MHC Peptide-Binding Clefts Quiz
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Questions and Answers

Which of the following is true about anchor residues in MHC molecules?

  • They determine the optimal length and amino acid sequence of peptides that can bind to MHC molecules
  • They are located in the peptide-binding clefts of MHC molecules (correct)
  • They are recognized by the antigen receptors of T cells
  • They project upward and are displayed on the surface of antigen-presenting cells

    • Which of the following is true about the peptide display function of MHC molecules?

  • MHC molecules have a narrow specificity for peptide binding
  • Peptides are recognized by the antigen receptors of B cells
  • Each MHC molecule can present only one peptide at a time (correct)
  • Each MHC molecule can present many peptides at a time

    • What is the role of anchor residues in determining peptide binding to MHC molecules?

  • Anchor residues anchor the peptides in the cleft of the MHC molecule (correct)
  • Anchor residues project upward and are recognized by the antigen receptors of T cells
  • Anchor residues determine the length and amino acid sequence of peptides that can bind to MHC molecules
  • Anchor residues are located in the floors of the peptide-binding clefts of MHC molecules

    • What is the mechanism by which MHC molecules display peptides?

    <p>Conversion of proteins into peptides</p> Signup and view all the answers

    What percentage of MHC molecules on an APC need to display a peptide to initiate an immune response?

    <p>1-5%</p> Signup and view all the answers

    Why do we not develop autoimmune responses to self antigens?

    <p>T cells specific for self antigens are killed or inactivated</p> Signup and view all the answers

    During viral infections, which proteins are preferentially presented by MHC molecules?

    <p>Viral proteins</p> Signup and view all the answers

    Which of the following is true regarding the antigen display function of MHC molecules?

    <p>Peptides are the only type of antigens that can bind to MHC molecules</p> Signup and view all the answers

    Which of the following is true regarding the stability of MHC molecules on cell surfaces?

    <p>MHC molecules degrade inside cells if they do not bind to peptides</p> Signup and view all the answers

    What is the mechanism by which class I MHC molecules acquire their peptides?

    <p>From cytosolic proteins</p> Signup and view all the answers

    Why are MHC molecules able to present foreign antigens despite the presence of self antigens in an APC?

    <p>New MHC molecules are constantly being synthesized and are adept at capturing any peptides that are present in cells</p> Signup and view all the answers

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