Mitotic Inhibitors in Cell Division
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Questions and Answers

Which of the following is NOT an agent in the FOLFIRINOX regimen?

  • Gemcitabine (correct)
  • FOLinic acid
  • OXaliplatin
  • IRINotecan

What is the role of OXaliplatin in the FOLFIRINOX regimen?

  • Detoxifying agent
  • Topoisomerase inhibitor
  • DNA-adduct forming agent (correct)
  • None of the above

Why is FOLFIRINOX considered extremely toxic?

  • The DNA-adduct forming property of OXaliplatin (correct)
  • Due to the presence of IRINotecan
  • It contains leucovorin (folinic acid)
  • Its association with gemcitabine

In which type of cancer is FOLFIRINOX typically administered?

<p>Pancreatic cancer (B)</p> Signup and view all the answers

What is the mechanism of action of IRINotecan in the FOLFIRINOX regimen?

<p>Topoisomerase inhibitor (B)</p> Signup and view all the answers

Which publication introduced FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer?

<p>New England Journal of Medicine (D)</p> Signup and view all the answers

What factor limits the administration of FOLFIRINOX to patients?

<p>&quot;Unfit&quot; status of patients (A)</p> Signup and view all the answers

Which agent in the FOLFIRINOX regimen is used as a detoxifying agent?

<p>FOLinic acid (C)</p> Signup and view all the answers

'FOLFIRINOX' contains leucovorin. What is another name for leucovorin?

<p>FOLinic acid (D)</p> Signup and view all the answers

'FOLFIRINOX' is a combination chemotherapy regimen used for the treatment of what type of cancer?

<p><em>Pancreatic cancer</em> (C)</p> Signup and view all the answers

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