6 Questions
What is dyslipidemia characterized by?
Increases in total cholesterol, LDL-C, and triglyceride levels or decrease in HDL-C
What is the main component of the central core of lipoproteins?
Triglycerides and cholesterol esters
What is the role of lipoproteins in the body?
To transport lipids
What is the definition of dyslipidemia according to the World Health Organization (WHO)?
TC >200 mg/dl (>5.2 mmol/l) or TG >150 mg/dl (>1.7 mmol/l) or LDL-C >135 mg/dl (>3.5 mmol/l) or HDL-C <1.7 mmol/l
What is dyslipidemia an important modifiable risk factor for?
Atherosclerosis and cardiovascular disease (CVD)
What is the primary function of apolipoproteins in lipoproteins?
To recognize and bind to receptors
Study Notes
Definition of Dyslipidemia
- Dyslipidemia is a metabolic disease characterized by abnormalities in lipid metabolism
- It is marked by increases in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels, or a decrease in high-density lipoprotein cholesterol (HDL-C) levels
Lipoproteins and Lipid Transport
- Lipids are hydrophobic molecules transported by lipoproteins, complex particles with a central core of cholesterol esters and triglycerides
- Lipoproteins are surrounded by free cholesterol, apolipoproteins, and phospholipids
- Plasma lipoproteins include chylomicrons, chylomicron remnants, VLDL, IDL, LDL-C, HDL-C, and lipoprotein-a (Lp-a)
World Health Organization (WHO) Definition
- According to the WHO, dyslipidemia is defined as the presence of any of the following:
- TC >200 mg/dl (>5.2 mmol/l)
- TG >150 mg/dl (>1.7 mmol/l)
- LDL-C >135 mg/dl (>3.5 mmol/l)
- HDL-C >150 mg/dl (>1.7 mmol/l)
- LDL-C >130 mg/dl (>3.36 mmol/l)
Importance of Dyslipidemia
- Dyslipidemia is a modifiable risk factor for the development of atherosclerosis and cardiovascular disease (CVD)
Dyslipidemia is a metabolic disease characterized by abnormal lipid levels, increasing the risk of atherosclerosis and cardiovascular disease. Learn about its characteristics and risk factors.
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