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Questions and Answers
What is the consequence of fatty acids being oxidized in the liver with the inactivation of PDH?
What is the consequence of fatty acids being oxidized in the liver with the inactivation of PDH?
- Formation of fructose 6-phosphate
- Conversion of pyruvate to acetyl CoA
- Production of fructose 1,6-bisphosphate
- Conversion of pyruvate to OAA (correct)
How is pyruvate carboxylase activated?
How is pyruvate carboxylase activated?
- By the stimulation of glucagon
- By the binding of acetyl CoA (correct)
- By the phosphorylation of pyruvate
- By the presence of NADH
What is a severe consequence of PEPCK deficiency?
What is a severe consequence of PEPCK deficiency?
- Fatty infiltration of the liver and kidney
- Optic atrophy (correct)
- Hyperglycemia
- Cerebral atrophy
What leads to the phosphorylation and inactivation of Pyruvate Kinase?
What leads to the phosphorylation and inactivation of Pyruvate Kinase?
How is transcription of the gene encoding PEPCK stimulated?
How is transcription of the gene encoding PEPCK stimulated?
What induces increased production of PEPCK messenger RNA (mRNA)?
What induces increased production of PEPCK messenger RNA (mRNA)?
What is the consequence of deficient glucose 6-phosphatase activity in von Gierke disease?
What is the consequence of deficient glucose 6-phosphatase activity in von Gierke disease?
Which enzyme is responsible for converting pyruvate to phosphoenolpyruvate (PEP) in gluconeogenesis?
Which enzyme is responsible for converting pyruvate to phosphoenolpyruvate (PEP) in gluconeogenesis?
What is the main clinical feature associated with deficiency of PEPCK (phosphoenolpyruvate carboxykinase)?
What is the main clinical feature associated with deficiency of PEPCK (phosphoenolpyruvate carboxykinase)?
What activates pyruvate carboxylase?
What activates pyruvate carboxylase?
Which enzyme is inhibited by glucagon via cAMP in the pathway shown?
Which enzyme is inhibited by glucagon via cAMP in the pathway shown?
What induces phosphoenolpyruvate carboxykinase (PEPCK) activity?
What induces phosphoenolpyruvate carboxykinase (PEPCK) activity?
What is a futile cycle in the context of gluconeogenesis?
What is a futile cycle in the context of gluconeogenesis?
What effect does increased glucagon and decreased insulin have on fatty acids?
What effect does increased glucagon and decreased insulin have on fatty acids?
Which enzyme catalyzes the conversion of pyruvate to oxaloacetate in gluconeogenesis?
Which enzyme catalyzes the conversion of pyruvate to oxaloacetate in gluconeogenesis?
What are the clinical features associated with PEPCK deficiency?
What are the clinical features associated with PEPCK deficiency?
Which enzyme is responsible for regulating the conversion of phosphoenolpyruvate to pyruvate in gluconeogenesis?
Which enzyme is responsible for regulating the conversion of phosphoenolpyruvate to pyruvate in gluconeogenesis?
What is the effect of glucagon on the induction of PEPCK?
What is the effect of glucagon on the induction of PEPCK?
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