Microbial Chemotherapy: Selective Toxicity and Antimicrobial Agents
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Questions and Answers

Who first proposed the concept of chemotherapy?

  • Paul Ehrlich (correct)
  • Robert Koch
  • Alexander Fleming
  • Louis Pasteur

What is the goal of antimicrobial therapy?

  • To destroy infective agents without harming host cells (correct)
  • To boost the immune response
  • To harm the host cells
  • To stimulate pathogen growth

What are examples of the first chemotherapeutic drugs against infectious agents?

  • Steroids and painkillers
  • Insulin and penicillin
  • Vaccines and antivirals
  • Sulphanilamide and antibiotics (correct)

What did Paul Ehrlich emphasize with his concept of chemotherapy?

<p>Selective toxicity (A)</p> Signup and view all the answers

Why do public health strategies for vaccines require different funding and organisation compared to chemotherapy products?

<p>Vaccines often provide lifelong protection with only one application (D)</p> Signup and view all the answers

What is the key characteristic of an ideal antimicrobial drug according to the text?

<p>Complementing and assisting the host defenses (A)</p> Signup and view all the answers

Which approach refers to the use of antimicrobial drugs for preventing infection in susceptible people?

<p>Prophylaxis (B)</p> Signup and view all the answers

What is typically a characteristic of the origins of antimicrobial drugs as mentioned in the text?

<p>Mostly natural products of micro joined with various preselected functional groups (D)</p> Signup and view all the answers

In the context of antimicrobial drugs, what sets up a 3-way conflict in the body according to the text?

<p>The host defense systems, chemical drugs, and infectious agents (B)</p> Signup and view all the answers

What is one of the key questions regarding antibacterial agents as mentioned in the text?

<p>The route of administration and when it is used (A)</p> Signup and view all the answers

What is the concept of selective toxicity in antimicrobial therapy?

<p>The drug should only target pathogenic cells without harming host cells (A)</p> Signup and view all the answers

Why do pharmaceutical companies see profitability in chemotherapeutic products?

<p>They need multiple applications for effectiveness (A)</p> Signup and view all the answers

Who first proposed the concept of chemotherapy?

<p>Paul Ehrlich (D)</p> Signup and view all the answers

What is the goal of antimicrobial therapy?

<p>To administer drugs that destroy infective agents without harming the host cells (C)</p> Signup and view all the answers

What sets up a 3-way conflict in the body in the context of antimicrobial drugs?

<p>The struggle between pathogenic cells, host cells, and antimicrobial drugs (A)</p> Signup and view all the answers

What is the primary characteristic of an ideal antimicrobial drug according to the text?

<p>Has a long plasma half-life for once-a-day dosing (B)</p> Signup and view all the answers

Which type of antimicrobial drug is referred to as antibiotics?

<p>Natural products of micro with preselected functional groups (C)</p> Signup and view all the answers

What is the goal of combined therapy in the context of antimicrobial drugs?

<p>To prevent emergence of resistant species (D)</p> Signup and view all the answers

What does an ideal antimicrobial drug NOT cause?

<p>Antimicrobial resistance (A)</p> Signup and view all the answers

What type of drugs are referred to as antifungals, antiprotozoans, and antivirals?

<p>Agents against fungi, parasite, and virus (B)</p> Signup and view all the answers

What is the primary characteristic of the origins of antimicrobial drugs as mentioned in the text?

<p>Nature-metabolic products of fermentation pathways of bacteria and fungi (D)</p> Signup and view all the answers

What does inappropriate use of combined therapy lead to?

<p>Emergence of resistant species (A)</p> Signup and view all the answers

What is the key question regarding antibacterial agents as mentioned in the text?

<p>Where does it go (B)</p> Signup and view all the answers

What is the primary characteristic of the interaction between drug, host, and microbe in the body?

<p>The chemical tips the balance in favor of the innate and acquired immune systems. (A)</p> Signup and view all the answers

What characteristic decreases selective toxicity and increases side effects?

<p>Acting upon a structure common to both microorganism and host cell (C)</p> Signup and view all the answers

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