Metabolism of Pyruvate and Acetyl-CoA Functions
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Questions and Answers

What is the main molecule that pyruvate is converted into in the mitochondrion?

  • Lactate
  • Acetyl-COA (correct)
  • Oxaloacetate
  • Succinate
  • Which gas is necessary for pyruvate to enter the mitochondrion and be transformed into Acetyl-COA?

  • CO2
  • N2
  • O2 (correct)
  • H2
  • What process allows pyruvate to move into the mitochondrion?

  • Pinocytosis
  • Facilitated Diffusion
  • Active Transport (correct)
  • Diffusion
  • What occurs to pyruvate during its transformation in the mitochondrion?

    <p>Oxidative Decarboxylation</p> Signup and view all the answers

    Which of the following best describes the end product of glycolysis?

    <p>Pyruvate</p> Signup and view all the answers

    What is the primary function associated with the process described in the content?

    <p>Formation of amino acids</p> Signup and view all the answers

    Which amino acid is involved in the transamination process as mentioned?

    <p>Glutamate</p> Signup and view all the answers

    Which process is primarily linked to the formation of glutamate?

    <p>Transamination</p> Signup and view all the answers

    What is α-Ketoglutarate's main role in the content?

    <p>A precursor for specific amino acids</p> Signup and view all the answers

    Which two components are specifically mentioned in relation to anabolic functions?

    <p>Amino acids and α-Ketoglutarate</p> Signup and view all the answers

    What type of gradient is created across the inner mitochondrial membrane?

    <p>Electrical gradient</p> Signup and view all the answers

    Where are there more positive charges during the generation of the electrical gradient?

    <p>On the outside of the membrane</p> Signup and view all the answers

    What effect does the electrical gradient have on cellular processes?

    <p>It promotes ion transport across the membrane.</p> Signup and view all the answers

    Which statement accurately describes the charge difference across the mitochondrial membrane?

    <p>The outer membrane has more positive charges compared to the inner membrane.</p> Signup and view all the answers

    Which component primarily contributes to the establishment of the electrical gradient in mitochondria?

    <p>Protons (H+ ions)</p> Signup and view all the answers

    What is the primary molecule formed from the interaction of ribulose-5-phosphate in the non-oxidative phase?

    <p>Glucose-6-phosphate</p> Signup and view all the answers

    How many molecules of ribulose-5-phosphate are mentioned as participating in the non-oxidative phase?

    <p>3</p> Signup and view all the answers

    Which of the following molecules is NOT formed during the non-oxidative phase?

    <p>Ribulose-1,5-bisphosphate</p> Signup and view all the answers

    What type of phase is described in the content concerning the conversion of molecules?

    <p>Non-oxidative reversible phase</p> Signup and view all the answers

    Which two types of molecules are generated from the conversion involving ribulose-5-phosphate?

    <p>Glyc-3-phosphate and glucose-6-phosphate</p> Signup and view all the answers

    What role does glycogen synthase play in glycogen synthesis?

    <p>It helps in the elongation of glycogen by adding UDP-G molecules.</p> Signup and view all the answers

    How many glucose units does glycogen synthase elongate branches by during glycogen synthesis?

    <p>12-14 glucose units.</p> Signup and view all the answers

    What type of bonds does glycogen synthase create during glycogen elongation?

    <p>α1-4 glycosidic bonds.</p> Signup and view all the answers

    What molecule is primarily responsible for initiating the elongation of glycogen?

    <p>UDP-glucose (UDP-G).</p> Signup and view all the answers

    What is primarily formed by the action of glycogen synthase?

    <p>Longer glycogen chains.</p> Signup and view all the answers

    Study Notes

    Pyruvate Transport and Oxidative Decarboxylation

    • Pyruvate, the end product of glycolysis, is transported into the mitochondrion by a special pyruvate transporter in the presence of oxygen.
    • Inside the mitochondrion, pyruvate undergoes oxidative decarboxylation, converting it into Acetyl-CoA.
    • This process involves the removal of a carbon dioxide molecule from pyruvate.

    Anabolic Functions of Acetyl-CoA

    • Acetyl-CoA plays a crucial role in the formation of amino acids.
    • One of the primary amino acids produced is α-ketoglutarate, which is formed through a process called transamination involving Glutamate.

    Mitochondrial Membrane Gradient and Non-Oxidative Phase

    • The oxidative decarboxylation of pyruvate creates an electrical gradient across the inner mitochondrial membrane.
    • This gradient results in a higher concentration of positive charges on the outside of the membrane compared to the inside.
    • The non-oxidative phase of the pentose phosphate pathway is reversible and involves the interconversion of molecules.
    • Three molecules of ribulose-5-phosphate are converted into two molecules of glucose-6-phosphate and one molecule of glyceraldehyde-3-phosphate.

    Glycogen Synthesis

    • Glycogen synthase is a key enzyme involved in the synthesis of glycogen.
    • UDP-glucose molecules are added to a glycogen primer, leading to the elongation of α1-4 branches up to 12-14 glucose units.

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    Lec 3 Biochemistry PDF

    Description

    Explore the biochemical pathways of pyruvate transport and its conversion to Acetyl-CoA within mitochondria. This quiz covers the roles of Acetyl-CoA in amino acid formation and the significance of the mitochondrial membrane potential. Test your knowledge on these essential metabolic processes.

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