Medical Terminology and Treatments

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Questions and Answers

What is the first-line treatment for myoclonic seizures?

  • Valproate (correct)
  • Phenyltoin
  • Acetazolamide
  • Phenobarbital

Which of the following symptoms is NOT indicative of parkinsonian syndrome?

  • Muscular rigidity
  • Postural instability
  • Classic rest tremor
  • Vision problems (correct)

Which item is part of the demographic database?

  • Current medications
  • Patient Identification Number (correct)
  • Vital signs
  • Medical history

Which of the following is NOT a type of information under the social/economic database?

<p>Sexual history (C)</p> Signup and view all the answers

What type of orders are written by physicians on forms for in-patients?

<p>Physician’s Order Sheet (C)</p> Signup and view all the answers

Which area of mental state is assessed by asking someone to spell 'WORLD' backwards?

<p>Orientation (A)</p> Signup and view all the answers

Which department does volunteer service typically belong to in a hospital?

<p>Medical Social Service (A)</p> Signup and view all the answers

Which of the following is NOT followed when writing Progress Notes using the standardized outline approach?

<p>Medication list (B)</p> Signup and view all the answers

What type of DNA replication is described when each strand serves as a template for a new complementary strand?

<p>Semiconservative replication (A)</p> Signup and view all the answers

Which drug specifically targets human topoisomerase II?

<p>Etoposide (C)</p> Signup and view all the answers

Which strand is synthesized discontinuously, with fragments copied close to the replication fork?

<p>Lagging strand (B)</p> Signup and view all the answers

Which rRNA size particle is absent in prokaryotes?

<p>40S (C)</p> Signup and view all the answers

Which nitrogenous base is not found in RNA?

<p>Thymine (A)</p> Signup and view all the answers

What components make up a ribonucleotide?

<p>All of these (A)</p> Signup and view all the answers

What is the consequence of the codon transition from UCA to UCU?

<p>Silent mutation (B)</p> Signup and view all the answers

What defines the wobble hypothesis in tRNA recognition?

<p>Wobble hypothesis (C)</p> Signup and view all the answers

Which of the following alkaloids is NOT classified under heterocyclic alkaloids?

<p>Proline (B)</p> Signup and view all the answers

Which active principle is typically NOT known to exhibit haemolytic properties?

<p>Ascorbic acid (A)</p> Signup and view all the answers

What type of compound serves as a precursor for terpenes and is formed by the condensation of isopentenyl pyrophosphate?

<p>Farnesyl pyrophosphate (B)</p> Signup and view all the answers

Which saponin type is characterized by a pentacyclic triterpenoidal aglycone?

<p>Acid saponin (C)</p> Signup and view all the answers

Which plant is the main source of Manila copal, commonly used for varnishing?

<p>Agathis alba (A)</p> Signup and view all the answers

Which of the following is NOT an active principle used as a diuretic by promoting dilation of the renal medullary blood vessel?

<p>Digitalis (C)</p> Signup and view all the answers

Which of the following acids is NOT an alkaloid?

<p>Malic acid (C)</p> Signup and view all the answers

Which of the following is NOT formed from the condensation of isopentenyl pyrophosphate?

<p>Methyl pyrophosphate (B)</p> Signup and view all the answers

What is the primary focus of pharmacognosy?

<p>Identification and classification of crude drugs (A)</p> Signup and view all the answers

Which of the following options are included in the study of Molecular Pharmacognosy?

<p>All of the above (D)</p> Signup and view all the answers

What are genetically modified organisms in the context of pharmaceuticals referred to?

<p>New generation pharmaceutical factories (A)</p> Signup and view all the answers

Which bacterium is associated with the transfer of T-DNA into plant tissue?

<p>Agrobacterium (D)</p> Signup and view all the answers

Chemical composition of crude drugs can vary due to which of the following factors?

<p>All of the above (D)</p> Signup and view all the answers

In pharmacognosy, what is primarily studied through morphological and histological features?

<p>Identification of crude drugs (D)</p> Signup and view all the answers

Which option best describes the actions of molecular pharmacognosy at the molecular level?

<p>Molecular analysis of active compounds (C)</p> Signup and view all the answers

What is one of the main challenges in the classification of crude drugs?

<p>Historical use of local substitutes (A)</p> Signup and view all the answers

What is the flour sifted from decorticated, ground seeds of Glycine soja used for?

<p>Detection of urea nitrogen in blood serum (B)</p> Signup and view all the answers

Which of the following is a primary constituent of Benne oil that acts as a synergist for pyrethrum insecticides?

<p>Sesamolin (D)</p> Signup and view all the answers

Which of the following polyunsaturated octadecanoic acids is considered essential for human nutrition?

<p>Linoleic acid (D)</p> Signup and view all the answers

What type of acid does glyceryl triacetate gradually release on the skin for antifungal activity?

<p>Undecylenic acid (C)</p> Signup and view all the answers

Which of the following acids is referred to as Vitamin F?

<p>Linoleic acid (B)</p> Signup and view all the answers

Which of the following statements about menthol is not true?

<p>It is synthesized from synthetic menthol (B)</p> Signup and view all the answers

Which of the following is an acyclic monoterpene hydrocarbon?

<p>Limonene (B)</p> Signup and view all the answers

Which polyunsaturated fatty acids are essential for human nutrition?

<p>Linoleic acid and Linolenic acid (D)</p> Signup and view all the answers

What type of glycoside is the dried root and stolons of licorice classified under?

<p>Sweet (A)</p> Signup and view all the answers

Which of the following compounds is not a cyanogenic glycoside?

<p>Arbutin (D)</p> Signup and view all the answers

Which anthraquinone derivative is an isomer of anthrone?

<p>Oxanthrone (D)</p> Signup and view all the answers

Which specific enzyme acts on the non-reducing ends of polysaccharides and produces maltose from amylose?

<p>A amylase (C)</p> Signup and view all the answers

Which statement about anthraquinone glycosides is FALSE?

<p>They act only as flavoring agents (B)</p> Signup and view all the answers

What reaction is involved in the conversion of liquid oils to semisolid fats?

<p>Hydrogenation (A)</p> Signup and view all the answers

Which of the following statements correctly describes the hydrolysis of anthraquinone glycosides?

<p>The aglycone portion can have di-, tri-, or tetrahydroxy modifications (D)</p> Signup and view all the answers

Which type of glycoside combines with frangula in the preparation of Movicol®?

<p>Acacia (D)</p> Signup and view all the answers

Flashcards

Sesamol

A natural compound found in sesame oil known for its synergistic effect with pyrethrum insecticides, enhancing their insecticidal activity.

Linoleic Acid

A polyunsaturated fatty acid, specifically an octadecanoic acid, essential for human health and often referred to as "Vitamin F."

Soybean meal

A type of flour derived from ground, decorticated soybeans. It's used in a medical test to detect urea nitrogen levels in blood.

Menthol

A natural compound found in peppermint oil, known for its cooling and soothing effects. It's often used in topical antipruritic agents.

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Myrcene

A type of acyclic monoterpene hydrocarbon. It's characterized by its distinct, citrus-like aroma.

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Acetic acid

Glyceryl triacetate acts as an antifungal agent through the gradual release of this acid on skin, maintaining a non-irritating concentration.

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Sesamolin

A substance found in the unsaponifiable fraction of Benne oil, an effective synergist that enhances the potency of pyrethrum insecticides.

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Pyrethin

A primary constituent of Benne Oil, found in the unsaponifiable fraction of the oil. It is a potent synergist for pyrethrum insecticides.

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Probing Questioning

This type of questioning encourages detailed answers, requiring the patient to elaborate on their thoughts and feelings.

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Medication Order

These are orders for in-patients, written by physicians on forms, specifying the medications to be administered.

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Social/Economic database

This type of database includes information about the patient's daily routines, cultural background, and living situation. It helps healthcare providers gain a deeper understanding of the patient's life.

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Test for Orientation, Registration, and Recall

This is a test that assesses a person's ability to think clearly and process information, by asking them to recall a list of words or a short story.

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Demographics Database

This is a part of the patient's record that documents their identification information, such as their name, date of birth, and insurance details.

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First-line treatment for Myoclonic Seizures

The first-line treatment for Myoclonic Seizures refers to the most common and effective medication for this type of seizure disorder.

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Symptoms of Parkinsonian Syndrome

These are symptoms that can be present in Parkinsonian syndrome, a condition that affects the brain and causes movement problems.

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Alprazolam

This is a specific type of benzodiazepine often used for anxiety relief. It helps calm the nervous system.

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What is Pharmacognosy?

The scientific study of the identification, classification, cultivation, and protection of natural sources of drugs, as well as the production of effective drug compounds at the molecular level.

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What is Molecular Pharmacognosy?

This branch of Pharmacognosy focuses on studying the molecular structure and activity of natural compounds and their potential use in medicine.

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What are genetically modified organisms used for in Pharmacognosy?

Genetically modified organisms are used as 'factories' to produce therapeutic molecules encoded by genes.

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How does environment affect the chemical composition of natural drugs?

The chemical composition of natural drugs can vary based on factors like when and where they were grown, and how they were stored.

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Which bacterium mediates T-DNA transfer in plants?

Agrobacterium is a bacterium that's used to transfer T-DNA into plant cells, which can induce the formation of hairy roots or crown galls.

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What is the focus of Pharmacognosy research considering genetics?

The study of the relationship between a plant's genetics, its chemical components, and its medicinal properties.

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Why is it important to properly identify natural drugs?

It's important to identify and authenticate natural medicines to ensure quality and safety.

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What is Taxonomy in the context of Pharmacognosy?

The study of how plants are classified and named based on their shared characteristics.

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Phenylalanine

A type of amino acid, a.k.a. L-phenylalanine. It's an essential amino acid, which means our body can't produce it, so we must obtain it from our diet. It's a building block for proteins and works as a precursor for other essential compounds, such as tyrosine. It's found in foods like meat, fish, eggs, dairy and soy products.

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Egconine

The basic building block of cocaine alkaloids, it's a complex molecule. It's structurally unique and essential for understanding cocaine's properties and effects.

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Geranyl pyrophosphate

A C-10 compound that is a precursor for terpenes. Terpenes are a large class of natural products found in plants, playing roles in flavors, fragrances, and their defense mechanisms. It's synthesized from isopentenyl pyrophosphate and dimethyallyl pyrophosphate.

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Manila copal

A resin commonly used for varnish. It's extracted from the Agathis alba tree and used in various applications for its protective and aesthetic properties.

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Acid saponin

This saponin glycoside has a pentacyclic triterpenoidal aglycone. It's a specific type of saponin based on its structure. It's often found in dicotyledonous plants - plants with two seed leaves.

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Diuretics

These compounds work as diuretics by promoting dilation of the renal medullary blood vessels. They help in increasing urine production, which can be helpful for various medical conditions.

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Quinine

This alkaloid, like arecoline, cocaine, colchicine, and lobeline, is classified as a heterocyclic alkaloid. It's a complex molecule with unique chemical properties and biological activities.

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A-solanin

This active principle, along with arbutin, glycyrrhizin, senegin, and tomatin, exhibits haemolytic properties. It's known to break down red blood cells, which can have both beneficial and harmful effects depending on the context.

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What type of glycoside is found in licorice?

A type of glycoside found in licorice root and stolons.

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Which compound is NOT a cyanogenic glycoside?

A cyanogenic glycoside is a glycoside that releases hydrogen cyanide upon hydrolysis. Arbutin does not release hydrogen cyanide upon hydrolysis.

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Which anthraquinone derivative is an isomer of anthrone?

Anthrone is a derivative of anthracene, a compound found in many natural products. Oxanthrone is an isomer of anthrone, meaning they have the same molecular formula but different structural arrangements.

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Which enzyme produces maltose from amylose?

B-amylase is an enzyme that breaks down polysaccharides, specifically amylose, into maltose units. It acts on the non-reducing ends of the polysaccharide chain.

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What gum is combined with frangula in Movicol®?

Movicol® is a medication used for constipation. It contains a specific gum along with frangula, an anthraquinone glycoside.

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What statement about anthraquinone glycosides is FALSE?

Anthraquinone glycosides are natural compounds used as cathartic agents, meaning they promote bowel movements. The aglycone portion of these compounds is responsible for their activity, not the glycone.

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What reaction is used to convert liquid oils to semisolid fats?

Hydrogenation is a chemical reaction that adds hydrogen atoms to a molecule. This process is used to convert liquid oils into semisolid fats, making them suitable for cooking and shortening.

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What is the chemical structure related to anthraquinone glycosides?

Anthraquinone glycosides are natural compounds used as cathartic agents, promoting bowel movements. They are derived from anthracene, a polycyclic aromatic hydrocarbon.

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Semiconservative Replication

A mode of DNA replication where each newly formed DNA molecule consists of one original strand and one newly synthesized strand. This occurs because the two strands of the DNA double helix separate, and each serves as a template for the synthesis of a new complementary strand.

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Topoisomerase II

A topoisomerase that helps prevent DNA tangling during replication. It is targeted by the chemotherapy drug etoposide, which inhibits its function and prevents DNA replication.

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Leading Strand

This strand is synthesized continuously in the direction of the replication fork. It is synthesized by DNA polymerase using the leading template strand as a guide.

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Lagging Strand

This strand is synthesized discontinuously, in short fragments (Okazaki fragments) away from the replication fork. Its synthesis requires RNA primers and is carried out by DNA polymerase.

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Point Mutation

A type of mutation that occurs when one nitrogenous base in a codon is replaced by another. This can result in a silent mutation (no change in amino acid), missense mutation (change in amino acid), or nonsense mutation (premature stop codon).

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Cystic Fibrosis

A genetic disorder caused by a deletion of three nucleotides in the CFTR gene, leading to the absence of phenylalanine at position 508 in the protein. This results in abnormal chloride transport, affecting the lungs, pancreas, and other organs.

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Wobble Hypothesis

A model explaining how a single tRNA can recognize multiple codons for the same amino acid. The first base (5') of the tRNA anticodon has more flexibility and can pair with more than one base at the third position (3') of the codon.

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Shine-Dalgarno Sequence

A sequence in prokaryotic mRNA that helps initiate protein synthesis by binding to the ribosome's small subunit.

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Study Notes

Medical Terminology and Treatments

  • First-line treatment for Myoclonic seizures: Valproate
  • Parkinsonian syndrome diagnosis: Bradykinesia plus one or more of classic rest tremor, muscular rigidity, or postural instability.
  • Hospital Orders: Physician's Order Sheet is used for inpatient orders.
  • Social/Economic Database Information: Includes daily activities, ethnic background, and living arrangements, but excludes sexual history.
  • Health Definition: Health is a state of complete physical, mental, and social well-being, not merely the absence of disease.

Mental State Testing

  • "Spell WORLD backwards" test: Assessment for language.

Hospital Departments

  • Volunteer service: Part of the Medical Social Service department.

Database Information

  • Demographic Database: Contains patient identification number, physician information, and occupation, as well as ethnic background.

Pharmaceutical Agents

  • Indirect Questioning Methods: This is not a question about particular drugs.
  • Anxiolytics: Diazepam, Lorazepam, Oxazepam, Alprazolam, and Clonazepam are examples.

Molecular Biology

  • DNA Replication: Semiconservative replication, where each new DNA molecule contains one original strand and one new strand. 
  • Topoisomerase II Target: Etoposide.
  • DNA Replication Strand Types: The lagging strand is synthesized discontinuously in short fragments. 
  • rRNA Size Particles (Prokaryotes): 23S, 5S, 16S rRNA size molecules are found in prokaryotes. 40S is not found in prokaryotes.
  • Absent RNA Base: Thymine is not present in RNA; uracil takes its place.
  • Ribonucleotide Components: Contains ribose, nitrogenous base, and phosphate.
  • Point Mutation Example: The transition from UCA to UCU could result in a silent mutation (no change in amino acid).
  • Cystic Fibrosis Cause: Deletion of three nucleotides in the coding region of a gene, leading to the loss of phenylalanine at position 508.
  • Wobble Hypothesis: The first base of the anticodon is not rigidly defined and can form nonstandard base pairs with the third base of the codon. This allows a single tRNA to recognise multiple codons.

Pharmacology

  • Antimicrobials and Mechanisms: Erythromycin binds to 50S ribosomal subunits.

Organic Chemistry

  • Cocaine Alkaloid Moiety: The basic unit is cinnamylcocaine.
  • C-10 Compound: Farnesyl pyrophosphate is a C-10 compound, precursor to terpenes.
  • Manila Copal Source: Agathis alba is likely source of Manila copal.
  • Diuretics: Bearberry is a diuretic that promotes dilation.
  • Movicol® Gum: Acacia gum is combined with frangula.
  • Anthraquinone Glycosides: Aglycones are related to anthracene structure and are generally used as cathartics. Activity is often enhanced by the aglycone without the glycone.

Food Science

  • Oil Conversion: Hydrogenation converts liquid oils to semisolid fats.
  • Benne Oil Constituents: Sesamol is an effective synergist in pyrethrum insecticides.
  • Soybean Products (Flour): Soybean meal is likely not used for detecting urea.

Natural Products

  • Cyanogenic Glycosides: Arbutin is not a cyanogenic glycoside; others listed are.
  • Anthrone Isomer: Oxanthrone is an isomer of anthrone.
  • Saponin Types: Acid saponins are a type of saponin with a pentacyclic triterpenoidal aglycone common in dicots.
  • Licorice Glycoside Type: Dried unpeeled or peeled licorice root and stolons are saponins.
  • Glyceryl Triacetate: Releases acetic acid in a non-irritating concentration.

General

  • Genetic Modification (GMOs): Bioreactors commonly use GMOs for producing goods encoded by exogenous genes.
  • Crude Drug Study: Pharmacognosy studies the classification, identification, cultivation, and protection of herbal drugs and their compounds. Molecular Pharmacognosy takes this further by studying the relationships of compounds and their effectiveness at a compound level.
  • Crude Drug Variability: Crude drug composition are influenced by growing stage, harvest time, locality, and storage conditions.
  • T-DNA Transfer: Agrobacterium is involved in transferring T-DNA.

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