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Questions and Answers
What is the primary physiological regulator of flux through PDH and the rate of glucose oxidation in the heart?
What is the primary physiological regulator of flux through PDH and the rate of glucose oxidation in the heart?
- FA oxidation (correct)
- ATP
- Insulin
- Catecholamines
What inhibits PDH activity?
What inhibits PDH activity?
- High rate of FA oxidation (correct)
- Increased ATP levels
- Low levels of glucose
- Presence of insulin
What increases the uptake and oxidation of glucose and lactate in the heart?
What increases the uptake and oxidation of glucose and lactate in the heart?
- Activation of PDH kinase
- Elevated NADH levels
- Increased acetyl CoA levels
- Inhibition of FA oxidation (correct)
What improves cardiac efficiency by lowering acetyl CoA and/or NADH levels in the mitochondria?
What improves cardiac efficiency by lowering acetyl CoA and/or NADH levels in the mitochondria?
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Which hormonal factor is involved in the regulation of substrate selection in cardiac metabolism?
Which hormonal factor is involved in the regulation of substrate selection in cardiac metabolism?
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What is another term for the Glucose/FA cycle involved in substrate selection regulation?
What is another term for the Glucose/FA cycle involved in substrate selection regulation?
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Which compound allosterically inhibits PDH?
Which compound allosterically inhibits PDH?
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