Meningocoele and Meningomyelocoele Malformations
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Questions and Answers

Which type of spinal dysraphism is characterized by a vertebral defect with no fusion of two halves of the vertebral arch?

  • Meningocoele
  • Spina bifida occulta (correct)
  • Myelomeningocoele
  • None of the above

Which region is commonly affected by spina bifida occulta?

  • Thoracic
  • Cervical
  • Lumbar
  • Sacral (correct)

What is the main characteristic feature of spina bifida occulta?

  • Defect in the skin with a visible opening
  • Presence of a small dimple with or without hair (correct)
  • Severe neurological symptoms
  • Complete absence of any symptoms

What percentage of people does spina bifida occulta affect?

<p>10% (C)</p> Signup and view all the answers

Which type of spinal dysraphism involves a defect in the skin and may present with fluid-filled sac protruding through the vertebral defect?

<p>Myelomeningocoele (C)</p> Signup and view all the answers

What is the main difference between a meningocoele and a meningomyelocoele?

<p>In a meningocoele, only the meninges protrude through the vertebral defect, while in a meningomyelocoele, the spinal cord also extends through the defect. (C)</p> Signup and view all the answers

What type of developmental anomaly is a meningocoele?

<p>A congenital malformation of the central nervous system. (B)</p> Signup and view all the answers

Which of the following is NOT a common symptom of meningomyelocoele?

<p>Difficulty with speech and language development. (D)</p> Signup and view all the answers

What is the main reason why individuals with meningomyelocoele are at risk of infection?

<p>The thin overlying skin covering the protruding spinal cord and meninges is prone to breakdown and infection. (C)</p> Signup and view all the answers

Why are motor and sensory deficits common in individuals with meningomyelocoele?

<p>The protruding spinal cord is exposed to mechanical trauma, leading to damage and loss of function. (D)</p> Signup and view all the answers

What is the most well-established risk factor for neural tube defects (NTDs)?

<p>Folate deficiency during the first weeks of gestation (A)</p> Signup and view all the answers

What is the relationship between forebrain anomalies and mutations in several genes?

<p>Forebrain anomalies are caused by mutations in several genes required for proper cerebral development. (B)</p> Signup and view all the answers

Which of the following is TRUE about megalencephaly and microencephaly?

<p>Megalencephaly is characterized by an abnormally small brain volume. (D)</p> Signup and view all the answers

What can microencephaly be associated with?

<p>Chromosome abnormalities, fetal alcohol syndrome, and HIV-1 acquired in utero. (B)</p> Signup and view all the answers

What is the primary cause of microencephaly?

<p>Reduction in the number of neurons reaching the neocortex. (C)</p> Signup and view all the answers

Which of the following is NOT a potential cause of microencephaly mentioned in the text?

<p>Exposure to radiation during pregnancy (C)</p> Signup and view all the answers

What is the percentage of serious malformations at birth?

<p>3% (D)</p> Signup and view all the answers

Which factor is highlighted as undetermined in over 50% of malformations?

<p>Aetiology (D)</p> Signup and view all the answers

Which environmental factor is mentioned as a teratogen?

<p>Chemical agents (C)</p> Signup and view all the answers

When does a teratogenic agent produce more damage?

<p>Early in gestation (D)</p> Signup and view all the answers

Which part of the neural tube do most common defects affect?

<p>Spinal cord (A)</p> Signup and view all the answers

What do neural tube defects involve?

<p>Combination of neural tissue, meninges, and overlying bone or soft tissue (D)</p> Signup and view all the answers

What is the most severe form of forebrain malformation described?

<p>Cyclopia (A)</p> Signup and view all the answers

Which type of malformation is characterized by the complete failure of the brain to divide?

<p>Alobar (B)</p> Signup and view all the answers

What is the consequence of arhinencephaly?

<p>Absence of the olfactory bulb (C)</p> Signup and view all the answers

Which type of malformation involves fusion of cerebral hemispheres in the frontal lobes?

<p>Semi-lobar (A)</p> Signup and view all the answers

How does semi-lobar malformation differ from lobar malformation?

<p>Fusion in frontal and parietal regions (C)</p> Signup and view all the answers

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