Menstrual Cycle, Ovarian Tumors, and Infertility
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Questions and Answers

Which statement about mature cystic teratomas is true?

  • Torsion is common, while cyst rupture is rare. (correct)
  • They frequently rupture during pregnancy.
  • They are always malignant.
  • They are benign tumors that generally do not undergo torsion.
  • Which tumor antigen is correctly paired with its ovarian tumor?

  • Cancer antigen 19-9 (CA19-9)—dysgerminoma
  • β-human chorionic gonadotropin—mucinous epithelial ovarian carcinoma
  • α-fetoprotein (AFP)—granulosa cell tumor
  • Lactate dehydrogenase—yolk sac tumor and embryonal cell carcinoma (correct)
  • Which clinical criterion should prompt referral to a gynecologic oncologist?

  • Presence of ascites (correct)
  • Patient's history of breast cancer (correct)
  • CA125 level of 30 U/mL
  • Patient's age under 30
  • Which of the following is NOT a side effect of aromatase inhibitors?

    <p>Increased muscle mass</p> Signup and view all the answers

    Which condition is commonly diagnosed among causes of chronic pelvic pain?

    <p>Irritable bowel syndrome</p> Signup and view all the answers

    Which patient complaints are NOT suggestive of interstitial cystitis?

    <p>Stress urinary incontinence</p> Signup and view all the answers

    What is the typical lesion diagnostic of interstitial cystitis during cystoscopy called?

    <p>Hunner ulcer</p> Signup and view all the answers

    Which statement is FALSE regarding the development of the hypothalamic–pituitary-ovarian axis in female fetuses?

    <p>GnRH pulse generator is active from birth.</p> Signup and view all the answers

    What is the most likely mechanism for urinary frequency and incomplete bladder emptying in a woman with large fibroids?

    <p>Compression of the bladder by the fibroid</p> Signup and view all the answers

    What is the initial management for a woman presenting with irregular bleeding and anemia due to uterine fibroids?

    <p>Iron supplementation and hormonal therapy</p> Signup and view all the answers

    What is the most suitable treatment for a 35-year-old woman with heavy bleeding and multiple fibroids who prefers minimally invasive options?

    <p>Uterine artery embolization</p> Signup and view all the answers

    What is the best initial management for a pregnant woman diagnosed with a large intramural fibroid during her first trimester?

    <p>Conservative observation</p> Signup and view all the answers

    Which of the following is NOT a use of magnetic resonance imaging in gynecologic malignancies?

    <p>All of the above</p> Signup and view all the answers

    Early pregnancy loss is most common in women with which condition?

    <p>Systemic lupus erythematosus with antiphospholipid antibodies</p> Signup and view all the answers

    Sonographically, endometriomas are typically described as which of the following?

    <p>Cystic with diffuse internal low-level echoes</p> Signup and view all the answers

    Mature ovarian cystic teratomas account for what approximate proportion of ovarian neoplasms?

    <p>One in five</p> Signup and view all the answers

    What is the most likely diagnosis for a woman with heavy menstrual bleeding, pelvic pressure, and a well-defined uterine wall mass?

    <p>Uterine fibroid</p> Signup and view all the answers

    For a woman with prolonged heavy periods and frequent urination due to a large submucosal fibroid, what is the best initial treatment option?

    <p>Hormonal therapy (e.g., GnRH agonists)</p> Signup and view all the answers

    In evaluating a case of infertility where a mass distorts the uterine cavity, which condition should be included in the differential diagnosis?

    <p>Submucosal uterine fibroid</p> Signup and view all the answers

    What is the most likely complication for a patient with sudden-onset pelvic pain, fever, and a tender mass, who has a history of uterine fibroids?

    <p>Degenerating fibroid</p> Signup and view all the answers

    What is the next best step to confirm the diagnosis in a woman with heavy menstrual bleeding and an irregularly enlarged uterus?

    <p>Pelvic ultrasound</p> Signup and view all the answers

    What is the most appropriate treatment option for a woman with severe menstrual pain and multiple fibroids who wishes to preserve her fertility?

    <p>Surgical myomectomy</p> Signup and view all the answers

    Which of the following presentations is most characteristic of pelvic inflammatory disease?

    <p>Tender abdominal mass with fever</p> Signup and view all the answers

    What is a common symptom associated with uterine fibroids, especially when they are submucosal?

    <p>Heavy menstrual bleeding</p> Signup and view all the answers

    What is the most appropriate management of a 4.2-cm simple right ovarian cyst in a neonate?

    <p>Observation with repeat sonography</p> Signup and view all the answers

    Which statement is true regarding polycystic ovarian syndrome (PCOS)?

    <p>It is the most common cause of chronic anovulation.</p> Signup and view all the answers

    Which of the following is NOT a component of the Rotterdam criteria for diagnosing PCOS?

    <p>Peripheral distribution of ovarian follicles on sonography</p> Signup and view all the answers

    What is the most common endocrine disorder affecting reproductive-aged women?

    <p>Polycystic ovarian syndrome</p> Signup and view all the answers

    Which hormone has higher circulating levels in first-degree male relatives of women with PCOS?

    <p>Testosterone</p> Signup and view all the answers

    In PCOS, altered GnRH pulsatility leads to what predominant change in hormone levels?

    <p>Increased levels of luteinizing hormone</p> Signup and view all the answers

    What characterizes the clinical presentation of an 18-year-old nulligravida with primary amenorrhea who has vaginal bleeding following a progesterone withdrawal test?

    <p>Polycystic ovarian syndrome</p> Signup and view all the answers

    Which of the following conditions is most likely to present with amenorrhea in a young woman?

    <p>Polycystic ovarian syndrome</p> Signup and view all the answers

    Study Notes

    Menstrual Cycle

    • Average duration: 28 days (other options include 21, 35, and 40 days)
    • Ovulation hormone: Luteinizing hormone (LH)
    • Endometrial thickening phase: Luteal phase
    • Estrogen's role: Promotes endometrial growth
    • Phase after ovulation: Luteal phase
    • Progesterone levels (no fertilization): Decrease, leading to menstruation
    • Follicle development hormone: Follicle-stimulating hormone (FSH)

    Ovarian Tumors

    • Most common benign tumor: Serous cystadenoma
    • Typical symptom: Abdominal bloating and pelvic pain
    • Imaging for ovarian tumors: Pelvic ultrasound
    • Most likely malignant tumor type: Epithelial tumors
    • Tumor marker for ovarian cancer: CA-125
    • Other tumor markers: Beta-hCG, AFP, CEA

    Infertility

    • Definition of infertility: Inability to conceive after 12 months of regular, unprotected intercourse
    • Hormone for ovarian reserve: Anti-Müllerian hormone (AMH)
    • Fallopian tube blockage test: Hysterosalpingography (HSG)
    • Infertility causes: Polycystic ovary syndrome (PCOS), endometriosis, low body weight
    • Scarring/adhesion cause: Endometriosis
    • Lifestyle factor affecting male fertility: Smoking
    • Ovulation-stimulating medication: Clomiphene citrate

    Gynecological Examination & Procedures

    • First step: Taking the patient's medical history
    • Vaginal canal/cervix exam tool: Speculum
    • Pap smear purpose: Detect cervical cell abnormalities
    • Imaging for uterus/ovaries/fallopian tubes: Ultrasound
    • Pelvic organ assessment: Bimanual examination

    Specific Clinical Cases (Page 5)

    • Severe pelvic pain during menstruation, painful intercourse, and ultrasound showing ovarian cysts: Likely diagnosis is endometriosis.
    • Chronic pelvic pain, heavy periods, and infertility issues: Likely diagnosis is endometriosis.
    • Endometriosis with increasing pain despite hormonal therapy: Laparoscopic surgery is a potential next treatment option.
    • Painful urination and rectal pain during menstruation accompanied by lower abdominal pain: Possible impacted endometrial tissue in the bladder and bowel.
    • Endometriosis, desire to maintain fertility: Conservative laparoscopic surgery might be indicated.
    • Endometriosis and persistent symptoms: GnRH agonists are a potential medication for symptom management.

    IUD Insertion

    • Optimal IUD insertion time: 4-6 days or 14-16 days of the menstrual cycle

    Acute Abdomen in Gynecology

    • Common causes: Ectopic pregnancy, endometriosis, uterine fibroids, and ovarian cysts
    • Symptom of ruptured ectopic pregnancy: Severe pelvic pain and vaginal bleeding
    • Imaging for gynecological acute abdomen: Ultrasound
    • First-line treatment for a ruptured ovarian cyst: Surgical intervention (if bleeding is severe)
    • Condition requiring emergency treatment: Ovarian torsion
    • Symptom of PID (Pelvic Inflammatory Disease): Pelvic pain, fever, and vaginal discharge
    • Risk factor for ectopic pregnancy: Previous history of PID
    • Blood test for ectopic pregnancy: Serum hCG

    Assisted Reproductive Technologies (ART)

    • ART purposes: Overcome infertility, restore fallopian tube patency, and stimulate ovulation/spermatogenesis
    • Artificial Insemination (AI): Introduction of sperm into the uterus
    • Main causes of anovulation: Hypothalamic-pituitary insufficiency, hypothalamic-pituitary dysfunction, polycystic ovaries

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    Description

    Explore the essentials of the menstrual cycle, common ovarian tumors, and the definitions and causes of infertility. This quiz covers hormone roles, tumor markers, and diagnostic procedures, providing a comprehensive overview of reproductive health topics. Test your understanding of these vital medical concepts.

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