6 Questions
Which of the following is characteristic of dyslipidemia?
Increases in low-density lipoprotein cholesterol levels
Which lipoprotein is NOT mentioned as part of plasma lipoproteins?
Moderate-density lipoprotein (MDL)
What is the threshold for total cholesterol (TC) to be considered dyslipidemia according to the WHO?
200 mg/dl
What is the atherogenic index (AI) value above which dyslipidemia is defined according to the WHO?
5
Which of the following is NOT a characteristic of lipoproteins?
They are hydrophilic molecules.
Which of the following HDL-C levels indicates dyslipidemia in women according to the WHO?
35 mg/dl
Study Notes
Dyslipidemia: Definition and Characteristics
- A metabolic disease characterized by abnormal lipid metabolism
- Hallmarked by elevated levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG), and decreased levels of high-density lipoprotein cholesterol (HDL-C)
Lipid Transport and Metabolism
- Lipids are transported by lipoproteins, complex particles consisting of a central core of cholesterol esters and triglycerides, surrounded by free cholesterol, apolipoproteins, and phospholipids
- Plasma lipoproteins include chylomicrons, chylomicron remnants, very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and lipoprotein-a (Lp-a)
World Health Organization (WHO) Definition
- Dyslipidemia is defined as the presence of any of the following conditions:
- Total cholesterol (TC) > 200 mg/dl (> 5.2 mmol/l)
- Triglyceride (TG) > 150 mg/dl (> 1.7 mmol/l)
- Low-density lipoprotein cholesterol (LDL-C) > 135 mg/dl (> 3.5 mmol/l)
- High-density lipoprotein cholesterol (HDL-C) < 35 mg/dl (< 0.9 mmol/l in men) or < 40 mg/dl (< 1.0 mmol/l in women)
- Atherogenic index (AI) > 5
This quiz covers the basics of dyslipidemia, a metabolic disease characterized by abnormal lipid levels, and its role in cardiovascular disease. Learn about the importance of lipoproteins in lipid transport and the implications of dyslipidemia on health.
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