Questions and Answers
What is the primary mechanism of action of metronidazole?
Which condition is NOT commonly treated with metronidazole?
What is the bioavailability of metronidazole when taken orally?
Metronidazole belongs to which class of medications?
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Which of the following is a potential side effect of metronidazole?
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Study Notes
Metronidazole Overview
- Metronidazole is a synthetic antiprotozoal and antibacterial agent, chemically known as (l-β-hydroxyethyl)-2-methyl-5-nitroimidazole.
- It belongs to the nitroimidazole group, which includes related compounds like tinidazole.
Mechanism of Action
- Disrupts the DNA structure of bacteria and parasites, inhibiting their ability to multiply and survive.
Indications for Use in Dental Infections
- Effective for treating dental infections where anaerobic bacteria are implicated.
- Commonly prescribed for conditions like periodontal disease and oral abscesses.
Dosing and Administration
- Administered orally with approximately 80% bioavailability from the gastrointestinal tract.
- Dosage may vary based on the type and severity of the infection.
Side Effects and Drug Interactions
- Common side effects include nausea, dizziness, headache, and a metallic taste.
- Potential drug interactions with alcohol (can cause disulfiram-like reactions) and anticoagulants (increased bleeding risk).
Comparison with Other Antibiotics
- Metronidazole is often compared to other antibiotics like amoxicillin and clindamycin in terms of efficacy against anaerobic bacteria.
- Distinct mechanism and spectrum of activity, making it a preferred choice in certain bacterial infections.
Role in Post-Surgical Infection Prevention
- Used prophylactically to reduce infection risks after dental surgery, particularly in procedures involving high bacterial load.
- Effective in combination with other antibiotics to provide broader coverage against potential pathogens.
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Description
This quiz covers the essential aspects of metronidazole, including its definition, mechanism of action, and specific indications in dental infections. Participants will also review dosing, potential side effects, and drug interactions, along with a comparison to alternative antibiotics used in dental treatment. Engage with questions that deepen your understanding of this critical medication.
