Podcast
Questions and Answers
Which cell surface proteins play a central role in presenting peptides to CD8+ T cells?
Which cell surface proteins play a central role in presenting peptides to CD8+ T cells?
- Rotes of antigen entry
- MHC class I molecules (correct)
- Dendritic cells
- MHC class II molecules
What is the main role of MHC class II molecules?
What is the main role of MHC class II molecules?
- Code for alpha and beta chains
- Activate CD4 T lymphocytes
- Present peptides to CD8+ T cells
- Present peptides from extracellular proteins to CD4+ T cells (correct)
What is the significance of the peptide-binding cleft in MHC molecules?
What is the significance of the peptide-binding cleft in MHC molecules?
- Contains polymorphic amino acids (correct)
- Influences the MHC shape and chemical properties
- Identifies specific amino acid residues
- Activates CD8+ T cells
Which type of T cells do MHC class I molecules present peptides to?
Which type of T cells do MHC class I molecules present peptides to?
What is the role of MHC molecules in antigen presentation?
What is the role of MHC molecules in antigen presentation?
What is the primary function of Class I MHC molecules?
What is the primary function of Class I MHC molecules?
Which type of T cells recognize Class II MHC molecules?
Which type of T cells recognize Class II MHC molecules?
What is the significance of MHC haplotypes in immune responses?
What is the significance of MHC haplotypes in immune responses?
Which region of MHC molecules are encoded by polymorphic genes?
Which region of MHC molecules are encoded by polymorphic genes?
What do Class II MHC molecules primarily present?
What do Class II MHC molecules primarily present?
Which class of MHC molecules presents peptides derived from intracellular proteins to CD8 T cells?
Which class of MHC molecules presents peptides derived from intracellular proteins to CD8 T cells?
In the context of MHC, which cells interact with peptides presented by MHC Class II molecules?
In the context of MHC, which cells interact with peptides presented by MHC Class II molecules?
What is the main role of MHC Class II molecules in antigen presentation?
What is the main role of MHC Class II molecules in antigen presentation?
Which gene loci were initially identified through research on tissue transplantation and encode for MHC proteins?
Which gene loci were initially identified through research on tissue transplantation and encode for MHC proteins?
What is the significance of matching MHC alleles between the donor and recipient in tissue transplantation?
What is the significance of matching MHC alleles between the donor and recipient in tissue transplantation?
Which type of cells primarily express Class II MHC molecules?
Which type of cells primarily express Class II MHC molecules?
What is the main role of Class I MHC molecules in the immune system?
What is the main role of Class I MHC molecules in the immune system?
What is the significance of matching MHC alleles in transplantation?
What is the significance of matching MHC alleles in transplantation?
What do Class II MHC molecules present peptides derived from?
What do Class II MHC molecules present peptides derived from?
Where are Class I MHC molecules expressed?
Where are Class I MHC molecules expressed?
Which type of T cells are primarily involved in cell-mediated immune responses against infected or abnormal cells?
Which type of T cells are primarily involved in cell-mediated immune responses against infected or abnormal cells?
What is the role of Class II MHC molecules in the immune response?
What is the role of Class II MHC molecules in the immune response?
Which type of proteins do Class I MHC molecules primarily present peptides from?
Which type of proteins do Class I MHC molecules primarily present peptides from?
What is the main function of dendritic cells in antigen presentation?
What is the main function of dendritic cells in antigen presentation?
What structural feature of MHC molecules allows them to present a wide range of peptides to T cell receptors?
What structural feature of MHC molecules allows them to present a wide range of peptides to T cell receptors?
What is the primary difference in the expression pattern of Class I and Class II MHC molecules?
What is the primary difference in the expression pattern of Class I and Class II MHC molecules?
Which type of T lymphocytes interact with Class I MHC molecules to present intracellular peptides?
Which type of T lymphocytes interact with Class I MHC molecules to present intracellular peptides?
What is the role of dendritic cells in the context of antigen capture and presentation?
What is the role of dendritic cells in the context of antigen capture and presentation?
What feature distinguishes the peptide binding cleft of Class I MHC molecules from that of Class II MHC molecules?
What feature distinguishes the peptide binding cleft of Class I MHC molecules from that of Class II MHC molecules?
Which statement accurately describes the cellular distribution of Class I and Class II MHC molecules?
Which statement accurately describes the cellular distribution of Class I and Class II MHC molecules?
What distinguishes the peptide binding cleft of Class I MHC molecules from Class II MHC molecules?
What distinguishes the peptide binding cleft of Class I MHC molecules from Class II MHC molecules?
How do peptides typically enter the endoplasmic reticulum (ER) for binding with Class I MHC molecules?
How do peptides typically enter the endoplasmic reticulum (ER) for binding with Class I MHC molecules?
Which cell surface proteins play a central role in presenting peptides to CD4+ T cells?
Which cell surface proteins play a central role in presenting peptides to CD4+ T cells?
What is the role of dendritic cells in antigen capture and presentation?
What is the role of dendritic cells in antigen capture and presentation?
How do MHC cell surface proteins activate CD4+ T lymphocytes?
How do MHC cell surface proteins activate CD4+ T lymphocytes?
In which cellular compartment are peptides loaded onto Class II MHC molecules?
In which cellular compartment are peptides loaded onto Class II MHC molecules?
Why is the peptide-binding cleft of MHC molecules considered highly polymorphic?
Why is the peptide-binding cleft of MHC molecules considered highly polymorphic?
What happens when peptide antigens are presented on the cell surface for recognition by T cell receptors on CD8+ cytotoxic T cells?
What happens when peptide antigens are presented on the cell surface for recognition by T cell receptors on CD8+ cytotoxic T cells?
What initiates immune responses following interaction between MHC-bound peptide antigens and T cell receptors?
What initiates immune responses following interaction between MHC-bound peptide antigens and T cell receptors?
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