60 Questions
Which of the following symptoms is commonly associated with metabolic muscle diseases?
Exercise intolerance
Which of the following is a biochemical abnormality commonly seen in metabolic muscle diseases?
Elevated CK
Which genetic mutation is commonly associated with Duchenne muscular dystrophy?
Dystrophin gene
Which of the following is a common symptom of myasthenia gravis?
All of the above
Which marker is a specific indicator of bone resorption?
CTX
Which marker is a fairly good indicator of bone formation?
P1NP
Which of the following is a use of bone turnover markers (BTM)?
Predicting fracture risk
Which of the following is a symptom of metabolic muscle diseases?
Muscle pain after exercise
What is the most common cause of rhabdomyolysis?
Injury
What is the main component of skeletal muscle?
Proteins
What is the role of myoglobin in rhabdomyolysis-induced renal failure?
Increases urine concentration
Which of the following is not a cause of increased creatine kinase (CK) levels?
Myotonia
What is the most appropriate management for hypovolemia in rhabdomyolysis?
Fluid replacement
Which of the following is a characteristic of metabolic muscle diseases?
Exercise intolerance
Which of the following is NOT a biochemical marker of muscle damage?
Troponin
Which of the following is NOT a cause of skeletal muscle disease?
Metabolic bone diseases
Which of the following is NOT a non-metabolic cause of muscular diseases?
Metabolic myopathies
Which of the following is NOT a genetic metabolic disorder associated with muscle disease?
Hyperthyroidism
Which of the following is a bone-turnover marker?
Alkaline Phosphatase (ALP)
Which of the following is NOT a rheumatological disease?
Hyperadrenalism
Which of the following is NOT a metabolic bone disease?
Hyperthyroidism
Which laboratory investigations are commonly used in the diagnosis of osteoporosis?
TFT, PTH, 25(OH)D
What are the common secondary causes of osteoporosis?
Endocrine malignancy, connective tissue disease, hyperparathyroidism
Which radiology technique is commonly used in the diagnosis of osteoporosis?
DEXA
What can bone turnover markers (BTM) tell you about osteoporosis?
Treatment complications
What is the aim in the treatment of gout?
Decrease urate levels
What percentage of adults are affected by gout?
1%
Which of the following is NOT a common secondary cause of osteoporosis?
Marfan syndrome
Which laboratory investigation is commonly used to monitor therapy for osteoporosis?
Bone turnover markers (BTM)
Which of the following is NOT a common anabolic or anti-resorptive therapy for osteoporosis?
Gastrointestinal disease
What is the marker commonly used to demonstrate muscle damage?
Creatine kinase
What is the specific marker for cardiac muscle damage?
Troponin
Which of the following is NOT a cause of muscle disease?
Fatty acid oxidation
Which of the following is a non-metabolic cause of muscle disease?
Inflammation
Which of the following is a symptom commonly associated with mitochondrial diseases?
Hearing loss
Which of the following is a common symptom of fatty acid oxidation defects?
Muscle weakness
Which of the following tests is commonly used to diagnose metabolic disorders?
Lactate
What is the main purpose of testing lactate levels in a metabolic crisis?
To assess energy production in cells
Which of the following is a common cause of rhabdomyolysis?
Excessive exercise
What is the main component released into the circulation during rhabdomyolysis?
Myoglobin
Which of the following is NOT a metabolic muscle disease?
Rhabdomyolysis
What is the most appropriate management for hypovolemia in rhabdomyolysis?
Fluid replacement
Which of the following is a potential cause of rhabdomyolysis-induced renal failure?
High uric acid levels
Which of the following is a potential complication of compartment syndrome?
Permanent muscle damage
Which of the following is NOT a recommended management strategy for rhabdomyolysis?
Colonization with vitamin C
Which of the following is a potential cause of increased creatine kinase (CK) levels?
Muscle injury
Which of the following is a common symptom of metabolic muscle diseases?
Exercise intolerance
Which of the following is NOT a genetic metabolic disorder associated with muscle disease?
Polymyositis
Which of the following is a characteristic of metabolic muscle diseases?
Symmetrical muscle weakness
Which laboratory investigation is commonly used to monitor therapy for osteoporosis?
Bone turnover markers (BTMs)
Which of the following conditions is characterized by antibodies to the acetylcholine receptor?
Myasthenia gravis
What is the role of myoglobin in rhabdomyolysis-induced renal failure?
It can cause kidney damage
Which of the following is NOT a symptom commonly associated with metabolic muscle diseases?
Twitching muscles
What is the main component of skeletal muscle?
Actin
Which of the following conditions is characterized by weak muscles despite their large appearance?
Muscle fibrosis
Which of the following is a common secondary cause of osteoporosis?
Hormonal imbalance
Which type of muscle is NOT discussed in this module?
Smooth muscle
According to the text, why is it interesting to study the biochemistry of the musculoskeletal system in isolation?
It helps make more sense when seeing patients in clinic
What is the main aim in the treatment of gout?
All of the above
Which of the following is NOT a common symptom of myasthenia gravis?
Muscle stiffness
Test your knowledge on metabolic muscle diseases and their symptoms, including general muscle weakness, exercise intolerance, hearing loss, diabetes, and short stature. Learn about maternal inheritance and other related conditions like MERRF and Kearns-Sayre. Explore the causes of metabolic muscle diseases, including defects of fatty acid oxidation and lipid storage disorders. Challenge yourself with questions on muscle weakness, pain, myoglobinuria, and the onset of symptoms after exercise.
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