Microbiology Quiz: Antibiotics and Bacteria

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Questions and Answers

Which mechanism does chloramphenicol act on?

  • Cell wall
  • Protein synthesis sites (correct)
  • Metabolic pathways inhibition
  • DNA synthesis inhibition

Campylobacter jejuni is considered?

  • Anaerobic bacteria
  • Microaerophilic (correct)
  • Aerobic
  • Facultative

Which antibiotic does not work by binding the 50S ribosomal subunit?

  • Tedizolid
  • Erythromycin
  • Clarithromycin
  • Streptomycin (correct)

Which penicillin antibiotic must be taken by injection?

<p>Oxacillin (C)</p> Signup and view all the answers

Which of the following is not an antistaphylococcal penicillin?

<p>Piperacillin (A)</p> Signup and view all the answers

Kanamycin is produced by which bacteria?

<p>Actinomycetes (C)</p> Signup and view all the answers

The original compound isolated from Streptomyces lactamdurans is a derivative of?

<p>Actinomycetes (C)</p> Signup and view all the answers

Which of the following antibiotics is a fifth-generation cephalosporin?

<p>Ceftaroline (D)</p> Signup and view all the answers

Flashcards

Chloramphenicol's Mechanism

Chloramphenicol targets the sites where protein synthesis takes place within cells.

Campylobacter jejuni's Oxygen Needs

Campylobacter jejuni thrives in environments with low oxygen levels, but still requires some oxygen to survive.

Streptomycin's Target

Streptomycin works differently. It binds to the 30S ribosomal subunit, not the 50S subunit.

Oxacillin Administration

Oxacillin, a penicillin antibiotic, is only effective when given intravenously or intramuscularly, not orally.

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Piperacillin's Specificity

Piperacillin, unlike other antistaphylococcal penicillins, doesn't specifically target staphylococcal infections.

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Kanamycin's Source

Kanamycin, an antibiotic, originates from a group of bacteria known as Actinomycetes. These bacteria play a role in producing many useful antibiotics.

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Streptomyces lactamdurans' Origin

The original compound isolated from Streptomyces lactamdurans is a derivative of Actinomycetes, a group of bacteria known for producing various antibacterial agents.

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Ceftaroline's Generation

Ceftaroline is a powerful cephalosporin antibiotic that belongs to the fifth generation, indicating advanced properties and effectiveness in combating resistant bacteria.

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Study Notes

Cephalosporinase and Chloramphenicol Acetyltransferase

  • Cephalosporinase is a type of β-lactamase.
  • Chloramphenicol acetyltransferase is an enzyme that inactivates chloramphenicol.

Bacteria and Antimicrobials

  • Campylobacter jejune is a microphilic bacteria.
  • Chloramphenicol acts by inhibiting protein synthesis.
  • Antibiotics can inhibit bacterial growth by targeting the cell wall, DNA synthesis, or metabolic pathways.

Antibiotic Mechanisms

  • Streptomycin, Clarithromycin, and Tedizold work by binding to the 50S subunit.
  • Penicillinase-resistant penicillins include Oxacillin and Dicloxacillin.
  • Antistaphylococcal antibiotics include Oxacillin, Dicloxacillin, and Nafcillin.

Antibiotic Sources

  • Kanamycin is produced by Streptomyces bacteria.
  • Cephalosporins are derived from the fungus Cephalosporium lactamdurans.

Antibiotic Generations

  • Cephamycins are a type of antibiotic.
  • Cefepime and Ceftazidime are fifth-generation cephalosporins.
  • Ceftaroline is a fifth-generation cephalosporin.

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