Mitotic Abnormalities Overview

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Questions and Answers

Which type of mitotic abnormality occurs specifically during prophase?

  • Bridge in Anaphase
  • Sticky Metaphase
  • Lagging chromosomes
  • Despiralization (correct)

What phenomenon occurs during metaphase that can cause chromosomes to not align properly?

  • C-Metaphase (correct)
  • Un-oriented chromosomes
  • Sticky Metaphase (correct)
  • Micronuclei formation

Which of the following abnormalities is categorized under anaphase?

  • Despiralization
  • Micronuclei
  • Multipolar Anaphase (correct)
  • Multinuclei

Which abnormality is characterized by chromosomes that do not separate properly and can lead to extra nuclei?

<p>Multinuclei (B)</p> Signup and view all the answers

What is a common environmental factor that contributes to the development of mitotic abnormalities?

<p>Radiation (B)</p> Signup and view all the answers

Flashcards

Mitotic Abnormalities

Errors in cell division (mitosis) caused by factors like radiation, chemicals, or pesticides.

C-Metaphase

A mitotic abnormality where chromosomes are not properly aligned at the metaphase plate. The 'C' stands for 'condensed'.

Sticky Metaphase

Chromosomes stick together during metaphase, preventing them from separating properly. This results in uneven distribution of chromosomes.

Lagging Chromosomes

Chromosomes fail to move to the poles during anaphase, getting left behind.

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Micronuclei

Small, extra nuclei formed during telophase due to chromosome fragments left behind.

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Study Notes

Mitotic Abnormalities

  • Mitotic abnormalities arise from environmental factors like radiation, chemicals, pesticides, or toxic agents.
  • The abnormalities manifest at different phases of mitosis.

Types of Mitotic Abnormalities

Prophase

  • Despiralization: Chromosomes fail to condense properly.

Metaphase

  • C-Metaphase: Chromosomes fail to align at the metaphase plate.
  • Sticky Metaphase: Chromosomes stick together.

Anaphase

  • Lagging chromosomes: Chromosomes fail to separate.
  • Sticky Anaphase: Chromosomes stick together during separation.
  • Bridge in Anaphase: Chromosomes fail to separate completely and leave a "bridge" of DNA.
  • Multipolar Anaphase: Multiple poles of spindle fibers form, pulling chromatids to multiple locations instead of two poles.

Telophase

  • Un-oriented chromosome: Chromosomes do not move towards the poles and are unaligned.
  • Multinuclei: Multiple nuclei form in a cell due to improper cytokinesis.
  • Micronuclei: Small extra nuclei form within the cell.

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