Microbiology of Tuberculosis
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Questions and Answers

What is the shape of the Mycobacterium tuberculosis bacteria?

  • Straight rod
  • Spiral
  • Curved rod (correct)
  • Spherical

Which type of staining is NOT effective on Mycobacterium tuberculosis?

  • Acid-fast stains
  • Gram staining (correct)
  • Simple stains
  • Fluorescent stains

What is the primary method of transmission for tuberculosis?

  • Contact with contaminated surfaces
  • Inhalation of aerosol droplets (correct)
  • Vector-borne transmission
  • Ingestion of contaminated food

What type of tuberculosis occurs in about 5–10% of primary TB cases?

<p>Reactivation tuberculosis (D)</p> Signup and view all the answers

What structure forms within an infected area during tuberculosis infection?

<p>Granuloma (D)</p> Signup and view all the answers

Which media is used to culture Mycobacterium tuberculosis?

<p>Lowenstein–Jensen media (A)</p> Signup and view all the answers

What cellular feature is characteristic of the immune response to Mycobacterium tuberculosis?

<p>Macrophage fusion (D)</p> Signup and view all the answers

Which of the following best describes how Mycobacterium tuberculosis survives in hostile environments?

<p>It is resistant to weak disinfectants (C)</p> Signup and view all the answers

What occurs during the fibrosis and calcification phase of a Ghon complex?

<p>Primary infection resolution (B)</p> Signup and view all the answers

Which of the following groups is at higher risk of contracting active TB infection?

<p>Recent immigrants from high-prevalence countries (A)</p> Signup and view all the answers

What is the most common presentation of primary tuberculosis?

<p>Usually asymptomatic (A)</p> Signup and view all the answers

Which complication is linked to extrapulmonary tuberculosis?

<p>Bronchopneumonia (B)</p> Signup and view all the answers

What symptom is commonly associated with reactivation tuberculosis?

<p>Constitutional symptoms like night sweats (A)</p> Signup and view all the answers

What is a potential renal complication of extrapulmonary tuberculosis?

<p>Sterile pyuria (B)</p> Signup and view all the answers

In which organ can miliary tuberculosis potentially manifest?

<p>Any organ in the body (B)</p> Signup and view all the answers

Which of the following symptoms is least likely to be associated with primary tuberculosis?

<p>Cough producing purulent sputum (D)</p> Signup and view all the answers

Which symptom would be suggestive of advanced tuberculosis?

<p>Fatigue and appetite loss (C)</p> Signup and view all the answers

What condition can result from tuberculosis affecting the lumbar vertebrae?

<p>Pott disease (C)</p> Signup and view all the answers

What happens to Mycobacteria when they are phagocytized by macrophages?

<p>They inhibit lysosomes and can remain dormant. (B)</p> Signup and view all the answers

Which of the following is a symptom specifically linked to pleural effusion caused by tuberculosis?

<p>Crepitations during lung auscultation (C)</p> Signup and view all the answers

Which condition is NOT a risk factor for developing tuberculosis?

<p>Healthy immune system (D)</p> Signup and view all the answers

In individuals with a compromised immune system, what can result from Mycobacteria infection?

<p>Increased areas of caseous necrosis. (B)</p> Signup and view all the answers

What characterizes latent tuberculosis in immunocompetent individuals?

<p>Dormant but viable bacteria without complications. (D)</p> Signup and view all the answers

Which of the following is a consequence of untreated tuberculosis in immunocompromised individuals?

<p>Cavity formation within the lungs. (D)</p> Signup and view all the answers

What is the primary role of macrophages in tuberculosis infection?

<p>To phagocytize Mycobacteria. (A)</p> Signup and view all the answers

Which factor could lead to a higher risk of tuberculosis reactivation?

<p>Chronic malnutrition. (C)</p> Signup and view all the answers

How does the immune system typically respond to Mycobacteria infections?

<p>By creating granulomas to wall off the infection. (D)</p> Signup and view all the answers

What can be a consequence of caseous necrosis in tuberculosis?

<p>Cavity formation in the lungs. (A)</p> Signup and view all the answers

Which of the following statements about tuberculosis is true?

<p>Latent tuberculosis does not lead to progression in healthy individuals. (A)</p> Signup and view all the answers

What does a positive PPD result indicate?

<p>Evidence of exposure to TB (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of interferon gamma release assays (IGRAs)?

<p>Provides immediate results in field settings (D)</p> Signup and view all the answers

What is the first line treatment for active TB?

<p>Isoniazid, rifampin, pyrazinamide, ethambutol (C)</p> Signup and view all the answers

What could lead to a false-positive PPD test result?

<p>Immunization with BCG vaccine (D)</p> Signup and view all the answers

Which medication is typically used for prophylactic treatment against tuberculosis?

<p>BCG vaccine (C)</p> Signup and view all the answers

What is a common reason for a false-negative PPD test result?

<p>Sarcoidosis or malnutrition (B)</p> Signup and view all the answers

What is indicated by an induration area of ≥ 5mm in a PPD skin test for immunocompromised individuals?

<p>Positive result for TB (B)</p> Signup and view all the answers

Which of the following is a hallmark of active TB as seen on a chest X-ray?

<p>Cavities (A)</p> Signup and view all the answers

What characterizes extensively drug-resistant TB?

<p>Resistant to isoniazid, rifampin, and any fluoroquinolone (B)</p> Signup and view all the answers

Which symptom is NOT typically associated with systemic infection due to TB?

<p>Bradycardia (D)</p> Signup and view all the answers

What is the significance of the Ranke complex in the context of TB?

<p>Sign of healed primary TB (A)</p> Signup and view all the answers

Which of the following is a condition that could be indicated by tubercles in the eye?

<p>Choroidal infection (D)</p> Signup and view all the answers

What does a PPD induration area of ≥ 10mm imply for individuals from high-prevalence countries?

<p>Positive for TB infection (D)</p> Signup and view all the answers

Which of the following best describes a sign of systemic TB infection?

<p>Weight loss (A)</p> Signup and view all the answers

Which group would have a positive PPD result with an induration area of ≥ 15mm?

<p>Individuals with no known risk for TB (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic feature of a systemic infection in TB?

<p>Persistent cough (A)</p> Signup and view all the answers

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