Metabolism of the Normal Heart
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Questions and Answers

What is the primary physiological regulator of flux through PDH and the rate of glucose oxidation in the heart?

  • FA oxidation (correct)
  • ATP
  • Insulin
  • Catecholamines

    • What inhibits PDH activity?

  • High rate of FA oxidation (correct)
  • Increased ATP levels
  • Low levels of glucose
  • Presence of insulin

    • What increases the uptake and oxidation of glucose and lactate in the heart?

  • Activation of PDH kinase
  • Elevated NADH levels
  • Increased acetyl CoA levels
  • Inhibition of FA oxidation (correct)

    • What improves cardiac efficiency by lowering acetyl CoA and/or NADH levels in the mitochondria?

    <p>Inhibition of FA oxidation</p> Signup and view all the answers

    Which hormonal factor is involved in the regulation of substrate selection in cardiac metabolism?

    <p>Catecholamines</p> Signup and view all the answers

    What is another term for the Glucose/FA cycle involved in substrate selection regulation?

    <p>Randle cycle</p> Signup and view all the answers

    Which compound allosterically inhibits PDH?

    <p>Acetyl CoA</p> Signup and view all the answers

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