Methylprednisolone Acetate and Protein Formulations Quiz

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Questions and Answers

What is added to the sterile aqueous suspension to adjust tonicity?

  • Hydrochloric Acid
  • Sodium Chloride (correct)
  • Potassium Chloride
  • Sodium Hydroxide

Which structure of proteins can be disrupted if the higher order structure is disturbed?

  • Tertiary structure (correct)
  • Quaternary structure
  • Secondary structure
  • Primary structure

What can vigorous agitation cause in protein formulations?

  • Increase in solubility
  • Decrease in viscosity
  • Foaming and denaturation (correct)
  • Enhanced stability

What problem can arise from the loss of protein by adsorption to surfaces during the manufacturing process?

<p>Loss of biological activity (B)</p> Signup and view all the answers

Which factor is critical to maintaining during the protein preparation process?

<p>Temperature and pH (D)</p> Signup and view all the answers

Which biotech-derived product was the first one approved by the FDA?

<p>Human insulin (B)</p> Signup and view all the answers

Why must large-volume parenteral solutions not contain bacteriostatic agents or other pharmaceutical additives?

<p>Due to the large volumes administered (D)</p> Signup and view all the answers

Which of the following is a common use of large-volume parenteral solutions?

<p>Replacing lost fluids and electrolytes (C)</p> Signup and view all the answers

Why should Dextrose Injection, USP not be administered simultaneously with blood through the same administration set?

<p>Due to the possibility of pseudo agglutination or hemolysis (B)</p> Signup and view all the answers

What is the primary function of Sodium chloride & Dextrose injection?

<p>To act as a fluids and electrolyte replenisher (D)</p> Signup and view all the answers

In which clinical condition should Sodium chloride injection be used with great care?

<p>Congestive heart failure (A)</p> Signup and view all the answers

What percentage of Sodium chloride does Sodium chloride injection contain?

<p>0.9% (C)</p> Signup and view all the answers

What is a common strategy to enhance the stability of proteins in organic solvents?

<p>Adding additives such as other proteins, amino acids, and surfactants (C)</p> Signup and view all the answers

How can protein stability be improved using genetic engineering methods?

<p>Modification of protein structure (A)</p> Signup and view all the answers

What is a characteristic of Small Volume Parenterals (SVP) as defined by the USP?

<p>Packaged in containers labeled as containing 100 mL or less (D)</p> Signup and view all the answers

Which administration route can be used for Small Volume Parenterals?

<p>IV bolus or IV push (A)</p> Signup and view all the answers

When are Large Volume Parenterals typically administered?

<p>By IV infusion to replenish body fluids or provide nutrition (D)</p> Signup and view all the answers

What distinguishes Large Volume Parenterals from Small Volume Parenterals in terms of container size?

<p>Large Volume Parenterals are packaged in containers containing more than 100 mL (B)</p> Signup and view all the answers

Which electrolyte is NOT mentioned as part of the total parenteral nutrition?

<p>Iron (C)</p> Signup and view all the answers

What is a suitable condition for the use of total parenteral nutrition?

<p>Undernourishment requiring surgery (D)</p> Signup and view all the answers

Which category of patients is mentioned as suitable for total nutrient admixtures?

<p>Gastrointestinal patients (A)</p> Signup and view all the answers

What could be a disadvantage of using a three-in-one total nutrient admixture?

<p>Obscuring precipitates (A)</p> Signup and view all the answers

What are the common standards for irrigation and dialysis solutions?

<p>Clarity, sterile, pyrogen free (A)</p> Signup and view all the answers

What is the preferred method when a lipid emulsion is needed in total parenteral nutrition?

<p>Mix it in a two-in-one admixture (D)</p> Signup and view all the answers

What distinguishes irrigation and dialysis solutions from other medications?

<p>They are packaged in large containers for rapid pouring. (C)</p> Signup and view all the answers

Which of the following is an example of an irrigation solution?

<p>Acetic acid irrigation, USP (A)</p> Signup and view all the answers

What is the purpose of Neomycin and Polymyxin B sulfates solution for irrigation, USP?

<p>To act as a topical antibacterial in bladder irrigation (C)</p> Signup and view all the answers

Why must Ringer's irrigation, USP be labeled as 'NOT FOR INJECTION'?

<p>Because it is intended to be used topically for irrigation (B)</p> Signup and view all the answers

In what form is Sodium chloride irrigation, USP employed?

<p>As a topical solution for wounds (C)</p> Signup and view all the answers

What does Sterile water for irrigation, USP typically do?

<p>Washes surgical debris and blood away (D)</p> Signup and view all the answers

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