7 Questions
What is the primary physiological regulator of flux through PDH and the rate of glucose oxidation in the heart?
FA oxidation
What inhibits PDH activity?
High rate of FA oxidation
What increases the uptake and oxidation of glucose and lactate in the heart?
Inhibition of FA oxidation
What improves cardiac efficiency by lowering acetyl CoA and/or NADH levels in the mitochondria?
Inhibition of FA oxidation
Which hormonal factor is involved in the regulation of substrate selection in cardiac metabolism?
Catecholamines
What is another term for the Glucose/FA cycle involved in substrate selection regulation?
Randle cycle
Which compound allosterically inhibits PDH?
Acetyl CoA
Explore the substrates used for oxidative generation of ATP in the heart and how hormonal control, workload, and oxygen supply influence the process. Test your knowledge on the fuels that power the metabolism of a normal heart.
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