Microbiology Chapter on Antibiotics
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Questions and Answers

What cellular structure do erythromycin and streptomycin specifically target in bacteria?

  • Ribosome (correct)
  • Chromosome
  • Nucleus
  • Cell wall
  • Why do antibiotics like Cipro not affect human cells?

  • Human cells have different ribosomes
  • Human cells lack the targeted enzymes completely
  • Cipro is quickly metabolized and deactivated in human cells
  • Human chromosomes have a different makeup than bacterial chromosomes (correct)
  • Which cellular structure is present in most bacteria but absent in human cells and is targeted by drugs like penicillin?

  • Mitochondria
  • Cell wall (correct)
  • Cell membrane
  • Endoplasmic reticulum
  • What was the first antibiotic to be discovered?

    <p>Penicillin (B)</p> Signup and view all the answers

    What is a primary reason that some doctors predicted the end of infectious diseases in the early 1900's?

    <p>The rapid development and effect of new antibiotics. (A)</p> Signup and view all the answers

    Which of the following statements best describes the main point of the chapter, according to the provided text?

    <p>Understanding cells is fundamental to understanding life. (B)</p> Signup and view all the answers

    What is the primary goal of antibiotic treatment?

    <p>To target and disable or kill invading bacteria, while avoiding harm to the host (A)</p> Signup and view all the answers

    Based on the text, which of the following is a characteristic of antibiotics?

    <p>They are designed to bind to specific structures found in bacteria, and not in human cells. (B)</p> Signup and view all the answers

    What is the primary difference in structure between prokaryotic and eukaryotic cells?

    <p>Eukaryotic cells possess membrane-enclosed organelles, whereas prokaryotic cells do not. (B)</p> Signup and view all the answers

    Which structure within a eukaryotic cell houses the majority of its DNA?

    <p>The nucleus (C)</p> Signup and view all the answers

    How is the DNA organized in a prokaryotic cell?

    <p>It is coiled into a nucleoid region not separated by membranes. (A)</p> Signup and view all the answers

    In the analogy comparing cells to buildings, what is analogous to the cubicles of an office building regarding eukaryotic cells?

    <p>The organelles (D)</p> Signup and view all the answers

    What is the primary function of the plasma membrane?

    <p>To separate the cell from its external surroundings and regulate the movement of substances. (B)</p> Signup and view all the answers

    What are the main components of the cell's plasma membrane?

    <p>Phospholipids (C)</p> Signup and view all the answers

    Which of the following cellular structures is NOT present in prokaryotic cells?

    <p>Nucleus (B)</p> Signup and view all the answers

    What is the function of membranes in eukaryotic cells?

    <p>To maintain unique chemical environments within organelles. (B)</p> Signup and view all the answers

    Which of the following best describes the location of chromosomes in prokaryotic cells?

    <p>In a nucleoid region (B)</p> Signup and view all the answers

    What is a key distinction between the cytoplasm of prokaryotic and eukaryotic cells according to the text?

    <p>Eukaryotic cytoplasm occupies the region between the nucleus and the plasma membrane (C)</p> Signup and view all the answers

    Which statement accurately describes the evolutionary timeline of prokaryotic and eukaryotic cells?

    <p>Prokaryotic cells evolved approximately 3.5 billion years ago, much earlier than eukaryotic cells, appearing around 2.1 billion years ago. (D)</p> Signup and view all the answers

    How does the size of prokaryotic cells generally compare to that of eukaryotic cells?

    <p>Prokaryotic cells are about one-tenth the length of a typical eukaryotic cell. (C)</p> Signup and view all the answers

    What is a defining feature of eukaryotic cells that distinguishes them from prokaryotic cells in relation to organelles?

    <p>Eukaryotic cells possess membrane-bound organelles, whereas prokaryotic cells do not. (A)</p> Signup and view all the answers

    How do prokaryotic and eukaryotic cells differ in their chromosomal structure?

    <p>Prokaryotic cells typically have a singular, circular chromosome, while eukaryotic cells have one or more linear chromosomes. (C)</p> Signup and view all the answers

    Which of the following components is found in both prokaryotic and eukaryotic cells?

    <p>Plasma membrane (D)</p> Signup and view all the answers

    According to the content, what is the role of ribosomes in both prokaryotic and eukaryotic cells?

    <p>To build proteins based on gene instructions (B)</p> Signup and view all the answers

    What is the primary function of transport vesicles after they leave the endoplasmic reticulum (ER)?

    <p>To carry substances to other parts of the cell. (C)</p> Signup and view all the answers

    Which of the following characteristics is distinct to the smooth endoplasmic reticulum (ER)?

    <p>It lacks ribosomes on its surface. (C)</p> Signup and view all the answers

    Which of these is a key function of the smooth ER in liver cells?

    <p>Detoxifying circulating drugs. (D)</p> Signup and view all the answers

    How does the smooth ER contribute to drug tolerance?

    <p>By increasing its own volume and the amount of detoxifying enzymes. (A)</p> Signup and view all the answers

    What is the main role of the Golgi apparatus in cellular function, based on the analogy in the text?

    <p>To receive, finish (add details), store and distribute proteins that are made in the ER. (B)</p> Signup and view all the answers

    How do products from the ER reach the Golgi apparatus?

    <p>Inside transport vesicles. (B)</p> Signup and view all the answers

    What is the primary function of vesicles that bind with the plasma membrane?

    <p>To transfer proteins to the membrane or secrete products outside the cell (A)</p> Signup and view all the answers

    What is the purpose of the molecular identification tags that are added to proteins in the Golgi apparatus?

    <p>To mark the proteins for and sort them into batches for different destinations. (D)</p> Signup and view all the answers

    From which organelle do lysosomes typically originate?

    <p>Golgi apparatus (A)</p> Signup and view all the answers

    What is the purpose of digestive enzymes within a lysosome?

    <p>To break down large molecules (C)</p> Signup and view all the answers

    From which ‘side’ of the Golgi apparatus do finished products depart for other locations in the cell?

    <p>The shipping or trans side. (B)</p> Signup and view all the answers

    How do lysosomes assist in nutrient acquisition for single-celled protists?

    <p>By fusing with food vacuoles and digesting their contents (B)</p> Signup and view all the answers

    Besides digestion, what other crucial function do lysosomes have with regards to cellular components?

    <p>They engulf and recycle damaged organelles (D)</p> Signup and view all the answers

    What is the significance of lysosomes in embryonic development?

    <p>They release enzymes that sculpt tissues by digesting specific structures (A)</p> Signup and view all the answers

    What are the primary consequences of lysosomal storage diseases?

    <p>Engorgement of lysosomes with indigestible substances (A)</p> Signup and view all the answers

    Which organelle is responsible for the formation of vacuoles?

    <p>ER and Golgi apparatus (D)</p> Signup and view all the answers

    What is the primary mechanism by which cholera bacteria cause harm in the human body?

    <p>By producing a toxin that alters plasma membrane proteins, leading to excessive fluid excretion. (A)</p> Signup and view all the answers

    How does the spread of cholera from person to person typically occur?

    <p>Through the ingestion of contaminated food or water. (C)</p> Signup and view all the answers

    What is the reason why the Bangladeshi population has developed resistance to cholera?

    <p>Due to genetic mutations that have spread throughout the population over many generations. (B)</p> Signup and view all the answers

    What specific biological target is altered by the cholera toxin in humans

    <p>The plasma membrane proteins of intestinal cells, which leads to excessive fluid loss. (D)</p> Signup and view all the answers

    What role does the environment play in the evolution of cholera resistance in Bangladesh?

    <p>The environment promotes selective pressure towards resistant individuals. (C)</p> Signup and view all the answers

    How does the study of cholera resistance in Bangladesh potentially benefit humans?

    <p>By revealing mechanisms for human adaptation to pathogen presence. (A)</p> Signup and view all the answers

    What impact does the alteration of membrane proteins have on affected intestinal cells?

    <p>It causes the cells to excrete excessive amounts of fluid. (A)</p> Signup and view all the answers

    What survival advantage do the observed mutations provide to some individuals in Bangladesh?

    <p>They decrease the susceptibility of the individuals' plasma membrane proteins to the cholera toxin. (C)</p> Signup and view all the answers

    Flashcards

    Antibiotics

    Drugs that disable or kill infectious bacteria.

    Penicillin

    The first antibiotic discovered in 1920, revolutionizing medicine.

    Bacterial ribosome

    A structure in bacteria vital for protein production, targeted by antibiotics.

    Erythromycin and streptomycin

    Common antibiotics that bind to bacterial ribosomes.

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    Ciprofloxacin (Cipro)

    An antibiotic targeting enzymes essential for bacterial chromosome maintenance.

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    Cell wall synthesis disruption

    Mechanism used by antibiotics like penicillin to attack bacterial cells.

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    Human versus bacterial chromosomes

    Human chromosomes differ enough that antibiotics do not harm human cells.

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    Understanding cells

    Central concept in biology to comprehend how life functions.

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    Prokaryotic Cell

    A simple, single-celled organism without membrane-bound organelles.

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    Eukaryotic Cell

    A complex cell with membrane-bound organelles, including a nucleus.

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    Nucleus

    The organelle in eukaryotic cells that houses DNA, surrounded by a double membrane.

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    Nucleoid

    The region in prokaryotic cells containing coiled DNA, not membrane-bound.

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    Organelles

    Membrane-enclosed structures within eukaryotic cells that perform specific functions.

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    Plasma Membrane

    The boundary that separates living cells from their nonliving surroundings, regulating transport.

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    Membrane Structure

    Plasma membrane composed primarily of phospholipids, influencing its function.

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    Comparison of Cells

    Prokaryotic cells are simpler than eukaryotic cells, lacking internal compartments.

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    Smooth ER

    An organelle that synthesizes lipids and detoxifies drugs, lacking ribosomes.

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    Function of Smooth ER

    Smooth ER synthesizes lipids and processes drugs, increasing tolerance with exposure.

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    Lipid Synthesis

    The creation of lipids, including steroids, primarily in smooth ER.

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    Drug Tolerance

    The body's adaptation to drugs, requiring larger doses over time due to smooth ER increase.

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    Golgi Apparatus

    An organelle that modifies, sorts, and ships chemical products received from the ER.

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    Transport Vesicles

    Membrane-bound carriers that transport proteins from ER to Golgi and beyond.

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    Protein Modification

    The process of modifying proteins as they pass through Golgi, adding tags for sorting.

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    Golgi Stack Structure

    A series of flattened membrane plates where proteins enter and exit in vesicles.

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    Cytoplasm

    The jellylike fluid inside cells where organelles are suspended.

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    Chromosomes

    Structures made of DNA that carry genetic information.

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    Ribosomes

    Cellular structures that build proteins from genetic instructions.

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    Membrane-bound Organelles

    Organelles surrounded by membranes, found only in eukaryotic cells.

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    Cell Size

    Prokaryotic cells are generally smaller and simpler than eukaryotic cells.

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    Evolution of Cells

    Prokaryotic cells evolved approximately 3.5 billion years ago, eukaryotic cells around 2.1 billion years ago.

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    Lysosome

    A membrane-enclosed sac of digestive enzymes in animal cells.

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    Function of Lysosomes

    Breaks down large molecules and digests harmful substances.

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    Lysosomal Enzymes

    Enzymes that can digest proteins, fats, and nucleic acids.

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    Food Vacuoles

    Tiny sacs that engulf nutrients in some protists.

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    Lysosomal Storage Diseases

    Hereditary disorders due to missing lysosomal enzymes.

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    Tay-Sachs Disease

    A lysosomal storage disease lacking a lipid-digesting enzyme.

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    Vacuoles

    Large membrane-bound sacs in cells with various functions.

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    Role in Embryonic Development

    Lysosomes help shape structures by digesting unnecessary tissue.

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    Natural Selection

    The process where individuals better suited to the environment survive and reproduce more.

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    Genetic Variations

    Differences in genes among individuals, influencing survival and reproductive success.

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    Bacterial Resistance

    The ability of a population to withstand infections by harmful bacteria.

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    Cholera

    An infectious disease caused by cholera bacteria, leading to severe diarrhea and dehydration.

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    Mutation

    A change in a gene that can provide an advantage for survival in a population.

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    Plasma Membrane Proteins

    Proteins located in the plasma membrane that can be targeted by cholera toxins.

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    Environmental Adaptation

    The process organisms undergo to adjust to their environment for better survival.

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    Evolutionary Study

    Research that examines changes in species over time to understand survival adaptations.

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    Study Notes

    The Microscopic World of Cells

    • Cells are miniature marvels, sophisticated even at microscopic size
    • Organisms can be single-celled (prokaryotes, protists) or multicellular (plants, animals, fungi)
    • Cells of the body are specialized for different functions
    • Cells constantly interact and work together efficiently

    Antibiotics: Drugs That Target Bacterial Cells

    • Antibiotics disable or kill bacteria.
    • Penicillin was the first antibiotic, discovered in 1920.
    • Antibiotics dramatically reduced fatality rates from bacterial diseases (pneumonia, surgical infections) saving millions of lives.
    • The goal of antibiotics is to kill bacteria without harming human cells.
    • Antibiotics specifically target structures found only in bacterial cells (e.g., bacterial ribosomes, bacterial chromosome structures, bacterial cell walls).

    Comparing Prokaryotic and Eukaryotic Cells

    • Prokaryotic cells are smaller and simpler, found in Bacteria and Archaea.
    • Eukaryotic cells are larger and more complex, found in protists, plants, fungi and animals.
    • Prokaryotic cells lack membrane-bound organelles, while eukaryotic cells have organelles.
    • Both cell types have ribosomes which differ slightly in structural features.

    The Plasma Membrane

    • The plasma membrane separates the cell from its surroundings.
    • The structure of phospholipids is suitable for creating membranes
    • Phospholipid bilayers consist of hydrophilic heads and hydrophobic tails.
    • The membrane has proteins embedded in the bilayer.
    • Membranes are fluid mosaics; molecules (phospholipids and proteins) can move around.

    What Makes a Superbug?

    • Superbugs (like MRSA) are bacteria resistant to many antibiotics.
    • Some superbugs use proteins (PSMs) to damage human immune cells.
    • MRSA infections are often found in hospitals, gyms, schools

    Cell Surfaces

    • Plant cells have a rigid cell wall made of cellulose
    • Plant cells are connected by channels in the cell wall
    • Animal cells lack a rigid cell wall
    • Animal cells have an extracellular matrix and cell junctions.

    The Nucleus and Ribosomes: Genetic Control of the Cell

    • The nucleus is the control center of the cell
    • Genes (stretches of DNA) store information for protein production
    • Proteins are the workers in the cells. The perform most cellular functions.
    • Chromatin is DNA wrapped around proteins.
    • Chromosomes are long strands of DNA.
    • Cells use the information in DNA to build proteins.
    • Ribosomes synthesize proteins.

    Ribosomes

    • Ribosomes are responsible for protein synthesis.
    • Ribosomes can be free-floating in the cytosol or attached to the endoplasmic reticulum.
    • Ribosomes' components are made in the nucleus and exported to the cytoplasm for function

    The Endomembrane System:

    • Organelles (ER, Golgi apparatus, lysosomes, vacuoles) are part of the Endomembrane system
    • The endoplasmic reticulum is a main manufacturing facility in the cell. It creates a variety of molecules, including membranes.
    • Rough ER has ribosomes and makes proteins.
    • Smooth ER makes lipids
    • The Golgi Apparatus packages and modifies proteins.
    • Vesicles transport materials between parts of the endomembrane system.

    Lysosomes

    • Lysosomes break down large molecules or organelles inside the cell.
    • Lysosomes contain digestive enzymes
    • They are used during embryonic development and in cell recycling.
    • Defects in lysosomal enzymes cause lysosomal storage diseases which are often fatal.

    Vacuoles

    • Vacuoles are sacs made of membrane that bud off from the ER or Golgi apparatus.
    • Contractile vacuoles pump out excess water
    • Central vacuoles are large in plant cells and aid in plant growth, storage and protection

    Chloroplasts and Mitochondria

    • Chloroplasts perform photosynthesis; converting light energy to chemical energy (sugars).
    • Mitochondria perform cellular respiration (generating energy from sugars; converting food energy to ATP - chemical energy).
    • Both organelles contain their own DNA and ribosomes.
    • Mitochondria and chloroplasts evolved from free-living bacteria.

    The Cytoskeleton

    • The cytoskeleton is a network of protein fibers that provides structural support and movement in the cell
    • Microtubules are a type of protein fiber in the cytoskeleton
    • Intermediate filaments and microfilaments and types of protein fibers in the cytoskeleton
    • The cytoskeleton helps keep cells from collapsing, allows specific molecules to move within cells.

    Cilia and Flagella

    • Cilia or flagella are extensions from eukaryotic cells that help with movement
    • Cilia are short, numerous, and appear in a coordinated beating motion
    • Flagella are long, and function in an undulating, whip-like motion
    • Cilia and flagella share a similar internal microtubule structure

    The Evolution of Bacterial Resistance in Humans

    • Natural selection favors bacteria with advantageous mutations (resistance).
    • Repeated exposure to antibiotics can lead to resistance in bacterial populations.
    • Variations in genes related to the plasma membrane proteins may confer resistance to cholera.

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    Description

    Test your understanding of antibiotics and their effects on bacterial cells versus human cells in this microbiology quiz. Explore key concepts such as cellular structures targeted by different antibiotics, the history of antibiotic discovery, and the differences between prokaryotic and eukaryotic cells. Perfect for students studying microbiology or pharmacology.

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