Metronidazole Drug Information
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Questions and Answers

What is the mechanism of action of Atovaquone (Mepron™)?

  • Inhibition of protein synthesis
  • Inhibition of DNA replication
  • Inhibition of cell wall synthesis
  • Inhibition of the mitochondrial respiratory chain (correct)

    • How is Chagas' disease primarily spread?

  • Through contaminated water
  • Through direct contact with an infected person
  • By the blood-sucking insect kissing bug (correct)
  • Via airborne transmission

    • What is the key characteristic of Atovaquone (Mepron™) that enhances its absorption?

  • Increased absorption with high protein meals
  • High fat solubility (correct)
  • Low fat solubility
  • High water solubility

    • Which parasite causes Chagas' disease?

    <p>Trypanosoma cruzi</p> Signup and view all the answers

    What is the chronic form of Chagas' disease that may lead to heart complications?

    <p>Heart attack</p> Signup and view all the answers

    How is African Trypanosomiasis (sleeping sickness) primarily transmitted?

    <p>By the tsetse fly</p> Signup and view all the answers

    What is the main cause of antibiotic-associated diarrhea?

    <p>Clostridium difficile</p> Signup and view all the answers

    What is the major metabolite of Metronidazole?

    <p>Hydroxymethyl analog (HM)</p> Signup and view all the answers

    What is the mechanism of action of Metronidazole?

    <p>Binding covalently to bacterial DNA</p> Signup and view all the answers

    What is the physicochemical property of Metronidazole that contributes to its weak base nature?

    <p>pKa of 2.5</p> Signup and view all the answers

    What is the purpose of Diloxanide furoate in medication?

    <p>Treatment of asymptomatic amebiasis</p> Signup and view all the answers

    Which medication has a longer plasma half-life compared to Metronidazole?

    <p>Tinidazole</p> Signup and view all the answers

    What is the drug of choice for the treatment of amebiasis, giardiasis, and trichomoniasis?

    <p>Metronidazole</p> Signup and view all the answers

    What is the common cause of vaginitis that may also be caused by Trichomonas vaginalis?

    <p>Candida albicans</p> Signup and view all the answers

    Which protozoal infection is responsible for causing dysentery with blood and mucus in the stool?

    <p>Amebiasis</p> Signup and view all the answers

    Which of the following infections is mainly asymptomatic in males?

    <p>Trichomoniasis</p> Signup and view all the answers

    What is the most common cause of waterborne diarrhea in the USA?

    <p>Giardiasis</p> Signup and view all the answers

    Which drug is effective against amebiasis, giardiasis, and trichomoniasis and also has antibacterial activity?

    <p>Metronidazole</p> Signup and view all the answers

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