Metabolism of Free Fatty Acids Lecture Summary
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Questions and Answers

Which molecule transports free fatty acids to tissues like muscle for energy production?

  • Glucose
  • Serum albumin (correct)
  • Glycerol
  • Insulin
  • Why can't plasma free fatty acids be used for fuel by red blood cells?

  • Plasma free fatty acids are too large for red blood cells to absorb
  • Red blood cells lack mitochondria (correct)
  • Red blood cells have a low affinity for fatty acids
  • Free fatty acids are toxic to red blood cells
  • In which organelle are fatty acids oxidized for energy production?

  • Lysosome
  • Golgi apparatus
  • Endoplasmic reticulum
  • Mitochondria (correct)
  • What is the fate of over 50% of fatty acids released from adipose tissue?

    <p>Reesterified to glycerol 3-phosphate</p> Signup and view all the answers

    Under what conditions does beta-oxidation of fatty acids increase?

    <p>During prolonged fasting</p> Signup and view all the answers

    Which step must occur for beta-oxidation of fatty acids to take place?

    <p>Activation of fatty acids to acyl CoA derivatives</p> Signup and view all the answers

    What is the primary form in which fatty acids are stored in white adipose tissue?

    <p>Triacylglycerols (TAGs)</p> Signup and view all the answers

    What enzyme initiates the process of lipolysis by generating diacylglycerol?

    <p>Adipose Triglyceride Lipase (ATGL)</p> Signup and view all the answers

    What is the preferred substrate for Hormone Sensitive Lipase (HSL) in the process of lipolysis?

    <p>Diacylglycerol</p> Signup and view all the answers

    Which hormones activate the process of lipolysis?

    <p>Catecholamines</p> Signup and view all the answers

    What are the end products of lipolysis?

    <p>Glycerol and Free fatty acids</p> Signup and view all the answers

    How many kilocalories per gram are yielded from the complete oxidation of fatty acids, compared to proteins or carbohydrates?

    <p>$9$ kcal/g fat</p> Signup and view all the answers

    What is the first step in the activation of fatty acids upon entering a cell?

    <p>Conversion to acyl CoA</p> Signup and view all the answers

    Which enzyme is responsible for converting fatty acids to their active form CoA derivative in the cytosol?

    <p>Fatty acyl CoA synthetase</p> Signup and view all the answers

    Why does translocation of fatty acids across the inner mitochondrial membrane occur?

    <p>To access the enzymes of beta-oxidation in the mitochondrial matrix</p> Signup and view all the answers

    In a-oxidation of fatty acids, what is released one at a time during the process?

    <p>Terminal carboxyl as CO2</p> Signup and view all the answers

    Which organelle is involved in omega (ω) oxidation of fatty acids?

    <p>Endoplasmic reticulum</p> Signup and view all the answers

    What is required for the omega oxidation of fatty acids to take place?

    <p>Cytochrome p450, NADPH, and molecular O2</p> Signup and view all the answers

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