Metronidazole Drug Information
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Questions and Answers

What is the mechanism of action of Atovaquone (Mepronâ„¢)?

  • Inhibition of protein synthesis
  • Inhibition of DNA replication
  • Inhibition of cell wall synthesis
  • Inhibition of the mitochondrial respiratory chain (correct)

How is Chagas' disease primarily spread?

  • Through contaminated water
  • Through direct contact with an infected person
  • By the blood-sucking insect kissing bug (correct)
  • Via airborne transmission

What is the key characteristic of Atovaquone (Mepronâ„¢) that enhances its absorption?

  • Increased absorption with high protein meals
  • High fat solubility (correct)
  • Low fat solubility
  • High water solubility

Which parasite causes Chagas' disease?

<p>Trypanosoma cruzi (D)</p> Signup and view all the answers

What is the chronic form of Chagas' disease that may lead to heart complications?

<p>Heart attack (D)</p> Signup and view all the answers

How is African Trypanosomiasis (sleeping sickness) primarily transmitted?

<p>By the tsetse fly (D)</p> Signup and view all the answers

What is the main cause of antibiotic-associated diarrhea?

<p>Clostridium difficile (C)</p> Signup and view all the answers

What is the major metabolite of Metronidazole?

<p>Hydroxymethyl analog (HM) (D)</p> Signup and view all the answers

What is the mechanism of action of Metronidazole?

<p>Binding covalently to bacterial DNA (D)</p> Signup and view all the answers

What is the physicochemical property of Metronidazole that contributes to its weak base nature?

<p>pKa of 2.5 (A)</p> Signup and view all the answers

What is the purpose of Diloxanide furoate in medication?

<p>Treatment of asymptomatic amebiasis (B)</p> Signup and view all the answers

Which medication has a longer plasma half-life compared to Metronidazole?

<p>Tinidazole (B)</p> Signup and view all the answers

What is the drug of choice for the treatment of amebiasis, giardiasis, and trichomoniasis?

<p>Metronidazole (D)</p> Signup and view all the answers

What is the common cause of vaginitis that may also be caused by Trichomonas vaginalis?

<p>Candida albicans (C)</p> Signup and view all the answers

Which protozoal infection is responsible for causing dysentery with blood and mucus in the stool?

<p>Amebiasis (D)</p> Signup and view all the answers

Which of the following infections is mainly asymptomatic in males?

<p>Trichomoniasis (D)</p> Signup and view all the answers

What is the most common cause of waterborne diarrhea in the USA?

<p>Giardiasis (D)</p> Signup and view all the answers

Which drug is effective against amebiasis, giardiasis, and trichomoniasis and also has antibacterial activity?

<p>Metronidazole (D)</p> Signup and view all the answers

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