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Questions and Answers
Which of the following is characteristic of dyslipidemia?
Which of the following is characteristic of dyslipidemia?
- Decreases in triglyceride levels
- Decreases in total cholesterol levels
- Increases in high-density lipoprotein cholesterol levels
- Increases in low-density lipoprotein cholesterol levels (correct)
Which lipoprotein is NOT mentioned as part of plasma lipoproteins?
Which lipoprotein is NOT mentioned as part of plasma lipoproteins?
- Chylomicrons
- Very low-density lipoprotein (VLDL)
- Moderate-density lipoprotein (MDL) (correct)
- Lipoprotein-a (Lp-a)
What is the threshold for total cholesterol (TC) to be considered dyslipidemia according to the WHO?
What is the threshold for total cholesterol (TC) to be considered dyslipidemia according to the WHO?
- 250 mg/dl
- 300 mg/dl
- 200 mg/dl (correct)
- 150 mg/dl
What is the atherogenic index (AI) value above which dyslipidemia is defined according to the WHO?
What is the atherogenic index (AI) value above which dyslipidemia is defined according to the WHO?
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Which of the following is NOT a characteristic of lipoproteins?
Which of the following is NOT a characteristic of lipoproteins?
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Which of the following HDL-C levels indicates dyslipidemia in women according to the WHO?
Which of the following HDL-C levels indicates dyslipidemia in women according to the WHO?
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Study Notes
Dyslipidemia: Definition and Characteristics
- A metabolic disease characterized by abnormal lipid metabolism
- Hallmarked by elevated levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG), and decreased levels of high-density lipoprotein cholesterol (HDL-C)
Lipid Transport and Metabolism
- Lipids are transported by lipoproteins, complex particles consisting of a central core of cholesterol esters and triglycerides, surrounded by free cholesterol, apolipoproteins, and phospholipids
- Plasma lipoproteins include chylomicrons, chylomicron remnants, very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and lipoprotein-a (Lp-a)
World Health Organization (WHO) Definition
- Dyslipidemia is defined as the presence of any of the following conditions:
- Total cholesterol (TC) > 200 mg/dl (> 5.2 mmol/l)
- Triglyceride (TG) > 150 mg/dl (> 1.7 mmol/l)
- Low-density lipoprotein cholesterol (LDL-C) > 135 mg/dl (> 3.5 mmol/l)
- High-density lipoprotein cholesterol (HDL-C) < 35 mg/dl (< 0.9 mmol/l in men) or < 40 mg/dl (< 1.0 mmol/l in women)
- Atherogenic index (AI) > 5
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