signup and view all the answers

    What is the primary role of storage freezers in blood component management?

    <p>To store blood components at low temperatures</p> Signup and view all the answers

    What is the primary benefit of implementing robust quality control measures in blood component manufacturing?

    <p>To ensure the safety, purity, and potency of blood products</p> Signup and view all the answers

    What is the primary consequence of decreased 2,3-DPG levels in stored red blood cells?

    <p>Decreased pH levels</p> Signup and view all the answers

    What is the primary function of anticoagulants in blood component preparation?

    <p>To prevent clotting in stored blood components</p> Signup and view all the answers

    What is the primary purpose of additive solutions in blood storage?

    <p>To maintain the quality and functionality of red blood cells</p> Signup and view all the answers

    What is the primary function of centrifuge equipment in blood component manufacturing?

    <p>To separate blood components from whole blood</p> Signup and view all the answers

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