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Mitotic Inhibitors in Cell Division

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Questions and Answers

Which of the following is NOT an agent in the FOLFIRINOX regimen?

Gemcitabine (correct)
FOLinic acid
OXaliplatin
IRINotecan

What is the role of OXaliplatin in the FOLFIRINOX regimen?

Detoxifying agent
Topoisomerase inhibitor
DNA-adduct forming agent (correct)
None of the above

Why is FOLFIRINOX considered extremely toxic?

The DNA-adduct forming property of OXaliplatin (correct)
Due to the presence of IRINotecan
It contains leucovorin (folinic acid)
Its association with gemcitabine

In which type of cancer is FOLFIRINOX typically administered?

Pancreatic cancer (B) Signup and view all the answers

What is the mechanism of action of IRINotecan in the FOLFIRINOX regimen?

Topoisomerase inhibitor (B) Signup and view all the answers

Which publication introduced FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer?

New England Journal of Medicine (D) Signup and view all the answers

What factor limits the administration of FOLFIRINOX to patients?

"Unfit" status of patients (A) Signup and view all the answers

Which agent in the FOLFIRINOX regimen is used as a detoxifying agent?

FOLinic acid (C) Signup and view all the answers

'FOLFIRINOX' contains leucovorin. What is another name for leucovorin?

FOLinic acid (D) Signup and view all the answers

'FOLFIRINOX' is a combination chemotherapy regimen used for the treatment of what type of cancer?

Pancreatic cancer (C) Signup and view all the answers