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Metabolic Pathways Quiz

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Questions and Answers

What is the consequence of fatty acids being oxidized in the liver with the inactivation of PDH?

Formation of fructose 6-phosphate

Conversion of pyruvate to acetyl CoA

Production of fructose 1,6-bisphosphate

Conversion of pyruvate to OAA (correct)

How is pyruvate carboxylase activated?

By the stimulation of glucagon

By the binding of acetyl CoA (correct)

By the phosphorylation of pyruvate

By the presence of NADH

What is a severe consequence of PEPCK deficiency?

Fatty infiltration of the liver and kidney

Optic atrophy (correct)

Hyperglycemia

Cerebral atrophy

What leads to the phosphorylation and inactivation of Pyruvate Kinase?

Action of protein kinase A Signup and view all the answers

How is transcription of the gene encoding PEPCK stimulated?

By glucocorticoid–protein complexes Signup and view all the answers

What induces increased production of PEPCK messenger RNA (mRNA)?

Increased cAMP levels Signup and view all the answers

What is the consequence of deficient glucose 6-phosphatase activity in von Gierke disease?

Intracellular accumulation of glucose 6-phosphate Signup and view all the answers

Which enzyme is responsible for converting pyruvate to phosphoenolpyruvate (PEP) in gluconeogenesis?

Pyruvate carboxylase Signup and view all the answers

What is the main clinical feature associated with deficiency of PEPCK (phosphoenolpyruvate carboxykinase)?

Lethargy and seizures Signup and view all the answers

What activates pyruvate carboxylase?

Acetyl CoA Signup and view all the answers

Which enzyme is inhibited by glucagon via cAMP in the pathway shown?

Pyruvate kinase Signup and view all the answers

What induces phosphoenolpyruvate carboxykinase (PEPCK) activity?

Glucagon via cAMP Signup and view all the answers

What is a futile cycle in the context of gluconeogenesis?

A cycle that continuously recycles substrates and products with a net consumption of energy and no useful result Signup and view all the answers

What effect does increased glucagon and decreased insulin have on fatty acids?

Stimulates the release of fatty acids from adipose tissue Signup and view all the answers

Which enzyme catalyzes the conversion of pyruvate to oxaloacetate in gluconeogenesis?

Pyruvate carboxylase Signup and view all the answers

What are the clinical features associated with PEPCK deficiency?

Hypoglycemia and lactic acidosis Signup and view all the answers

Which enzyme is responsible for regulating the conversion of phosphoenolpyruvate to pyruvate in gluconeogenesis?

PEPCK Signup and view all the answers

What is the effect of glucagon on the induction of PEPCK?

Stimulation of PEPCK induction Signup and view all the answers