MHC Molecules and T Cell Activation
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Questions and Answers

Which type of T cells can respond only to peptides displayed by class I MHC molecules?

  • CD4- T cells
  • CD8+ T cells (correct)
  • CD4+ T cells
  • CD8- T cells
  • Which domains of class II MHC molecules contain the binding site for the CD4 T cell coreceptor?

  • α1 and β1 domains
  • Transmembrane and cytoplasmic domains
  • α3 and β2 domains
  • α2 and β2 domains (correct)
  • What is the function of the α3 domain of class I MHC molecules?

  • Contains a cleft for peptide binding
  • Binds CD8 T cell coreceptor (correct)
  • Binds CD4 T cell coreceptor
  • Associates with β2-microglobulin
  • What does the polymorphism of MHC genes refer to?

    <p>Variability in alleles among individuals in the population</p> Signup and view all the answers

    What makes MHC molecules the most polymorphic of all proteins in mammals?

    <p>They are inherited and not generated de novo by somatic gene recombination</p> Signup and view all the answers

    How many alleles of each MHC gene does an individual inherit and express?

    <p>Two</p> Signup and view all the answers

    What is the role of MHC polymorphism in dealing with the diversity of microbes?

    <p>Ensuring some members of the population can present peptides from any microbial protein antigen</p> Signup and view all the answers

    Why does the existence of many different MHC molecules in the population prevent everyone from succumbing to newly encountered or mutated microbes?

    <p>By ensuring at least some individuals can mount effective immune responses to peptide antigens</p> Signup and view all the answers

    Study Notes

    MHC Molecules and T Cells

    • CD8 T cells can respond only to peptides displayed by class I MHC molecules
    • The binding site for the CD4 T cell coreceptor is located in the β2 domain of class II MHC molecules
    • The α3 domain of class I MHC molecules serves as a binding site for CD8

    MHC Polymorphism

    • MHC gene polymorphism refers to the existence of multiple alleles of each MHC gene in the population
    • MHC molecules are the most polymorphic of all proteins in mammals due to the large number of alleles and their high degree of variability
    • An individual inherits and expresses two alleles of each MHC gene, one from each parent

    Role of MHC Polymorphism in Immunity

    • MHC polymorphism allows individuals to respond to a diverse range of microbes
    • The existence of many different MHC molecules in the population prevents everyone from succumbing to newly encountered or mutated microbes
    • This is because a pathogen that can evade the immune system of one individual may be targeted by the MHC molecules of another individual

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    Description

    Test your knowledge on Major Histocompatibility Complex (MHC) molecules and T cell activation. This quiz covers the α3 domain, β2-microglobulin, CD8 T cell coreceptor, CD4, class I MHC molecules, and class II MHC molecules.

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