Pathology : Metabolic, Nutritional, and Toxic Dz of bone and joints

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Questions and Answers

What aer the three main metabolic bone diseases?

Rickets/osteomalacia, fibrous osteodystrophy and osteoporosis

Which of the following is characterized by a failure to mineralize bone, resulting in soft bones?

  • Osteoporosis
  • Rickets/Osteomalacia (correct)
  • Fibrous osteodystrophy
  • Osteopenia

Fibrous osteodystrophy is primarily caused by:

  • Vitamin D toxicity
  • Increased parathyroid hormone (PTH) due to calcium/phosphorus imbalance (correct)
  • Estrogen deficiency
  • Disuse of limbs

Which metabolic bone disease is most commonly found in animals and involves both basal resorption and decreased bone production?

<p>Osteoporosis (C)</p> Signup and view all the answers

PTH promotes ______________________

<p>Bone resorption</p> Signup and view all the answers

1,25-dihydroxyvitamin D3 also stimulates bone resorption

<p>True (A)</p> Signup and view all the answers

Which of the following also impacts bone metabolism?

<p>Growth hormone (B), Insulin (A), Androgens (C), Thyroid hormone (D)</p> Signup and view all the answers

The most common metabolic bone disorder is ___________________

<p>Osteoporosis</p> Signup and view all the answers

Describe osteoporosis

<p>A bone disorder characterized by reduced bone mass (porous, thin and fragile bones)</p> Signup and view all the answers

What differentiates osteoporosis from osteopenia?

<p>Osteoporosis includes both decreased bone production and basal resorption with clinical signs like fractures (D)</p> Signup and view all the answers

Describe osteopenia?

<p>A bone disorder characterized by decreased bone density (often used to describe radiographic appearance)</p> Signup and view all the answers

What causes osteoporosis? (Looking for non-specific etiologies)

<p>Anything that causes a negative energy balance</p> Signup and view all the answers

Which of the following animals are commonly affected by osteoporosis due to increased metabolic demands?

<p>Laying hens and lactating cows (B), Pregnant ewes (C)</p> Signup and view all the answers

List the specific etiologies of osteoporosis

<p>Senility, nutritional factors, gastrointestinal parasitism, inflammatory bowel disease, corticosteroids and disuse</p> Signup and view all the answers

Which of the following gastrointestinal conditions can contribute to the development of osteoporosis in animals?

<p>Inflammatory bowel disease (B)</p> Signup and view all the answers

Disuse osteoporosis may occur in which of the following scenarios?

<p>A limb immobilized with a cast or splint (C)</p> Signup and view all the answers

Which of the following is not a typical cause of osteoporosis in veterinary medicine?

<p>Postmenopausal hormone changes (C)</p> Signup and view all the answers

Which of the following mineral deficiencies is not typically associated with osteoporosis in farm animals?

<p>Iron (C)</p> Signup and view all the answers

What is the hallmark pathological feature of rickets?

<p>Abnormal endochondral ossification and defective mineralization (B)</p> Signup and view all the answers

Which clinical signs are commonly seen in animals with rickets?

<p>Fractures and bone pain (A), Kyphosis and scoliosis (C)</p> Signup and view all the answers

Rickets and osteomalacia both involve:

<p>Defective mineralization of bone (C)</p> Signup and view all the answers

What distinguishes rickets from osteomalacia?

<p>Rickets affects both cartilage matrix and osteoid, while osteomalacia affects only osteoid (C)</p> Signup and view all the answers

Rickets occurs in _____________ (young/old) animals with open ___________. (Type out whole sentence)

<p>Rickets occurs in young animals with open physes</p> Signup and view all the answers

What age group is primarily affected by oseomalacia?

<p>Older animals (C)</p> Signup and view all the answers

What is the primary cause of rickets in animals?

<p>Vitamin D or phosphorus deficiency (B)</p> Signup and view all the answers

Which lesion is pathognomonic for rickets?

<p>Two white foci protruding below the physis with hemorrhage (C)</p> Signup and view all the answers

What is the underlying pathology that causes enlarged metaphyses in rickets?

<p>Accumulation of poorly mineralized osteoid (B)</p> Signup and view all the answers

What is a classic sign of rickets affecting the ribs?

<p>Rickets rosary – extremely thick cartilage at growth plates (B)</p> Signup and view all the answers

Which of the following conditions can occur with both osteomalacia and rickets?

<p>Renal failure (A), Chronic fluorosis (C)</p> Signup and view all the answers

Which species is most susceptible to rickets?

<p>Alpacas (D)</p> Signup and view all the answers

Which species require UV light or D3 supplementation because they cannot fully utilize D2?

<p>Birds and reptiles (D)</p> Signup and view all the answers

Which of the following is a cause of fibrous osteodystrophy?

<p>Complication of chronic renal failure (B), Renal secondary hyperparathyroidism (C), Nutritional secondary hyperparathyroidism (D)</p> Signup and view all the answers

What is “Big Head” or “Bran Disease” in horses a manifestation of?

<p>It’s a manifestation of Hypocalcemia in the diet. There is an increase in PTH release, which stimulates bone resorption. This leads to replacement by fibrosis = swelling.</p> Signup and view all the answers

What is a classic sign of fibrous osteodystrophy in reptiles?

<p>Bilateral swelling of the mandible and limbs (B)</p> Signup and view all the answers

What dietary issue commonly leads to metabolic bone disease in reptiles?

<p>Diets low in calcium and high in phosphorus (C)</p> Signup and view all the answers

Vitamin A toxicosis in cats (often from liver-rich diets) can lead to:

<p>Exostoses and fusion of cervical vertebrae (C)</p> Signup and view all the answers

Which of the following is a neurological consequence of vitamin A toxicity?

<p>Deafness in puppies and blindness in piglets (B)</p> Signup and view all the answers

Which species are unable to synthesize vitamin C and may develop scurvy?

<p>Guinea pigs and non-human primates (C)</p> Signup and view all the answers

What are common lesions seen in species with Vitamin C deficiency?

<p>Hemorrhagic costochondral junctions and swollen joints (A)</p> Signup and view all the answers

Animals with Vit C deficiency experience weak and thin collagen

<p>True (A)</p> Signup and view all the answers

Vitamin D toxicosis results in:

<p>Widespread soft tissue mineralization and hypercalcemia (B)</p> Signup and view all the answers

What is the most likely cause of death in animals with vitamin D toxicosis?

<p>Renal or cardiac failure due to mineralization (C)</p> Signup and view all the answers

What is growth retardation lattice?

<p>An abnormal remodeling resulting in elongated primary spongiosa</p> Signup and view all the answers

“Growth retardation lines" or a "growth lattice" near the physis may be seen in all of the following except:

<p>Vitamin A deficiency (D)</p> Signup and view all the answers

Which disease causes both growth retardation lines and enamel hypoplasia?

<p>Canine distemper virus (A)</p> Signup and view all the answers

What are the hallmark dental signs of fluorosis in herbivores?

<p>Chalky white foci, brown discoloration, and chip fractures (B)</p> Signup and view all the answers

Fluorine toxicosis is often seen in herbivores during ______________ following ingestion of ______________________ or _____________

<p>Developement; contaminate pastures; water</p> Signup and view all the answers

Gout is primarily a disorder involving the deposition of:

<p>Urates in membranes due to lack of uricase (B)</p> Signup and view all the answers

Which species are susceptible to gout due to the lack of uricase?

<p>Birds, reptiles, primates (B)</p> Signup and view all the answers

What causes articular gout in animals?

<p>Excess dietary protein or genetic defects in uric acid metabolism (C)</p> Signup and view all the answers

Visceral gout is most commonly caused by:

<p>Renal failure or extreme dehydration (C)</p> Signup and view all the answers

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