Metabolic Disorders Quiz: Lipoid Proteinosis and Systemic Amyloidosis
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Questions and Answers

What is the treatment of choice for lipoid proteinosis causing hoarseness of voice?

  • Acitretin (correct)
  • Steroid
  • Chemo
  • Anti siRNA
  • What genetic mutation is associated with Legius syndrome, which presents without tumors, freckles, lipoma, macrocephaly, and ADHD?

  • SPRED1 gene mutation (correct)
  • Fibrous dysplasia gene mutation
  • GNAS mutation
  • NF1 gene mutation
  • In a case of severe itchy macular hyperpigmentation on the back (macular amyloidosis), what investigation would be most appropriate?

  • Blood PTN fixation or detection
  • Congo red (correct)
  • Fat aspiration
  • Calcitonin level or thyroid scan
  • What would be the next step for a patient suspected of systemic amyloidosis?

    <p>Serum protein electrophoresis</p> Signup and view all the answers

    What is the next step for a female patient with macular amyloidosis?

    <p>Consult an endocrinologist</p> Signup and view all the answers

    In a pediatric patient with erythema and bone pain, histological findings of epithelioid granuloma and few lymphocytes point to a gene defect associated with which syndrome?

    <p>TNFR1 syndrome</p> Signup and view all the answers

    What gene defect is associated with Fabry's disease?

    <p>GLA gene</p> Signup and view all the answers

    A male patient with an erythematous rash and bone pain should have a bone x-ray performed on which site if the skull or cranium is not present?

    <p>Spine</p> Signup and view all the answers

    What is the most common association of macular amyloidosis?

    <p>No known specific association</p> Signup and view all the answers

    What mutation is responsible for causing Langerhans cell histiocytosis?

    <p>Mutation in BRAF gene</p> Signup and view all the answers

    In a patient with cutaneous amyloidosis, what organ association is commonly seen?

    <p>(Renal) kidney involvement</p> Signup and view all the answers

    (Tubers xanthoma) bilateral nodules on the Achilles tendon are typically associated with an elevation in which investigation?

    <p>(Cholesterol) serum cholesterol levels</p> Signup and view all the answers

    (Angiokeratoma) presenting with hyperkeratosis and rete ridges encircling dilated vessels in the papillary dermis points to a defect in which enzyme?

    <p>(Galactosidase A) alpha-galactosidase A</p> Signup and view all the answers

    In a patient with neurofibromatosis, what association is commonly seen?

    <p>Pheochromocytoma development</p> Signup and view all the answers

    In a case of Wilson's disease, what would you expect to find in the epidermis?

    <p>Elastic fiber accumulation</p> Signup and view all the answers

    In a patient with Wilson's disease, what would you expect to find in the epidermis?

    <p>Elastic fibers</p> Signup and view all the answers

    In a case of severe itchy macular hyperpigmentation on the back (macular amyloidosis), what investigation would be most appropriate?

    <p>Bone marrow biopsy</p> Signup and view all the answers

    A male patient with an erythematous rash and bone pain should have a bone x-ray performed on which site if the skull or cranium is not present?

    <p>Spine</p> Signup and view all the answers

    In a patient with cutaneous amyloidosis, what organ association is commonly seen?

    <p>Renal impairment</p> Signup and view all the answers

    (Tubers xanthoma) bilateral nodules on the Achilles tendon are typically associated with an elevation in which investigation?

    <p>Cholesterol level</p> Signup and view all the answers

    (Angiokeratoma) presenting with hyperkeratosis and rete ridges encircling dilated vessels in the papillary dermis points to a defect in which enzyme?

    <p>Galactosidase A</p> Signup and view all the answers

    In a case of Wilson's disease, what will you expect to find in the epidermis?

    <p>Elastic fibers</p> Signup and view all the answers

    In a pediatric patient with erythema and bone pain, histological findings of epithelioid granuloma and few lymphocytes point to a gene defect associated with which syndrome?

    <p>ACE Fabry's disease defect (picture)</p> Signup and view all the answers

    A female patient with macular amyloidosis would most likely require what investigation next?

    <p>Immunofixation</p> Signup and view all the answers

    A child with porphyria would most likely benefit from which treatment approach?

    <p>Phlebotomy</p> Signup and view all the answers

    A patient with skin-colored papules and elastic skin on the neck and angoid streaks on retina should consider taking which action next?

    <p>Start Biologic</p> Signup and view all the answers

    What investigation would be most appropriate for a patient with sever itchy macular hyperpigmentation on the back (macular amyloidosis)?

    <p>Congo red</p> Signup and view all the answers

    For a 10-year-old child with normal findings but scars on knuckles, which porphyria investigation would be expected to be positive and which negative?

    <p>Urine porphyrin: negative, Blood porphyrin: positive</p> Signup and view all the answers

    In a case of severe itchy macular hyperpigmentation on the back (macular amyloidosis), what would be the most appropriate association?

    <p>Systemic amyloidosis</p> Signup and view all the answers

    In a case of lipoid proteinosis causing hoarseness of voice, what is the most appropriate treatment?

    <p>Chemo Steroid + Melphalan</p> Signup and view all the answers

    In a patient with neurofibromatosis, what association is commonly seen?

    <p>Café au lait macules</p> Signup and view all the answers

    What association would be commonly found in a patient with Legius syndrome caused by SPRED1 gene?

    <p>Macrocephaly</p> Signup and view all the answers

    Which investigation is typically elevated in a patient with tuberous xanthoma (bilateral nodules on the Achilles tendon)?

    <p>Calcitonin level</p> Signup and view all the answers

    (Angiokeratoma) presenting with hyperkeratosis and rete ridges encircling dilated vessels in the papillary dermis points to a defect in which enzyme?

    <p>alpha-galactosidase A</p> Signup and view all the answers

    In a patient with cutaneous amyloidosis, what organ association is commonly seen?

    <p>Kidney</p> Signup and view all the answers

    What would be the next step for a patient suspected of systemic amyloidosis?

    <p>Blood or urine electrophoresis</p> Signup and view all the answers

    A male patient with an erythematous rash and bone pain should have a bone x-ray performed on which site if the skull or cranium is not present?

    <p>Arm</p> Signup and view all the answers

    What genetic mutation is associated with Legius syndrome, which presents without tumors, freckles, lipoma, macrocephaly, and ADHD?

    <p>SPRED1 gene</p> Signup and view all the answers

    Which gene defect is associated with Legius syndrome, presenting without tumors, freckles, lipoma, macrocephaly, and ADHD?

    <p>SPRED1</p> Signup and view all the answers

    In a case of lipoid proteinosis causing hoarseness of voice, what is the most appropriate treatment?

    <p>Steroid Acitretin</p> Signup and view all the answers

    What investigation would be most appropriate for a patient with severe itchy macular hyperpigmentation on the back (macular amyloidosis)?

    <p>Congo red</p> Signup and view all the answers

    In a patient with generalized hyperpigmentation, hepatomegaly, and diabetes, what association would be expected?

    <p>McCune-Albright syndrome by GNAS mutation</p> Signup and view all the answers

    Which investigation would be most appropriate for a 10-year-old child with normal findings but scars on knuckles, to differentiate between porphyria types?

    <p>Urine porphyrin negative blood porphyrin positive</p> Signup and view all the answers

    (Angiokeratoma) presenting with hyperkeratosis and rete ridges encircling dilated vessels in the papillary dermis points to a defect in which enzyme?

    <p>Fabry's disease enzyme</p> Signup and view all the answers

    What is the next most appropriate step for a female patient with macular amyloidosis?

    <p>Seek evaluation by an ophthalmologist.</p> Signup and view all the answers

    In a case of juvenile xanthogranuloma, what would be the next most appropriate step?

    <p>Consult with an ophthalmologist.</p> Signup and view all the answers

    For a 40-year-old female with generalized purpuric eruption and sole ulcer, what would be the most appropriate treatment?

    <p>Methotrexate.</p> Signup and view all the answers

    What should be monitored during treatment for mastocytosis aggravated by a drug?

    <p>Serum creatinine levels.</p> Signup and view all the answers

    In a patient with skin-colored papules, elastic skin on the neck, and angoid streaks on the retina, what action is most appropriate?

    <p>Introduce simvastatin.</p> Signup and view all the answers

    What is the best investigation to order for a patient with perforating disease, consistent clinical features, and renal failure?

    <p>Serum creatinine test.</p> Signup and view all the answers

    What investigation is needed for a patient with nodules on the olecranon ligament?

    <p>[X-ray of the affected area.</p> Signup and view all the answers

    What is the treatment of choice for end-stage renal disease with perforating disease?

    <p>[NBUVB phototherapy].</p> Signup and view all the answers

    A 3-month-old child presents with vomiting and brown lesions, and an X-ray shows osteolytic lesions. What is the most appropriate treatment?

    <p>Vincristine or vinblastine</p> Signup and view all the answers

    What is the most appropriate treatment for an infant with low weight and multiple brown lesions with X-ray findings of osteolytic lesions?

    <p>Vincristine</p> Signup and view all the answers

    In a patient with lipoid proteinosis causing hoarseness of voice, which treatment should be avoided due to the potential severity of adverse reactions?

    <p>Chemo Steroid + Melphalan</p> Signup and view all the answers

    In a case of generalized hyperpigmentation, hepatomegaly, and diabetes, what association would be expected?

    <p>Hemochromatosis</p> Signup and view all the answers

    What investigation is most appropriate for a 10-year-old child with normal findings but scars on knuckles?

    <p>Blood porphyrine positive</p> Signup and view all the answers

    In a case of macular amyloidosis, what investigation would be most appropriate?

    <p>Congo red</p> Signup and view all the answers

    Which gene defect is associated with Legius syndrome, presenting without tumors, freckles, lipoma, macrocephaly, and ADHD?

    <p>SPRED1 gene</p> Signup and view all the answers

    What is the next most appropriate step for a patient suspected of systemic amyloidosis?

    <p>Blood or urine electrophoresis</p> Signup and view all the answers

    What is the next most appropriate step for a female patient with macular amyloidosis?

    <p>Consult an ophthalmologist.</p> Signup and view all the answers

    In a case of Langerhans cell histiocytosis, which investigation would be needed if the skull or cranium is not present?

    <p>X-ray on the leg.</p> Signup and view all the answers

    In a patient with nodules on the olecranon ligament, what investigation would be most appropriate?

    <p>Cholesterol levels test.</p> Signup and view all the answers

    In a patient with vesicular eruption on hand, arm, and face, with no inflammatory infiltrate in the histopathology, what would be the most appropriate treatment?

    <p>Phlebotomy if porphyria cutanea tarda (PCT) is present.</p> Signup and view all the answers

    In a case of Hypothesia and hypohydrosis, which investigation would be most appropriate?

    <p>Mucinosis muco-polysaccharide test.</p> Signup and view all the answers

    In a case of scleromyxoedema with waxy papules on the face and upper back, what would be the most appropriate treatment?

    <p>Intravenous immunoglobulin (IVIG) therapy.</p> Signup and view all the answers

    In an infant with low weight and multiple brown lesions, which treatment is most appropriate if X-ray findings show osteolytic lesions?

    <p>Vincristine therapy.</p> Signup and view all the answers

    (Angiokeratoma) presenting with hyperkeratosis and rete ridges encircling dilated vessels in the papillary dermis points to a defect in which enzyme?

    <p>[Galactosidase A].</p> Signup and view all the answers

    In a pediatric patient with erythema and bone pain, histological findings of epithelioid granuloma and few lymphocytes point to a gene defect associated with which syndrome?

    <p>Defect in Fabry's disease gene (GLA galactosidase A).</p> Signup and view all the answers

    In a patient with skin-colored papules, elastic skin on the neck, and angoid streaks on retina, what action is most appropriate?

    <p>Consider biologic therapy.</p> Signup and view all the answers

    Study Notes

    Lipoid Proteinosis

    • Treatment of choice for hoarseness of voice: Voice therapy
    • Avoid corticosteroids due to potential severe adverse reactions

    Legius Syndrome

    • SPRED1 gene defect is associated with Legius syndrome without tumors, freckles, lipoma, macrocephaly, and ADHD

    Macular Amyloidosis

    • Most appropriate investigation: Skin biopsy
    • Next step for suspected systemic amyloidosis: Further investigations like echocardiogram, bone marrow biopsy, and renal function tests
    • Next step for female patients: Genetic testing for mutations in the FGA gene

    Systemic Amyloidosis

    • Next step for suspected systemic amyloidosis: Further investigations like echocardiogram, bone marrow biopsy, and renal function tests

    Pediatric Erythema & Bone Pain

    • Histological findings of epithelioid granuloma and few lymphocytes suggest Birbeck granule deficiency associated with Chediak-Higashi syndrome

    Fabry's Disease

    • Gene defect associated with Fabry's disease: α-galactosidase A deficiency

    Erythematous Rash & Bone Pain

    • Bone x-ray for a male patient with erythematous rash and bone pain should be performed on the long bones if skull or cranium is not present.

    Cutaneous Amyloidosis

    • Common organ association: Renal involvement

    Tubers Xanthoma

    • Bilateral nodules on Achilles tendon are typically associated with elevated lipid levels

    Angiokeratoma

    • Hyperkeratosis and rete ridges encircling dilated vessels in the papillary dermis point to a defect in α-galactosidase A enzyme

    Neurofibromatosis

    • Common association: Lisch nodules on the iris

    Wilson's Disease

    • Expected finding in the epidermis: Increased melanin deposition

    Porphyria

    • Treatment for a child with porphyria: Avoidance of sunlight and photoprotective measures

    Skin-Colored Papules, Elastic Skin, and Angoid Streaks

    • Action to consider: Genetic testing for Ehlers-Danlos syndrome

    Porphyria Investigation

    • A 10-year-old child with normal findings and scars on knuckles:
      • Expected positive investigation: Porphobilinogen deaminase activity
      • Expected negative investigation: Uroporphyrinogen I synthase deficiency

    Juvenile Xanthogranuloma

    • Next step: Observation and follow-up

    Generalized Purpuric Eruption and Sole Ulcer

    • Treatment: Corticosteroids

    Mastocytosis

    • Monitor liver function tests during treatment for mastocytosis to assess drug-induced liver injury.

    Perforating Disease

    • Investigation: Skin biopsy

    Nodules on the Olecranon Ligament

    • Investigation: Skin biopsy

    End-Stage Renal Disease with Perforating Disease

    • Treatment: Kidney transplantation

    3-Month-Old Child with Vomiting, Brown Lesions, and Osteolytic Lesions

    • Treatment: Bisphosphonates

    Hypothesia and Hypohydrosis

    • Investigation: Nerve conduction studies

    Scleromyxoedema

    • Treatment: Topical corticosteroids

    10-Year-Old Child with Normal Findings and Scars on Knuckles

    • Investigation: Porphobilinogen deaminase activity

    Langerhans Cell Histiocytosis

    • Investigation: Bone marrow biopsy

    Vesicular Eruption on Hand, Arm, and Face

    • Treatment: Topical corticosteroids

    Generalized Hyperpigmentation, Hepatomegaly, and Diabetes

    • Association: Hemochromatosis

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    Description

    Test your knowledge of metabolic disorders with this quiz covering lipoid proteinosis and systemic amyloidosis. Answer questions about treatment options, diagnostic procedures, and management of these conditions.

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