Medications: Epoetin Chapter 11 Quiz
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Questions and Answers

What is the maximum recommended dose of acetaminophen for adults?

  • 5g
  • 4g (correct)
  • 3g
  • 2g

Which parameter should be assessed to monitor the risk of renal toxicity related to medication administration?

  • Temperature
  • Respiratory rate
  • Urinary output, BUN, creatinine (correct)
  • Blood pressure

Which action should a patient take if they experience a rash or fever after taking acetaminophen?

  • Continue taking acetaminophen at the same dose
  • Ignore it unless it persists for more than a week
  • Double the dose of acetaminophen
  • Report the rash or fever (correct)

What is the onset of action for oral administration of aspirin?

<p>15-120 minutes (D)</p> Signup and view all the answers

How should 'chewable' tablets of acetaminophen be taken?

<p>Chewed before swallowing (B)</p> Signup and view all the answers

Which medication can cross the placenta and enter breast milk according to the text?

<p>Aspirin (D)</p> Signup and view all the answers

When should blood for the aPTT be drawn with intermittent administration of heparin?

<p>1 hour before a dose of heparin is scheduled (A)</p> Signup and view all the answers

For which condition should premature infants not receive epoetin alfa from multidose vials?

<p>Anemia associated with cancer chemotherapy (B)</p> Signup and view all the answers

What is the typical onset of action for epoetin alfa?

<p>11-14 days (B)</p> Signup and view all the answers

Why is it not necessary to monitor aPTT with low-dose standard heparin given subcutaneously?

<p>The dosage is too low to affect aPTT (D)</p> Signup and view all the answers

Which group of patients may benefit from treatment with ESAs due to reduced production of erythropoietin?

<p>Patients with chronic kidney disease (D)</p> Signup and view all the answers

What is the primary clinical benefit of treating anemia with ESAs, as mentioned in the text?

<p>Enhancing overall quality of life (C)</p> Signup and view all the answers

Which hemoglobin value indicates that ESAs should be avoided in patients?

<p>12 g/dL (B)</p> Signup and view all the answers

Why is it important for patients receiving Epoetin alfa to also take an iron supplement?

<p>To ensure Epoetin alfa's effectiveness (B)</p> Signup and view all the answers

Which ESA has a relatively longer duration of action compared to epoetin alfa?

<p>Darbepoetin (B)</p> Signup and view all the answers

What is the black box warning for epoetin beta (Mircera)?

<p>Not indicated for treatment of chemotherapy-induced anemia (C)</p> Signup and view all the answers

What is the primary function of interferons in viral infections?

<p>Inhibit protein synthesis in the virus (D)</p> Signup and view all the answers

How do interferons affect viruses in infected cells?

<p><strong>Interfere</strong> with their RNA function (D)</p> Signup and view all the answers

What is the primary indication for using Epoetin?

<p>Management of anemia (B)</p> Signup and view all the answers

Which of the following medications has a duration of action of approximately 3-6 hours when administered orally?

<p>Tylenol (Acetaminophen) (C)</p> Signup and view all the answers

What is a potential side effect of Aspirin when serum drug levels exceed 300 mcg?

<p>Nephrotoxicity (B)</p> Signup and view all the answers

Which medication is classified as an opioid in the provided text?

<p>Ibuprofen (D)</p> Signup and view all the answers

What is the primary effect of Heparin on the body based on the text?

<p>Prevention of blood clots (D)</p> Signup and view all the answers

What is the primary reason for not admixing penicillins with aminoglycosides in a syringe or IV solution?

<p>Inactivation of the aminoglycoside by the penicillin (A)</p> Signup and view all the answers

What is the recommended timing for administering ampicillin in relation to meals?

<p>1 hour before or 2 hours after a meal (A)</p> Signup and view all the answers

Which drug is used to overcome resistance in bacteria that secrete beta-lactamase?

<p>Clavulanic acid (C)</p> Signup and view all the answers

What is the role of probenecid when taken concomitantly with ampicillin?

<p>It blocks renal excretion of ampicillin (B)</p> Signup and view all the answers

Which drug decreases the therapeutic effect of ampicillin by diminishing its serum concentration?

<p>Chloroquine (B)</p> Signup and view all the answers

What is the recommended action for patients to decrease gastric irritation when taking the drug mentioned in the text?

<p>Take the drug with food or liquid (B)</p> Signup and view all the answers

Which adverse effects are associated with the drug mentioned in the text?

<p>GI bleeding and hemoptysis (C)</p> Signup and view all the answers

How does the drug mentioned in the text inhibit bacterial growth?

<p>By disrupting bacterial cell wall synthesis (D)</p> Signup and view all the answers

Which organ excretes the drug mentioned in the text?

<p>Kidneys (A)</p> Signup and view all the answers

What patient education should be provided regarding the use of penicillin, as per the text?

<p>Begin penicillin 1-2 hours after a meal (D)</p> Signup and view all the answers

Which process involves the transport of drug molecules within the body and depends largely on blood circulation?

<p>Distribution (A)</p> Signup and view all the answers

Which enzyme is responsible for catalyzing the chemical reactions of oxidation, reduction, and hydrolysis in drug metabolism?

<p>CYP enzymes (A)</p> Signup and view all the answers

What is the method by which drugs are inactivated or transformed by the body?

<p>Metabolism (D)</p> Signup and view all the answers

What process can result in the need for larger doses of a rapidly metabolized drug to maintain therapeutic effects?

<p>Enzyme inhibition (D)</p> Signup and view all the answers

Which organ is primarily responsible for the excretion of drugs from the body?

<p>Kidneys (B)</p> Signup and view all the answers

Which type of drugs are usually absorbed more rapidly than oral drugs because they move directly to the bloodstream?

<p>Subcutaneous drugs (B)</p> Signup and view all the answers

What percentage of warfarin is bound to plasma proteins in the body?

<p>98% (B)</p> Signup and view all the answers

Which organ can excrete only water-soluble substances?

<p>Kidneys (D)</p> Signup and view all the answers

In what organ does the metabolism of warfarin primarily take place?

<p>Liver (D)</p> Signup and view all the answers

What is the antidote for warfarin if the International Normalized Ratio (INR) level is 5 or more and signs of bleeding are present?

<p>Vitamin K (D)</p> Signup and view all the answers

Why should ESAs be avoided in patients with hemoglobin values of 12 g/dL or above?

<p>To reduce the risk of thrombosis (D)</p> Signup and view all the answers

What is the role of iron supplementation in patients receiving Epoetin alfa?

<p>To enhance the effect of Epoetin alfa on red blood cell production (A)</p> Signup and view all the answers

How do interferons exert their antiviral effects?

<p>By inhibiting protein synthesis in infected cells (B)</p> Signup and view all the answers

What is the significance of Darbepoetin's longer duration compared to epoetin alfa?

<p>Reduced frequency of administration (B)</p> Signup and view all the answers

Why is Epoetin beta (Mircera) contraindicated for chemotherapy-induced anemia?

<p>Because it may worsen anemia in these patients (A)</p> Signup and view all the answers

What is the primary indication for using Interferon alfa 2b (Intron A) according to the text?

<p>Genital warts treatment (A)</p> Signup and view all the answers

How does Interferon alfa 2b (Intron A) impact the growth and reproduction of cells according to the text?

<p>Inhibits cell division (A)</p> Signup and view all the answers

What is a common adverse effect associated with Interferon alfa 2b (Intron A) as mentioned in the text?

<p>Flu-like symptoms (D)</p> Signup and view all the answers

How does Interferon alfa 2b (Intron A) enhance the immune system's function according to the text?

<p>By binding to specific membrane receptors and enhancing immune response (C)</p> Signup and view all the answers

What is the pharmacokinetic profile of Interferon alfa 2b (Intron A) with regards to crossing the blood–brain barrier as per the text?

<p>Does not cross the blood–brain barrier (B)</p> Signup and view all the answers

What is a potential nursing implication for patients receiving Interferon alfa 2b (Intron A) based on its excretion pathway described in the text?

<p>Monitor renal function due to primarily renal excretion (A)</p> Signup and view all the answers

How does Interferon alfa 2b (Intron A) exert its cellular activities according to the text?

<p>By binding to specific membrane receptors on cell surfaces and enhancing immune response (D)</p> Signup and view all the answers

What role does Interferon alfa 2b (Intron A) play in inhibiting angiogenesis, as described in the text?

<p>Inhibits angiogenesis (D)</p> Signup and view all the answers

What is the peak onset of action for Interferon alfa 2b (Intron A) as mentioned in the text?

<p>3 to 12 hours (D)</p> Signup and view all the answers

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