Medications: Epoetin Chapter 11 Quiz
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Questions and Answers

What is the maximum recommended dose of acetaminophen for adults?

  • 5g
  • 4g (correct)
  • 3g
  • 2g
  • Which parameter should be assessed to monitor the risk of renal toxicity related to medication administration?

  • Temperature
  • Respiratory rate
  • Urinary output, BUN, creatinine (correct)
  • Blood pressure
  • Which action should a patient take if they experience a rash or fever after taking acetaminophen?

  • Continue taking acetaminophen at the same dose
  • Ignore it unless it persists for more than a week
  • Double the dose of acetaminophen
  • Report the rash or fever (correct)
  • What is the onset of action for oral administration of aspirin?

    <p>15-120 minutes</p> Signup and view all the answers

    How should 'chewable' tablets of acetaminophen be taken?

    <p>Chewed before swallowing</p> Signup and view all the answers

    Which medication can cross the placenta and enter breast milk according to the text?

    <p>Aspirin</p> Signup and view all the answers

    When should blood for the aPTT be drawn with intermittent administration of heparin?

    <p>1 hour before a dose of heparin is scheduled</p> Signup and view all the answers

    For which condition should premature infants not receive epoetin alfa from multidose vials?

    <p>Anemia associated with cancer chemotherapy</p> Signup and view all the answers

    What is the typical onset of action for epoetin alfa?

    <p>11-14 days</p> Signup and view all the answers

    Why is it not necessary to monitor aPTT with low-dose standard heparin given subcutaneously?

    <p>The dosage is too low to affect aPTT</p> Signup and view all the answers

    Which group of patients may benefit from treatment with ESAs due to reduced production of erythropoietin?

    <p>Patients with chronic kidney disease</p> Signup and view all the answers

    What is the primary clinical benefit of treating anemia with ESAs, as mentioned in the text?

    <p>Enhancing overall quality of life</p> Signup and view all the answers

    Which hemoglobin value indicates that ESAs should be avoided in patients?

    <p>12 g/dL</p> Signup and view all the answers

    Why is it important for patients receiving Epoetin alfa to also take an iron supplement?

    <p>To ensure Epoetin alfa's effectiveness</p> Signup and view all the answers

    Which ESA has a relatively longer duration of action compared to epoetin alfa?

    <p>Darbepoetin</p> Signup and view all the answers

    What is the black box warning for epoetin beta (Mircera)?

    <p>Not indicated for treatment of chemotherapy-induced anemia</p> Signup and view all the answers

    What is the primary function of interferons in viral infections?

    <p>Inhibit protein synthesis in the virus</p> Signup and view all the answers

    How do interferons affect viruses in infected cells?

    <p><strong>Interfere</strong> with their RNA function</p> Signup and view all the answers

    What is the primary indication for using Epoetin?

    <p>Management of anemia</p> Signup and view all the answers

    Which of the following medications has a duration of action of approximately 3-6 hours when administered orally?

    <p>Tylenol (Acetaminophen)</p> Signup and view all the answers

    What is a potential side effect of Aspirin when serum drug levels exceed 300 mcg?

    <p>Nephrotoxicity</p> Signup and view all the answers

    Which medication is classified as an opioid in the provided text?

    <p>Ibuprofen</p> Signup and view all the answers

    What is the primary effect of Heparin on the body based on the text?

    <p>Prevention of blood clots</p> Signup and view all the answers

    What is the primary reason for not admixing penicillins with aminoglycosides in a syringe or IV solution?

    <p>Inactivation of the aminoglycoside by the penicillin</p> Signup and view all the answers

    What is the recommended timing for administering ampicillin in relation to meals?

    <p>1 hour before or 2 hours after a meal</p> Signup and view all the answers

    Which drug is used to overcome resistance in bacteria that secrete beta-lactamase?

    <p>Clavulanic acid</p> Signup and view all the answers

    What is the role of probenecid when taken concomitantly with ampicillin?

    <p>It blocks renal excretion of ampicillin</p> Signup and view all the answers

    Which drug decreases the therapeutic effect of ampicillin by diminishing its serum concentration?

    <p>Chloroquine</p> Signup and view all the answers

    What is the recommended action for patients to decrease gastric irritation when taking the drug mentioned in the text?

    <p>Take the drug with food or liquid</p> Signup and view all the answers

    Which adverse effects are associated with the drug mentioned in the text?

    <p>GI bleeding and hemoptysis</p> Signup and view all the answers

    How does the drug mentioned in the text inhibit bacterial growth?

    <p>By disrupting bacterial cell wall synthesis</p> Signup and view all the answers

    Which organ excretes the drug mentioned in the text?

    <p>Kidneys</p> Signup and view all the answers

    What patient education should be provided regarding the use of penicillin, as per the text?

    <p>Begin penicillin 1-2 hours after a meal</p> Signup and view all the answers

    Which process involves the transport of drug molecules within the body and depends largely on blood circulation?

    <p>Distribution</p> Signup and view all the answers

    Which enzyme is responsible for catalyzing the chemical reactions of oxidation, reduction, and hydrolysis in drug metabolism?

    <p>CYP enzymes</p> Signup and view all the answers

    What is the method by which drugs are inactivated or transformed by the body?

    <p>Metabolism</p> Signup and view all the answers

    What process can result in the need for larger doses of a rapidly metabolized drug to maintain therapeutic effects?

    <p>Enzyme inhibition</p> Signup and view all the answers

    Which organ is primarily responsible for the excretion of drugs from the body?

    <p>Kidneys</p> Signup and view all the answers

    Which type of drugs are usually absorbed more rapidly than oral drugs because they move directly to the bloodstream?

    <p>Subcutaneous drugs</p> Signup and view all the answers

    What percentage of warfarin is bound to plasma proteins in the body?

    <p>98%</p> Signup and view all the answers

    Which organ can excrete only water-soluble substances?

    <p>Kidneys</p> Signup and view all the answers

    In what organ does the metabolism of warfarin primarily take place?

    <p>Liver</p> Signup and view all the answers

    What is the antidote for warfarin if the International Normalized Ratio (INR) level is 5 or more and signs of bleeding are present?

    <p>Vitamin K</p> Signup and view all the answers

    Why should ESAs be avoided in patients with hemoglobin values of 12 g/dL or above?

    <p>To reduce the risk of thrombosis</p> Signup and view all the answers

    What is the role of iron supplementation in patients receiving Epoetin alfa?

    <p>To enhance the effect of Epoetin alfa on red blood cell production</p> Signup and view all the answers

    How do interferons exert their antiviral effects?

    <p>By inhibiting protein synthesis in infected cells</p> Signup and view all the answers

    What is the significance of Darbepoetin's longer duration compared to epoetin alfa?

    <p>Reduced frequency of administration</p> Signup and view all the answers

    Why is Epoetin beta (Mircera) contraindicated for chemotherapy-induced anemia?

    <p>Because it may worsen anemia in these patients</p> Signup and view all the answers

    What is the primary indication for using Interferon alfa 2b (Intron A) according to the text?

    <p>Genital warts treatment</p> Signup and view all the answers

    How does Interferon alfa 2b (Intron A) impact the growth and reproduction of cells according to the text?

    <p>Inhibits cell division</p> Signup and view all the answers

    What is a common adverse effect associated with Interferon alfa 2b (Intron A) as mentioned in the text?

    <p>Flu-like symptoms</p> Signup and view all the answers

    How does Interferon alfa 2b (Intron A) enhance the immune system's function according to the text?

    <p>By binding to specific membrane receptors and enhancing immune response</p> Signup and view all the answers

    What is the pharmacokinetic profile of Interferon alfa 2b (Intron A) with regards to crossing the blood–brain barrier as per the text?

    <p>Does not cross the blood–brain barrier</p> Signup and view all the answers

    What is a potential nursing implication for patients receiving Interferon alfa 2b (Intron A) based on its excretion pathway described in the text?

    <p>Monitor renal function due to primarily renal excretion</p> Signup and view all the answers

    How does Interferon alfa 2b (Intron A) exert its cellular activities according to the text?

    <p>By binding to specific membrane receptors on cell surfaces and enhancing immune response</p> Signup and view all the answers

    What role does Interferon alfa 2b (Intron A) play in inhibiting angiogenesis, as described in the text?

    <p>Inhibits angiogenesis</p> Signup and view all the answers

    What is the peak onset of action for Interferon alfa 2b (Intron A) as mentioned in the text?

    <p>3 to 12 hours</p> Signup and view all the answers

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