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What are the generic and trade names for Methylprednisolone?
What are the generic and trade names for Methylprednisolone?
- Dexamethasone / Decadron
- Prednisone / Deltasone
- Methylprednisolone / Solu-Medrol (correct)
- Hydrocortisone / Cortef
What classification does Methylprednisolone fall under?
What classification does Methylprednisolone fall under?
- Analgesic
- Antibiotic
- Antihistamine
- Corticosteroid (correct)
What is the mechanism of action for Methylprednisolone?
What is the mechanism of action for Methylprednisolone?
It diffuses across cell membranes, binds to DNA, regulates gene expression and inhibits inflammatory agents.
The onset time for Methylprednisolone is ______.
The onset time for Methylprednisolone is ______.
The peak effect of Methylprednisolone occurs after ______.
The peak effect of Methylprednisolone occurs after ______.
The duration of Methylprednisolone's effect lasts for ______.
The duration of Methylprednisolone's effect lasts for ______.
What are some indications for Methylprednisolone?
What are some indications for Methylprednisolone?
What is a major contraindication for Methylprednisolone?
What is a major contraindication for Methylprednisolone?
Name a side effect of Methylprednisolone.
Name a side effect of Methylprednisolone.
The recommended adult dose for Methylprednisolone is ______.
The recommended adult dose for Methylprednisolone is ______.
The maximum dose for pediatric patients of Methylprednisolone is ______.
The maximum dose for pediatric patients of Methylprednisolone is ______.
What precaution should be taken when administering Methylprednisolone?
What precaution should be taken when administering Methylprednisolone?
Which medications can interact with Methylprednisolone?
Which medications can interact with Methylprednisolone?
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Study Notes
Methylprednisolone Overview
- Generic/Trade Name: Methylprednisolone / Solu-Medrol
- Classification: Corticosteroid; serves as an anti-inflammatory agent.
Mechanism of Action
- Diffuses through cell membranes, binds to DNA.
- Regulates gene expression, increasing synthesis of proteins and enzymes that inhibit inflammatory agents.
- Functions as an immunosuppressant by inhibiting pro-inflammatory enzyme synthesis.
Pharmacokinetics
- Onset: 2-6 hours after administration.
- Peak effect occurs within 4-8 days.
- Duration of action ranges from 1-5 weeks.
- Half-life: Approximately 3.5 hours.
Indications
- Effective for allergic reactions and anaphylaxis.
- Used in the treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD).
Contraindications
- Hypersensitivity to methylprednisolone.
Side Effects
- Potential for fluid retention, congestive heart failure (CHF), hypertension (HTN).
- May cause abdominal distension, vertigo, headaches, nausea, malaise, and hiccups.
Dosage Guidelines
- Adult dosage: 125 mg, administered slowly via IV/IO.
- Pediatric dosage: 2 mg/kg, maximum dose of 125 mg, administered slowly via IV/IO.
Precautions
- Administer only one dose pre-hospital.
- Long-term use may lead to gastrointestinal bleeding, delayed wound healing, and suppression of adrenocortical steroids.
Drug-Drug Interactions
- Combination with Lasix and thiazide diuretics can enhance potassium excretion.
- Efficacy may be reduced when used with phenytoin, phenobarbital, or rifampin due to increased metabolism of steroids.
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