Metronidazole Flashcards
10 Questions
100 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the therapeutic class of Metronidazole?

  • Antihistamine
  • Analgesic
  • Anti-infective, antiprotozoan (correct)
  • Antibiotic

What is the pharmacologic class of Metronidazole?

Drug that disrupts nucleic acid synthesis

Metronidazole is effective against resistant forms of E. histolytica.

False (B)

Which of the following conditions is Metronidazole used to treat? (Select all that apply)

<p>Trichomoniasis (A), Amebiasis (C), Rosacea (D)</p> Signup and view all the answers

What are some common adverse effects of Metronidazole?

<p>Anorexia, nausea, diarrhea, dizziness, headache</p> Signup and view all the answers

Metronidazole can cause bone marrow suppression.

<p>True (A)</p> Signup and view all the answers

Metronidazole is contraindicated during the first trimester of _____

<p>pregnancy</p> Signup and view all the answers

The extended-release form of Metronidazole can be taken with food.

<p>False (B)</p> Signup and view all the answers

What is a significant drug interaction for Metronidazole?

<p>It interacts with oral anticoagulants to potentiate hypoprothrombinemia</p> Signup and view all the answers

What warning is associated with Metronidazole?

<p>It has a black box warning for carcinogenicity in lab animals (D)</p> Signup and view all the answers

Study Notes

Metronidazole Overview

  • Therapeutic Class: Anti-infective, antiprotozoan.
  • Pharmacologic Class: Disrupts nucleic acid synthesis.

Actions and Uses

  • Effective against intestinal and hepatic stages of amebiasis, with no significant resistance in E. histolytica.
  • Preferred medication for giardiasis and trichomoniasis.
  • Unique antibiotic activity against anaerobic bacteria, treating various infections (respiratory, bone, skin, CNS).
  • Topical formulations (MetroGel, Metro-Cream, MetroLotion) treat rosacea.
  • Helidac combines metronidazole with bismuth and tetracycline to target H. pylori in peptic ulcer disease.
  • Off-label use for pseudomembranous colitis and Crohn's disease.

Administration Alerts

  • Extended-release must be taken whole on an empty stomach.
  • Contraindicated during the first trimester of pregnancy; categorized as Pregnancy category B.

Adverse Effects

  • Common adverse effects include anorexia, nausea, diarrhea, dizziness, headache, dry mouth, and an unpleasant metallic taste.
  • Rarely, it may lead to bone marrow suppression.

Black Box Warning

  • Carcinogenic in laboratory animals; use restricted to approved indications.

Contraindications

  • Contraindicated in patients with trichomoniasis in the first trimester of pregnancy and those with hypersensitivity to metronidazole.
  • Should not be administered to patients with blood dyscrasias due to potential bone marrow suppression.

Interactions

  • Drug-Drug: Enhances anticoagulant effects, increasing risk of hypoprothrombinemia; may cause disulfiram reaction when combined with alcohol; can elevate lithium levels in patients on lithium therapy.
  • Lab Tests: Can decrease AST and ALT values; unknown effects with herbal/food interactions.
  • Overdose Treatment: No specific treatment protocol for overdose situations.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Description

Test your knowledge of Metronidazole, its therapeutic and pharmacologic classes, and its actions and uses. This quiz covers essential information about the medication's effectiveness against amebiasis and its mechanism of action.

More Like This

Metronidazole in Dental Infection Management
5 questions
Pharmacology of Metronidazole and Antibacterials
13 questions
Metronidazole: Anti-infective and Antibiotic
21 questions
Use Quizgecko on...
Browser
Browser