Podcast
Questions and Answers
Opioid agonists-antagonists primarily interact with which receptor to produce analgesic and calming effects?
Opioid agonists-antagonists primarily interact with which receptor to produce analgesic and calming effects?
- Delta receptor
- Sigma receptor
- Mu receptor
- Kappa receptor (correct)
Which of the following is a common adverse effect associated with opioid agonists-antagonists?
Which of the following is a common adverse effect associated with opioid agonists-antagonists?
- Increased respiratory rate
- Euphoria
- Increased mental clarity
- Urinary retention (correct)
What class of medication may cause drug-drug interactions with opioid agonist-antagonists?
What class of medication may cause drug-drug interactions with opioid agonist-antagonists?
- Barbiturate general anesthetics (correct)
- Antifungals
- Macrolide antibiotics
- Antihistamines
For which patient population should opioid agonists-antagonists be used with caution?
For which patient population should opioid agonists-antagonists be used with caution?
Which of the following is a reason to prescribe an opioid agonist-antagonist?
Which of the following is a reason to prescribe an opioid agonist-antagonist?
What is a primary concern when administering opioid agonists-antagonists to patients?
What is a primary concern when administering opioid agonists-antagonists to patients?
Which of the following describes the mechanism of action of opioid agonist-antagonists?
Which of the following describes the mechanism of action of opioid agonist-antagonists?
Which of the following is an example of an opioid agonist-antagonist?
Which of the following is an example of an opioid agonist-antagonist?
A patient with which pre-existing condition should be monitored closely while taking opioid agonists-antagonists?
A patient with which pre-existing condition should be monitored closely while taking opioid agonists-antagonists?
Besides analgesia, what other symptom might an opioid agonist-antagonist help alleviate?
Besides analgesia, what other symptom might an opioid agonist-antagonist help alleviate?
Flashcards
Opioid Agonists–Antagonists: Mechanism of Action
Opioid Agonists–Antagonists: Mechanism of Action
High affinity for kappa receptor, low affinity for µ receptor.
Opioid Agonists-Antagonists: Names
Opioid Agonists-Antagonists: Names
Buprenorphine, butorphanol, nalbuphine, nalorphine.
Opioid Agonists–Antagonists: Why Prescribe?
Opioid Agonists–Antagonists: Why Prescribe?
Analgesic and calming effects from kappa receptor without respiratory depression from µ receptor.
Opioid Agonists-Antagonists: Indications
Opioid Agonists-Antagonists: Indications
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Opioid Agonists-Antagonists: Adverse Effects
Opioid Agonists-Antagonists: Adverse Effects
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Opioid Agonists-Antagonists: Cautions
Opioid Agonists-Antagonists: Cautions
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Opioid Agonists-Antagonists: Drug–Drug
Opioid Agonists-Antagonists: Drug–Drug
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Study Notes
- This drug class has a high affinity for the kappa receptor but a low affinity for the µ receptor.
- Includes buprenorphine, butorphanol, nalbuphine, and nalorphine.
- These are prescribed because analgesic and calming effects are created from the kappa receptor without the respiratory depression from the µ receptor.
- Indicated for treatment of moderate to severe pain, especially in those with respiratory dysfunction.
- Use with caution in patients with pre-existing physical dependence on opioids, COPD and other respiratory dysfunction, acute MI, documented CAD, or hypertension, renal or hepatic dysfunction, pregnancy and lactation.
- Adverse effects include respiratory depression, nausea, vomiting, constipation, biliary spasm, light-headedness, headache, dizziness, psychoses, anxiety, fear, hallucinations, impaired mental processes, and urinary retention.
- Drug-drug interactions can occur with barbiturate general anesthetics.
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