Mitotic Inhibitors in Cell Division
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Questions and Answers

Which of the following is NOT an agent in the FOLFIRINOX regimen?

  • Gemcitabine (correct)
  • FOLinic acid
  • OXaliplatin
  • IRINotecan

    • What is the role of OXaliplatin in the FOLFIRINOX regimen?

  • Detoxifying agent
  • Topoisomerase inhibitor
  • DNA-adduct forming agent (correct)
  • None of the above

    • Why is FOLFIRINOX considered extremely toxic?

  • The DNA-adduct forming property of OXaliplatin (correct)
  • Due to the presence of IRINotecan
  • It contains leucovorin (folinic acid)
  • Its association with gemcitabine

    • In which type of cancer is FOLFIRINOX typically administered?

    <p>Pancreatic cancer</p> Signup and view all the answers

    What is the mechanism of action of IRINotecan in the FOLFIRINOX regimen?

    <p>Topoisomerase inhibitor</p> Signup and view all the answers

    Which publication introduced FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer?

    <p>New England Journal of Medicine</p> Signup and view all the answers

    What factor limits the administration of FOLFIRINOX to patients?

    <p>&quot;Unfit&quot; status of patients</p> Signup and view all the answers

    Which agent in the FOLFIRINOX regimen is used as a detoxifying agent?

    <p>FOLinic acid</p> Signup and view all the answers

    'FOLFIRINOX' contains leucovorin. What is another name for leucovorin?

    <p>FOLinic acid</p> Signup and view all the answers

    'FOLFIRINOX' is a combination chemotherapy regimen used for the treatment of what type of cancer?

    <p><em>Pancreatic cancer</em></p> Signup and view all the answers

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