Medication Side Effects and Anti-TNF Therapy Quiz
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Questions and Answers

Which of the following statements about Budesonide is true?

  • It is more effective than prednisolone in producing clinical remission in IBD
  • It is a synthetic analog of hydrocortisone
  • It is released entirely in the colon (correct)
  • It has high oral bioavailability due to significant hepatic metabolism

    • What is the goal of using hydrocortisone enemas in the treatment of inflammatory bowel disease (IBD)?

  • To maintain disease remission by acting on the intestine
  • To improve quality of life by reducing fatigue and depression
  • To induce remission by suppressing inflammation
  • To prevent flare-ups by targeting specific areas of inflammation (correct)

    • Why should glucocorticoids not be used for maintaining remission in IBD?

  • They should not be used due to their risk of significant side effects increasing with prolonged use (correct)
  • They have low risk of significant side effects with prolonged use
  • They have proven efficacy in maintaining remission
  • They are more effective than immunomodulators or biologics

    • What role do glucocorticoids like hydrocortisone play in the treatment of IBD?

    <p>Suppressing inflammation to induce remission in active disease</p> Signup and view all the answers

    What is a common adverse effect associated with the long-term use of glucocorticoids in IBD treatment?

    <p>Bone marrow depression and increased risk of infections</p> Signup and view all the answers

    How does Budesonide differ from traditional corticosteroids in the treatment of IBD?

    <p>Budesonide targets specific areas of inflammation in the intestine</p> Signup and view all the answers

    Which alternative treatment for IBD involves a combination with anti-TNF therapy and has synergistic anti-inflammatory activity?

    <p>Purine Analogs</p> Signup and view all the answers

    Which of the following is a common side effect associated with glucocorticoid use in IBD treatment?

    <p>Hypertension and hyperglycemia</p> Signup and view all the answers

    What role do purine analogs play in the treatment of IBD?

    <p>They are used to reduce or eliminate the need for corticosteroids</p> Signup and view all the answers

    In cases where patients do not respond well to traditional IBD treatments, which alternative therapy might be considered?

    <p>Tofacitinib (Janus Kinase Inhibitor)</p> Signup and view all the answers

    What is the median time to clinical response with chronic administration of infliximab for moderate to severe Crohn disease?

    <p>2 weeks</p> Signup and view all the answers

    What is the main purpose of anti-integrin agents in the treatment of inflammatory bowel disease (IBD)?

    <p>Prevent influx of inflammatory cells into intestinal lesions</p> Signup and view all the answers

    Which statement about the side effects of glucocorticoids in IBD treatment is true?

    <p>They can lead to leukopenia</p> Signup and view all the answers

    What is the approved dosing regimen for infliximab in the maintenance of remission for Crohn’s disease?

    <p>Every 8 weeks</p> Signup and view all the answers

    What is the main goal of using hydrocortisone enemas in the treatment of IBD?

    <p>To reduce inflammation in the colon</p> Signup and view all the answers

    What is the FDA-approved glucocorticoid for the treatment of moderate to severe IBD?

    <p>Budesonide</p> Signup and view all the answers

    How long does it generally take for improvement to occur in most patients with Crohn’s disease after initiating glucocorticoid treatment?

    <p>5 days</p> Signup and view all the answers

    What is the preferred route of administration for active cases of IBD in the rectum and sigmoid colon?

    <p>Hydrocortisone enemas, foam, suppositories</p> Signup and view all the answers

    What are some serious side effects associated with glucocorticoids in the treatment of IBD?

    <p>Osteoporosis, hyperglycemia, gastric ulcers</p> Signup and view all the answers

    Why is maintenance treatment with systemic glucocorticoids not recommended?

    <p>Increased susceptibility to infections</p> Signup and view all the answers

    What is the mechanism of action of Vedolizumab (VDZ) in treating intestinal lesions?

    <p>Suppresses inflammatory cell recruitment selectively in the intestine</p> Signup and view all the answers

    Which therapy is considered a second-line treatment for patients with moderate to severe Crohn’s Disease who have failed other therapies?

    <p>Ustekinumab</p> Signup and view all the answers

    What is a common adverse effect associated with Vedolizumab (VDZ) treatment?

    <p>Nasopharyngitis</p> Signup and view all the answers

    Which statement is true regarding the administration of Ustekinumab?

    <p>Initial dose as IV infusion</p> Signup and view all the answers

    What is the primary goal of using anti-Integrin agents in the treatment of inflammatory bowel disease (IBD)?

    <p>Preventing leukocyte migration to intestinal lesions</p> Signup and view all the answers

    What is the mechanism of action of anti-integrin agents in the treatment of inflammatory bowel disease (IBD)?

    <p>Preventing the influx of inflammatory cells into intestinal lesions</p> Signup and view all the answers

    Which anti-IBD drug is classified as an Anti-IL-12/23 Therapy?

    <p>Ustekinumab</p> Signup and view all the answers

    What is a significant adverse effect associated with Vedolizumab (VDZ) therapy?

    <p>Hepatitis B reactivation</p> Signup and view all the answers

    Which of the following statements about Ustekinumab is true?

    <p>Has a prolonged median time to clinical response</p> Signup and view all the answers

    What potential outcome is observed when infliximab therapy is discontinued, even after prolonged remission?

    <p>High rate of disease flare</p> Signup and view all the answers

    What is the black box warning issued by the FDA in 2019 regarding Tofacitinib (Xeljanz)?

    <p>Increased risk of thrombosis, pulmonary embolism, and death with higher doses</p> Signup and view all the answers

    What is a recommended precaution before starting treatment with Tofacitinib (Xeljanz) to reduce the risk of herpes zoster reactivation?

    <p>Vaccinate with Shingrix 3-4 weeks prior to treatment</p> Signup and view all the answers

    Which interleukins involved in mucosal inflammation are influenced by interruption of the signaling pathway by certain medications?

    <p>IL-12 and IL-23</p> Signup and view all the answers

    What is a significant reason why Tofacitinib (Xeljanz) should not be taken concurrently with other immunosuppressants?

    <p>Higher risk of infections</p> Signup and view all the answers

    At what point is it recommended to discontinue Tofacitinib (Xeljanz) if there is no response observed?

    <p>By 16 weeks of treatment</p> Signup and view all the answers

    Which medication is classified as an anti-IL-12/23 therapy for the treatment of Inflammatory Bowel Disease?

    <p>Ustekinumab</p> Signup and view all the answers

    What is a potential adverse effect associated with Vedolizumab (VDZ) therapy in the treatment of IBD?

    <p>Reactivation of tuberculosis</p> Signup and view all the answers

    Which of the following medications is an Alpha-4 integrin inhibitor used in the treatment of Inflammatory Bowel Disease?

    <p>Vedolizumab</p> Signup and view all the answers

    What is one of the goals of using Anti-Integrin agents in the treatment of Inflammatory Bowel Disease?

    <p>Promoting mucosal healing</p> Signup and view all the answers

    Which biologic therapy aims for inhibition of interleukins 12 and 23 in patients with Inflammatory Bowel Disease?

    <p>Ustekinumab</p> Signup and view all the answers

    What is the main reason behind Vedolizumab (VDZ) having little systemic immunosuppression?

    <p>It acts selectively in the intestine</p> Signup and view all the answers

    Which therapy is considered a second-line treatment for moderate to severe Crohn’s Disease patients who have not responded to other treatments?

    <p>Ustekinumab</p> Signup and view all the answers

    What is a common adverse effect associated with the Ustekinumab therapy for Crohn’s Disease?

    <p>Upper respiratory infection</p> Signup and view all the answers

    How does Vedolizumab (VDZ) achieve its therapeutic effects in treating intestinal lesions?

    <p>By selectively inhibiting lymphocyte trafficking in the intestine</p> Signup and view all the answers

    Which medication acts by blocking cell signaling, cytokine production, and gene activation, resulting in the inhibition of cell-mediated responses important in inflammation of Crohn’s disease?

    <p>Ustekinumab</p> Signup and view all the answers

    Which of the following is a potential outcome when patients discontinue Vedolizumab therapy for inflammatory bowel disease?

    <p>High rate of disease flare</p> Signup and view all the answers

    What is a common adverse effect associated with the long-term use of Vedolizumab (VDZ) in the treatment of inflammatory bowel disease?

    <p>Arthralgia</p> Signup and view all the answers

    In the treatment of inflammatory bowel disease, which therapy aims to inhibit interleukins 12 and 23?

    <p>Ustekinumab</p> Signup and view all the answers

    What is one of the notable adverse effects associated with Vedolizumab therapy in the treatment of inflammatory bowel disease?

    <p>Progressive multifocal leukoencephalopathy (PML)</p> Signup and view all the answers

    Which therapy blocks the action of integrins in the treatment of inflammatory bowel disease?

    <p>Anti-Integrin Therapy</p> Signup and view all the answers

    What is the mechanism of action of Vedolizumab (VDZ) in the treatment of inflammatory bowel disease?

    <p>Interfering with α4β7 integrin-mediated leukocyte migration</p> Signup and view all the answers

    Which of the following is a common adverse effect associated with Vedolizumab (VDZ) therapy in the treatment of inflammatory bowel disease?

    <p>Anaphylaxis</p> Signup and view all the answers

    What is one of the goals of using anti-Integrin agents in the treatment of inflammatory bowel disease (IBD)?

    <p>Reducing gut-specific inflammation</p> Signup and view all the answers

    Which medication is classified as an Anti-IL-12/23 Therapy for the treatment of inflammatory bowel disease?

    <p>Ustekinumab</p> Signup and view all the answers

    What is a significant adverse effect associated with Vedolizumab (VDZ) therapy in the treatment of inflammatory bowel disease?

    <p>Opportunistic infections</p> Signup and view all the answers

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