Methylprednisolone Acetate and Protein Formulations Quiz
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Questions and Answers

What is added to the sterile aqueous suspension to adjust tonicity?

  • Hydrochloric Acid
  • Sodium Chloride (correct)
  • Potassium Chloride
  • Sodium Hydroxide
  • Which structure of proteins can be disrupted if the higher order structure is disturbed?

  • Tertiary structure (correct)
  • Quaternary structure
  • Secondary structure
  • Primary structure
  • What can vigorous agitation cause in protein formulations?

  • Increase in solubility
  • Decrease in viscosity
  • Foaming and denaturation (correct)
  • Enhanced stability
  • What problem can arise from the loss of protein by adsorption to surfaces during the manufacturing process?

    <p>Loss of biological activity</p> Signup and view all the answers

    Which factor is critical to maintaining during the protein preparation process?

    <p>Temperature and pH</p> Signup and view all the answers

    Which biotech-derived product was the first one approved by the FDA?

    <p>Human insulin</p> Signup and view all the answers

    Why must large-volume parenteral solutions not contain bacteriostatic agents or other pharmaceutical additives?

    <p>Due to the large volumes administered</p> Signup and view all the answers

    Which of the following is a common use of large-volume parenteral solutions?

    <p>Replacing lost fluids and electrolytes</p> Signup and view all the answers

    Why should Dextrose Injection, USP not be administered simultaneously with blood through the same administration set?

    <p>Due to the possibility of pseudo agglutination or hemolysis</p> Signup and view all the answers

    What is the primary function of Sodium chloride & Dextrose injection?

    <p>To act as a fluids and electrolyte replenisher</p> Signup and view all the answers

    In which clinical condition should Sodium chloride injection be used with great care?

    <p>Congestive heart failure</p> Signup and view all the answers

    What percentage of Sodium chloride does Sodium chloride injection contain?

    <p>0.9%</p> Signup and view all the answers

    What is a common strategy to enhance the stability of proteins in organic solvents?

    <p>Adding additives such as other proteins, amino acids, and surfactants</p> Signup and view all the answers

    How can protein stability be improved using genetic engineering methods?

    <p>Modification of protein structure</p> Signup and view all the answers

    What is a characteristic of Small Volume Parenterals (SVP) as defined by the USP?

    <p>Packaged in containers labeled as containing 100 mL or less</p> Signup and view all the answers

    Which administration route can be used for Small Volume Parenterals?

    <p>IV bolus or IV push</p> Signup and view all the answers

    When are Large Volume Parenterals typically administered?

    <p>By IV infusion to replenish body fluids or provide nutrition</p> Signup and view all the answers

    What distinguishes Large Volume Parenterals from Small Volume Parenterals in terms of container size?

    <p>Large Volume Parenterals are packaged in containers containing more than 100 mL</p> Signup and view all the answers

    Which electrolyte is NOT mentioned as part of the total parenteral nutrition?

    <p>Iron</p> Signup and view all the answers

    What is a suitable condition for the use of total parenteral nutrition?

    <p>Undernourishment requiring surgery</p> Signup and view all the answers

    Which category of patients is mentioned as suitable for total nutrient admixtures?

    <p>Gastrointestinal patients</p> Signup and view all the answers

    What could be a disadvantage of using a three-in-one total nutrient admixture?

    <p>Obscuring precipitates</p> Signup and view all the answers

    What are the common standards for irrigation and dialysis solutions?

    <p>Clarity, sterile, pyrogen free</p> Signup and view all the answers

    What is the preferred method when a lipid emulsion is needed in total parenteral nutrition?

    <p>Mix it in a two-in-one admixture</p> Signup and view all the answers

    What distinguishes irrigation and dialysis solutions from other medications?

    <p>They are packaged in large containers for rapid pouring.</p> Signup and view all the answers

    Which of the following is an example of an irrigation solution?

    <p>Acetic acid irrigation, USP</p> Signup and view all the answers

    What is the purpose of Neomycin and Polymyxin B sulfates solution for irrigation, USP?

    <p>To act as a topical antibacterial in bladder irrigation</p> Signup and view all the answers

    Why must Ringer's irrigation, USP be labeled as 'NOT FOR INJECTION'?

    <p>Because it is intended to be used topically for irrigation</p> Signup and view all the answers

    In what form is Sodium chloride irrigation, USP employed?

    <p>As a topical solution for wounds</p> Signup and view all the answers

    What does Sterile water for irrigation, USP typically do?

    <p>Washes surgical debris and blood away</p> Signup and view all the answers

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