MHC Peptide-Binding Clefts Quiz

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Which of the following is true about anchor residues in MHC molecules?

They determine the optimal length and amino acid sequence of peptides that can bind to MHC molecules

They are located in the peptide-binding clefts of MHC molecules (correct)

They are recognized by the antigen receptors of T cells

They project upward and are displayed on the surface of antigen-presenting cells

Which of the following is true about the peptide display function of MHC molecules?

MHC molecules have a narrow specificity for peptide binding

Peptides are recognized by the antigen receptors of B cells

Each MHC molecule can present only one peptide at a time (correct)

Each MHC molecule can present many peptides at a time

What is the role of anchor residues in determining peptide binding to MHC molecules?

Anchor residues anchor the peptides in the cleft of the MHC molecule (correct)

Anchor residues project upward and are recognized by the antigen receptors of T cells

Anchor residues determine the length and amino acid sequence of peptides that can bind to MHC molecules

Anchor residues are located in the floors of the peptide-binding clefts of MHC molecules

What is the mechanism by which MHC molecules display peptides?

Conversion of proteins into peptides Signup and view all the answers

What percentage of MHC molecules on an APC need to display a peptide to initiate an immune response?

1-5% Signup and view all the answers

Why do we not develop autoimmune responses to self antigens?

T cells specific for self antigens are killed or inactivated Signup and view all the answers

During viral infections, which proteins are preferentially presented by MHC molecules?

Viral proteins Signup and view all the answers

Which of the following is true regarding the antigen display function of MHC molecules?

Peptides are the only type of antigens that can bind to MHC molecules Signup and view all the answers

Which of the following is true regarding the stability of MHC molecules on cell surfaces?

MHC molecules degrade inside cells if they do not bind to peptides Signup and view all the answers

What is the mechanism by which class I MHC molecules acquire their peptides?

From cytosolic proteins Signup and view all the answers

Why are MHC molecules able to present foreign antigens despite the presence of self antigens in an APC?

New MHC molecules are constantly being synthesized and are adept at capturing any peptides that are present in cells Signup and view all the answers

MHC Peptide-Binding Clefts Quiz

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Questions and Answers

Which of the following is true about anchor residues in MHC molecules?

Which of the following is true about the peptide display function of MHC molecules?

What is the role of anchor residues in determining peptide binding to MHC molecules?

What is the mechanism by which MHC molecules display peptides?

What percentage of MHC molecules on an APC need to display a peptide to initiate an immune response?

Why do we not develop autoimmune responses to self antigens?

During viral infections, which proteins are preferentially presented by MHC molecules?

Which of the following is true regarding the antigen display function of MHC molecules?

Which of the following is true regarding the stability of MHC molecules on cell surfaces?

What is the mechanism by which class I MHC molecules acquire their peptides?

Why are MHC molecules able to present foreign antigens despite the presence of self antigens in an APC?

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