25 Questions
Who first proposed the concept of chemotherapy?
Paul Ehrlich
What is the goal of antimicrobial therapy?
To destroy infective agents without harming host cells
What are examples of the first chemotherapeutic drugs against infectious agents?
Sulphanilamide and antibiotics
What did Paul Ehrlich emphasize with his concept of chemotherapy?
Selective toxicity
Why do public health strategies for vaccines require different funding and organisation compared to chemotherapy products?
Vaccines often provide lifelong protection with only one application
What is the key characteristic of an ideal antimicrobial drug according to the text?
Complementing and assisting the host defenses
Which approach refers to the use of antimicrobial drugs for preventing infection in susceptible people?
Prophylaxis
What is typically a characteristic of the origins of antimicrobial drugs as mentioned in the text?
Mostly natural products of micro joined with various preselected functional groups
In the context of antimicrobial drugs, what sets up a 3-way conflict in the body according to the text?
The host defense systems, chemical drugs, and infectious agents
What is one of the key questions regarding antibacterial agents as mentioned in the text?
The route of administration and when it is used
What is the concept of selective toxicity in antimicrobial therapy?
The drug should only target pathogenic cells without harming host cells
Why do pharmaceutical companies see profitability in chemotherapeutic products?
They need multiple applications for effectiveness
Who first proposed the concept of chemotherapy?
Paul Ehrlich
What is the goal of antimicrobial therapy?
To administer drugs that destroy infective agents without harming the host cells
What sets up a 3-way conflict in the body in the context of antimicrobial drugs?
The struggle between pathogenic cells, host cells, and antimicrobial drugs
What is the primary characteristic of an ideal antimicrobial drug according to the text?
Has a long plasma half-life for once-a-day dosing
Which type of antimicrobial drug is referred to as antibiotics?
Natural products of micro with preselected functional groups
What is the goal of combined therapy in the context of antimicrobial drugs?
To prevent emergence of resistant species
What does an ideal antimicrobial drug NOT cause?
Antimicrobial resistance
What type of drugs are referred to as antifungals, antiprotozoans, and antivirals?
Agents against fungi, parasite, and virus
What is the primary characteristic of the origins of antimicrobial drugs as mentioned in the text?
Nature-metabolic products of fermentation pathways of bacteria and fungi
What does inappropriate use of combined therapy lead to?
Emergence of resistant species
What is the key question regarding antibacterial agents as mentioned in the text?
Where does it go
What is the primary characteristic of the interaction between drug, host, and microbe in the body?
The chemical tips the balance in favor of the innate and acquired immune systems.
What characteristic decreases selective toxicity and increases side effects?
Acting upon a structure common to both microorganism and host cell
This quiz covers the concept of microbial chemotherapy, focusing on selective toxicity and antimicrobial products. It includes readings from 'Hugo and Russell’s Pharmaceutical Microbiology, 8th edition', 'Cowan and Talaro- Microbiology: A systems approach', and 'Mims 5th Ed'. The quiz delves into the concept first proposed by Paul Ehrlich and the requirements for an antimicrobial product to exhibit selective toxicity.
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