Thyroid Function Tests and Hypothalamic-Pituitary-Thyroid Axis Quiz
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Questions and Answers

Which of the following is true regarding primary hypothyroidism?

  • Plasma free and total T4 and T3 levels are increased
  • Thyroid stimulating antibody are directed against TSH receptor on thyroid cells
  • TSH,T4, and T3 are all decreased
  • Plasma [TSH] increases (correct)
  • What is a characteristic feature of secondary or tertiary hypothyroidism?

  • Thyroid stimulating antibody are directed against TSH receptor on thyroid cells
  • Plasma free and total T4 and T3 levels are increased
  • TSH,T4, and T3 are all decreased (correct)
  • Plasma [TSH] increases
  • Which statement is true about medications that interfere with thyroid function testing?

  • Biotin can interfere with measurement of thyroid hormones in the lab (correct)
  • Estrogens cause a decrease in the level of binding proteins
  • Biotin should be taken for 2 days before blood is drawn for testing
  • Estrogens result in normal levels of total T4 and T3
  • What is the purpose of determining the presence of autoimmune thyroid diseases such as Graves’ disease or Hashimoto’s thyroiditis?

    <p>To establish the presence of elevated thyroid antibodies despite normal TSH</p> Signup and view all the answers

    What is a characteristic feature of primary hyperthyroidism?

    <p>Plasma free and total T4 and T3 levels are increased</p> Signup and view all the answers

    Which test is often considered the diagnostic 'gold standard' for thyroid disease?

    <p>Thyroid Stimulating Hormone (TSH) test</p> Signup and view all the answers

    What is the effect of increased TBG level on the concentrations of total T4 and T3?

    <p>It increases the concentrations of total T4 and T3</p> Signup and view all the answers

    Which test provides a more reliable diagnosis of thyroid dysfunction than measurement of total T4 and T3?

    <p>Free T3 and T4 test</p> Signup and view all the answers

    In primary hyperthyroidism, what are the levels of T4, T3, and TSH due to feedback inhibition?

    <p>$T4$ and $T3$ are increased, $TSH$ is decreased</p> Signup and view all the answers

    What is the effect of a normal TSH level on some patients with ongoing symptoms?

    <p>It does not exclude the possibility of thyroid disease</p> Signup and view all the answers

    In primary hypothyroidism, both T4 and T3 levels are decreased, and TSH levels are increased.

    <p>True</p> Signup and view all the answers

    Elevated thyroid antibodies always indicate the presence of autoimmune thyroid diseases such as Graves’ disease or Hashimoto’s thyroiditis, despite a 'normal' TSH level.

    <p>False</p> Signup and view all the answers

    Secondary hypothyroidism is characterized by decreased levels of TSH, T4, and T3.

    <p>True</p> Signup and view all the answers

    Primary hyperthyroidism is characterized by decreased plasma TSH levels due to feedback inhibition on the pituitary.

    <p>False</p> Signup and view all the answers

    Estrogens, such as those found in birth control pills, can cause high levels of total T4 and T3 due to their effect on binding proteins.

    <p>True</p> Signup and view all the answers

    TSH level in the blood is not a reliable test for thyroid status for all patients with ongoing symptoms.

    <p>True</p> Signup and view all the answers

    Total T4 and total T3 are more reliable for diagnosing thyroid dysfunction than free T3 and T4.

    <p>False</p> Signup and view all the answers

    Changes in TBG level do not affect the concentrations of total T4 and total T3 in plasma.

    <p>False</p> Signup and view all the answers

    Thyroid antibody tests are used to determine the presence of autoimmune thyroid diseases such as Graves’ disease or Hashimoto’s thyroiditis.

    <p>True</p> Signup and view all the answers

    In primary hyperthyroidism, both T4 and T3 levels are decreased, and TSH level is increased due to feedback inhibition.

    <p>False</p> Signup and view all the answers

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