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Dyslipidemia: Lipid Metabolism Abnormality

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Dyslipidemia: Lipid Metabolism Abnormality

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Questions and Answers

What is dyslipidemia characterized by?

Decreases in LDL-C and increases in HDL-C levels

Increases in HDL-C and triglyceride levels

Decreases in total cholesterol and triglyceride levels

Increases in total cholesterol, LDL-C, and triglyceride levels or decrease in HDL-C (correct)

What is the main component of the central core of lipoproteins?

Free cholesterol and apolipoproteins

Phospholipids and apolipoproteins

Lipoproteins and cholesterol

Triglycerides and cholesterol esters (correct)

What is the role of lipoproteins in the body?

To store lipids

To transport lipids (correct)

To break down lipids

To synthesize lipids

What is the definition of dyslipidemia according to the World Health Organization (WHO)?

TC >200 mg/dl (>5.2 mmol/l) or TG >150 mg/dl (>1.7 mmol/l) or LDL-C >135 mg/dl (>3.5 mmol/l) or HDL-C <1.7 mmol/l Signup and view all the answers

What is dyslipidemia an important modifiable risk factor for?

Atherosclerosis and cardiovascular disease (CVD) Signup and view all the answers

What is the primary function of apolipoproteins in lipoproteins?

To recognize and bind to receptors Signup and view all the answers

Study Notes

Definition of Dyslipidemia

Dyslipidemia is a metabolic disease characterized by abnormalities in lipid metabolism
It is marked by increases in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels, or a decrease in high-density lipoprotein cholesterol (HDL-C) levels

Lipoproteins and Lipid Transport

Lipids are hydrophobic molecules transported by lipoproteins, complex particles with a central core of cholesterol esters and triglycerides
Lipoproteins are surrounded by free cholesterol, apolipoproteins, and phospholipids
Plasma lipoproteins include chylomicrons, chylomicron remnants, VLDL, IDL, LDL-C, HDL-C, and lipoprotein-a (Lp-a)

World Health Organization (WHO) Definition

According to the WHO, dyslipidemia is defined as the presence of any of the following:
- TC >200 mg/dl (>5.2 mmol/l)
- TG >150 mg/dl (>1.7 mmol/l)
- LDL-C >135 mg/dl (>3.5 mmol/l)
- HDL-C >150 mg/dl (>1.7 mmol/l)
- LDL-C >130 mg/dl (>3.36 mmol/l)

Importance of Dyslipidemia

Dyslipidemia is a modifiable risk factor for the development of atherosclerosis and cardiovascular disease (CVD)

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Description

Dyslipidemia is a metabolic disease characterized by abnormal lipid levels, increasing the risk of atherosclerosis and cardiovascular disease. Learn about its characteristics and risk factors.