10 Questions
Which of the following is NOT an agent in the FOLFIRINOX regimen?
Gemcitabine
What is the role of OXaliplatin in the FOLFIRINOX regimen?
DNA-adduct forming agent
Why is FOLFIRINOX considered extremely toxic?
The DNA-adduct forming property of OXaliplatin
In which type of cancer is FOLFIRINOX typically administered?
Pancreatic cancer
What is the mechanism of action of IRINotecan in the FOLFIRINOX regimen?
Topoisomerase inhibitor
Which publication introduced FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer?
New England Journal of Medicine
What factor limits the administration of FOLFIRINOX to patients?
"Unfit" status of patients
Which agent in the FOLFIRINOX regimen is used as a detoxifying agent?
FOLinic acid
'FOLFIRINOX' contains leucovorin. What is another name for leucovorin?
FOLinic acid
'FOLFIRINOX' is a combination chemotherapy regimen used for the treatment of what type of cancer?
Pancreatic cancer
Explore the mechanism of action of mitotic inhibitors that prevent cellular replication by physically inhibiting cytoskeletal components, particularly microtubules like docetaxel and paclitaxel. Learn how these molecules impede the formation or re-formation of critical structures during mitosis.
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