Microbiology: Mechanisms of Loss of Function
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Questions and Answers

Which mechanism involves the insertion, deletion, and rearrangement of DNA?

  • Homologous recombination
  • Loss of function drivers
  • Point mutation
  • Illegitimate recombination (correct)

What is a common driver of loss of function according to the text?

  • Absence of purifying selection for gene function (correct)
  • Adaptive gain of function
  • Maximizing metabolic burden
  • Increased gene expression

According to Hughes and Andersson (2015), what is a key consideration in the cost/benefit analysis of reduced genome content?

  • Maximizing metabolic burden
  • Enhancing genetic diversity
  • Minimizing adaptive potential
  • Balancing deletions to insertions (correct)

Why might strategies to minimize gene loss in the absence of selection be beneficial for bacterial survival?

<p>To maximize adaptive potential (D)</p> Signup and view all the answers

Which process leads to improved fitness by favoring the loss of function?

<p>Adaptive loss (D)</p> Signup and view all the answers

What is a common feature of lysogenic conversion in bacterial pathogens?

<p>Expression of a new phenotype in the bacterial host (A)</p> Signup and view all the answers

Which of the following bacteria encode the Cholera toxin as part of lysogenic conversion?

<p>Vibrio cholerae (A)</p> Signup and view all the answers

In generalized transduction, what does the packaging start from in phages?

<p>Ends or pac sites (B)</p> Signup and view all the answers

How is the process of packaging DNA in phages during generalized transduction analogized in the text?

<p>Packing groceries at the store (B)</p> Signup and view all the answers

What is a key feature that differentiates pathogenicity islands (PAIs) from other genomic islands?

<p>Specific association with virulence factors (B)</p> Signup and view all the answers

What is an essential role of transposons in bacterial genomes?

<p>Facilitating horizontal gene transfer (D)</p> Signup and view all the answers

What type of mutations can cause a gene to lose function and become a pseudogene?

<p>Nonsense and frameshift mutations (A)</p> Signup and view all the answers

How can missense mutations contribute to the formation of pseudogenes?

<p>By altering the amino acid sequence (A)</p> Signup and view all the answers

In the context of new lifestyle adaptation, what role can pseudogenes play according to new thinking?

<p>Serving as an adaptive repertoire of selectable traits (C)</p> Signup and view all the answers

What is the main reason pseudogenes are not always eliminated despite selective pressure?

<p>Some pseudogenes are transcribed and translated into active proteins (D)</p> Signup and view all the answers

Which of the following statements best describes pathoadaptation in the evolution of pseudogenes?

<p>Mutations in pseudogenes confer a strong selective advantage in virulent niches (B)</p> Signup and view all the answers

Based on new thinking, what potential role do pseudogenes play in pathogenic evolution?

<p>Serving as a source of selectable traits for improving pathogen fitness (B)</p> Signup and view all the answers

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