Microbial Chemotherapy: Selective Toxicity and Antimicrobial Agents

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Who first proposed the concept of chemotherapy?

Paul Ehrlich (correct)

Robert Koch

Alexander Fleming

Louis Pasteur

What is the goal of antimicrobial therapy?

To destroy infective agents without harming host cells (correct)

To boost the immune response

To harm the host cells

To stimulate pathogen growth

What are examples of the first chemotherapeutic drugs against infectious agents?

Steroids and painkillers

Insulin and penicillin

Vaccines and antivirals

Sulphanilamide and antibiotics (correct)

What did Paul Ehrlich emphasize with his concept of chemotherapy?

Selective toxicity Signup and view all the answers

Why do public health strategies for vaccines require different funding and organisation compared to chemotherapy products?

Vaccines often provide lifelong protection with only one application Signup and view all the answers

What is the key characteristic of an ideal antimicrobial drug according to the text?

Complementing and assisting the host defenses Signup and view all the answers

Which approach refers to the use of antimicrobial drugs for preventing infection in susceptible people?

Prophylaxis Signup and view all the answers

What is typically a characteristic of the origins of antimicrobial drugs as mentioned in the text?

Mostly natural products of micro joined with various preselected functional groups Signup and view all the answers

In the context of antimicrobial drugs, what sets up a 3-way conflict in the body according to the text?

The host defense systems, chemical drugs, and infectious agents Signup and view all the answers

What is one of the key questions regarding antibacterial agents as mentioned in the text?

The route of administration and when it is used Signup and view all the answers

What is the concept of selective toxicity in antimicrobial therapy?

The drug should only target pathogenic cells without harming host cells Signup and view all the answers

Why do pharmaceutical companies see profitability in chemotherapeutic products?

They need multiple applications for effectiveness Signup and view all the answers

Who first proposed the concept of chemotherapy?

Paul Ehrlich Signup and view all the answers

What is the goal of antimicrobial therapy?

To administer drugs that destroy infective agents without harming the host cells Signup and view all the answers

What sets up a 3-way conflict in the body in the context of antimicrobial drugs?

The struggle between pathogenic cells, host cells, and antimicrobial drugs Signup and view all the answers

What is the primary characteristic of an ideal antimicrobial drug according to the text?

Has a long plasma half-life for once-a-day dosing Signup and view all the answers

Which type of antimicrobial drug is referred to as antibiotics?

Natural products of micro with preselected functional groups Signup and view all the answers

What is the goal of combined therapy in the context of antimicrobial drugs?

To prevent emergence of resistant species Signup and view all the answers

What does an ideal antimicrobial drug NOT cause?

Antimicrobial resistance Signup and view all the answers

What type of drugs are referred to as antifungals, antiprotozoans, and antivirals?

Agents against fungi, parasite, and virus Signup and view all the answers

What is the primary characteristic of the origins of antimicrobial drugs as mentioned in the text?

Nature-metabolic products of fermentation pathways of bacteria and fungi Signup and view all the answers

What does inappropriate use of combined therapy lead to?

Emergence of resistant species Signup and view all the answers

What is the key question regarding antibacterial agents as mentioned in the text?

Where does it go Signup and view all the answers

What is the primary characteristic of the interaction between drug, host, and microbe in the body?

The chemical tips the balance in favor of the innate and acquired immune systems. Signup and view all the answers

What characteristic decreases selective toxicity and increases side effects?

Acting upon a structure common to both microorganism and host cell Signup and view all the answers

Microbial Chemotherapy: Selective Toxicity and Antimicrobial Agents

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Questions and Answers

Who first proposed the concept of chemotherapy?

What is the goal of antimicrobial therapy?

What are examples of the first chemotherapeutic drugs against infectious agents?

What did Paul Ehrlich emphasize with his concept of chemotherapy?

Why do public health strategies for vaccines require different funding and organisation compared to chemotherapy products?

What is the key characteristic of an ideal antimicrobial drug according to the text?

Which approach refers to the use of antimicrobial drugs for preventing infection in susceptible people?

What is typically a characteristic of the origins of antimicrobial drugs as mentioned in the text?

In the context of antimicrobial drugs, what sets up a 3-way conflict in the body according to the text?

What is one of the key questions regarding antibacterial agents as mentioned in the text?

What is the concept of selective toxicity in antimicrobial therapy?

Why do pharmaceutical companies see profitability in chemotherapeutic products?

Who first proposed the concept of chemotherapy?

What is the goal of antimicrobial therapy?

What sets up a 3-way conflict in the body in the context of antimicrobial drugs?

What is the primary characteristic of an ideal antimicrobial drug according to the text?

Which type of antimicrobial drug is referred to as antibiotics?

What is the goal of combined therapy in the context of antimicrobial drugs?

What does an ideal antimicrobial drug NOT cause?

What type of drugs are referred to as antifungals, antiprotozoans, and antivirals?

What is the primary characteristic of the origins of antimicrobial drugs as mentioned in the text?

What does inappropriate use of combined therapy lead to?

What is the key question regarding antibacterial agents as mentioned in the text?

What is the primary characteristic of the interaction between drug, host, and microbe in the body?

What characteristic decreases selective toxicity and increases side effects?

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