Podcast
Questions and Answers
Which type of T cells can respond only to peptides displayed by class I MHC molecules?
Which type of T cells can respond only to peptides displayed by class I MHC molecules?
- CD4- T cells
- CD8+ T cells (correct)
- CD4+ T cells
- CD8- T cells
Which domains of class II MHC molecules contain the binding site for the CD4 T cell coreceptor?
Which domains of class II MHC molecules contain the binding site for the CD4 T cell coreceptor?
- α1 and β1 domains
- Transmembrane and cytoplasmic domains
- α3 and β2 domains
- α2 and β2 domains (correct)
What is the function of the α3 domain of class I MHC molecules?
What is the function of the α3 domain of class I MHC molecules?
- Contains a cleft for peptide binding
- Binds CD8 T cell coreceptor (correct)
- Binds CD4 T cell coreceptor
- Associates with β2-microglobulin
What does the polymorphism of MHC genes refer to?
What does the polymorphism of MHC genes refer to?
What makes MHC molecules the most polymorphic of all proteins in mammals?
What makes MHC molecules the most polymorphic of all proteins in mammals?
How many alleles of each MHC gene does an individual inherit and express?
How many alleles of each MHC gene does an individual inherit and express?
What is the role of MHC polymorphism in dealing with the diversity of microbes?
What is the role of MHC polymorphism in dealing with the diversity of microbes?
Why does the existence of many different MHC molecules in the population prevent everyone from succumbing to newly encountered or mutated microbes?
Why does the existence of many different MHC molecules in the population prevent everyone from succumbing to newly encountered or mutated microbes?
Study Notes
MHC Molecules and T Cells
- CD8 T cells can respond only to peptides displayed by class I MHC molecules
- The binding site for the CD4 T cell coreceptor is located in the β2 domain of class II MHC molecules
- The α3 domain of class I MHC molecules serves as a binding site for CD8
MHC Polymorphism
- MHC gene polymorphism refers to the existence of multiple alleles of each MHC gene in the population
- MHC molecules are the most polymorphic of all proteins in mammals due to the large number of alleles and their high degree of variability
- An individual inherits and expresses two alleles of each MHC gene, one from each parent
Role of MHC Polymorphism in Immunity
- MHC polymorphism allows individuals to respond to a diverse range of microbes
- The existence of many different MHC molecules in the population prevents everyone from succumbing to newly encountered or mutated microbes
- This is because a pathogen that can evade the immune system of one individual may be targeted by the MHC molecules of another individual
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Description
Test your knowledge on Major Histocompatibility Complex (MHC) molecules and T cell activation. This quiz covers the α3 domain, β2-microglobulin, CD8 T cell coreceptor, CD4, class I MHC molecules, and class II MHC molecules.
