Metronidazole Drug Information

Play an AI-generated podcast conversation about this lesson

What is the mechanism of action of Atovaquone (Mepron™)?

Inhibition of protein synthesis

Inhibition of DNA replication

Inhibition of cell wall synthesis

Inhibition of the mitochondrial respiratory chain (correct)

How is Chagas' disease primarily spread?

Through contaminated water

Through direct contact with an infected person

By the blood-sucking insect kissing bug (correct)

Via airborne transmission

What is the key characteristic of Atovaquone (Mepron™) that enhances its absorption?

Increased absorption with high protein meals

High fat solubility (correct)

Low fat solubility

High water solubility

Which parasite causes Chagas' disease?

Trypanosoma cruzi Signup and view all the answers

What is the chronic form of Chagas' disease that may lead to heart complications?

Heart attack Signup and view all the answers

How is African Trypanosomiasis (sleeping sickness) primarily transmitted?

By the tsetse fly Signup and view all the answers

What is the main cause of antibiotic-associated diarrhea?

Clostridium difficile Signup and view all the answers

What is the major metabolite of Metronidazole?

Hydroxymethyl analog (HM) Signup and view all the answers

What is the mechanism of action of Metronidazole?

Binding covalently to bacterial DNA Signup and view all the answers

What is the physicochemical property of Metronidazole that contributes to its weak base nature?

pKa of 2.5 Signup and view all the answers

What is the purpose of Diloxanide furoate in medication?

Treatment of asymptomatic amebiasis Signup and view all the answers

Which medication has a longer plasma half-life compared to Metronidazole?

Tinidazole Signup and view all the answers

What is the drug of choice for the treatment of amebiasis, giardiasis, and trichomoniasis?

Metronidazole Signup and view all the answers

What is the common cause of vaginitis that may also be caused by Trichomonas vaginalis?

Candida albicans Signup and view all the answers

Which protozoal infection is responsible for causing dysentery with blood and mucus in the stool?

Amebiasis Signup and view all the answers

Which of the following infections is mainly asymptomatic in males?

Trichomoniasis Signup and view all the answers

What is the most common cause of waterborne diarrhea in the USA?

Giardiasis Signup and view all the answers

Which drug is effective against amebiasis, giardiasis, and trichomoniasis and also has antibacterial activity?