Medical Signs and Symptoms Quiz

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Questions and Answers

Which of the following values indicates a state of acidosis?

  • PaO2 = 84 mmHg
  • HCO3- = 20 mEq/L (correct)
  • SaO2 = 98%
  • PaCO2 = 42 mmHg

What is the primary cause of respiratory alkalosis?

  • Chronic obstructive pulmonary disease (COPD)
  • Decreased metabolism of acids
  • Renal failure resulting in acid retention
  • Hyperventilation leading to excessive CO2 loss (correct)

What best describes the prodromal stage of disease?

  • A stage with chronic symptoms persisting over long durations
  • A stage primarily identifying infectious agents within the body
  • A stage of vague and non-specific manifestations signaling the onset of illness (correct)
  • A stage characterized by overt symptoms requiring immediate intervention

Which of the following statements about hyperplasia is true?

<p>Hormonal stimulation can induce hyperplastic changes (A)</p> Signup and view all the answers

During an episode of myocardial ischemia, what is primarily reduced?

<p>Blood flow and consequently oxygen delivery (A)</p> Signup and view all the answers

What is meant by sequelae in relation to a disease process?

<p>Expected subsequent injuries related to the ongoing disease (D)</p> Signup and view all the answers

Which of the following accurately describes the term 'morbidity'?

<p>The number of ill individuals per 100,000 population (D)</p> Signup and view all the answers

In wound healing, which stage primarily involves blood clot formation and the initial response to injury?

<p>Hemostasis (C)</p> Signup and view all the answers

What characterizes the term 'shift to the left' in a clinical context?

<p>A rise in immature neutrophils indicating an acute infection (D)</p> Signup and view all the answers

Which of the following best describes the passive process of diffusion?

<p>Natural movement of particles from an area of higher to lower concentration without energy (C)</p> Signup and view all the answers

Which of the following is NOT a common sign of left-sided heart failure?

<p>Swelling in the ankles (B)</p> Signup and view all the answers

What is a primary risk factor for heart disease associated with aging?

<p>Age above 65 (D)</p> Signup and view all the answers

What is the most common initial manifestation of an aortic aneurysm?

<p>Pulsatile mass (B)</p> Signup and view all the answers

What does a high number of bands in a blood test indicate?

<p>Acute inflammatory process (B)</p> Signup and view all the answers

Which of the following signs is indicative of pyelonephritis?

<p>Microscopic hematuria (A)</p> Signup and view all the answers

Which of the following is NOT considered a first line of defense in nonspecific immunity?

<p>Natural killer cells (B)</p> Signup and view all the answers

What role do white blood cells (WBCs) play in the immune system?

<p>Fight infection and pathogens (A)</p> Signup and view all the answers

What is a consequence of prolonged hypercortisolism in Cushing's disease?

<p>Glucose intolerance (A)</p> Signup and view all the answers

Which lymphatic organ is responsible for the maturation of T cells?

<p>Thymus (C)</p> Signup and view all the answers

Which of the following complications can arise from diabetes insipidus?

<p>Dehydration (C)</p> Signup and view all the answers

In the context of right-sided heart failure, which symptom is most likely?

<p>Chest discomfort (D)</p> Signup and view all the answers

In the context of natural immunity, which form of immunity is conferred through maternal transfer?

<p>Passive immunity (A)</p> Signup and view all the answers

What is one of the primary functions of the spleen?

<p>Sequester and destroy abnormally shaped RBCs (C)</p> Signup and view all the answers

Which of the following conditions can cause adrenal hyperactivity leading to Cushing’s syndrome?

<p>Lung cancer (C)</p> Signup and view all the answers

What is a characteristic feature of the body's vascular response to inflammation?

<p>Alteration in permeability of blood vessels (B)</p> Signup and view all the answers

What primary role do the kidneys serve in maintaining blood pressure regulation?

<p>Secrete renin (B)</p> Signup and view all the answers

Which of these statements is true regarding the nonspecific immune responses?

<p>They include inflammation and phagocytosis. (C)</p> Signup and view all the answers

Which of the following statements correctly describes hypoglycemia?

<p>It can lead to loss of consciousness (D)</p> Signup and view all the answers

What lab measurement is the best indicator of kidney function?

<p>Serum creatinine (B)</p> Signup and view all the answers

Which of the following is not a symptom of hyponatremia?

<p>Polyuria (B)</p> Signup and view all the answers

What is the normal hourly urinary output range for an adult?

<p>20-30 mL/hr (B)</p> Signup and view all the answers

What complication occurs due to untreated diabetes insipidus?

<p>Dehydration (B)</p> Signup and view all the answers

Which of the following ABG values indicates a normal PaCO2 level?

<p>35 to 45 mmHg (C)</p> Signup and view all the answers

Which condition is characterized by highly dilute urine and a lack of antidiuretic hormone (ADH)?

<p>Diabetes Insipidus (A)</p> Signup and view all the answers

What role does the thymus play in the immune system?

<p>It serves as a site for lymphocyte maturation. (D)</p> Signup and view all the answers

Which of the following is NOT a secondary lymphoid tissue?

<p>Bone marrow (D)</p> Signup and view all the answers

How does the body typically respond to high levels of acidity in the blood?

<p>By increasing the respiratory rate to expel carbon dioxide. (C)</p> Signup and view all the answers

What is the primary reason for fever development after an injury?

<p>Secretion of pyrogens by immune cells. (B)</p> Signup and view all the answers

Which type of immunity is acquired through direct exposure to the pathogen?

<p>Natural Immunity (B)</p> Signup and view all the answers

Which tissue is primarily involved in dissolving clots and clearing debris during the inflammatory response?

<p>Macrophages (A)</p> Signup and view all the answers

What is hyperplasia commonly associated with?

<p>An increase in the number of cells. (D)</p> Signup and view all the answers

Which of the following symptoms would indicate a possible infection in a wound?

<p>Formation of necrotic tissue (D)</p> Signup and view all the answers

What is the primary difference between a sign and a symptom in the context of disease assessment?

<p>A sign can be detected even if the patient is unconscious, while a symptom is only known by the patient. (D)</p> Signup and view all the answers

Which of the following accurately describes the term 'idiopathic'?

<p>A condition with uncertain etiology. (D)</p> Signup and view all the answers

What is meant by 'prognosis' in relation to disease?

<p>An estimate of the disease outcome based on various factors. (B)</p> Signup and view all the answers

What characterizes the clinical stage of disease?

<p>The disease is evident and identifiable. (D)</p> Signup and view all the answers

Which of the following best describes 'morbidity'?

<p>The ratio of ill cases per 100,000 individuals. (B)</p> Signup and view all the answers

Which stage is characterized by vague and nonspecific manifestations indicating a potential disease?

<p>Prodromal stage (A)</p> Signup and view all the answers

What is indicated by the term 'sequelae'?

<p>Subsequent injuries related to the original disease process. (C)</p> Signup and view all the answers

What does the term 'risk factors' refer to in disease occurrence?

<p>Contributions that increase the likelihood of a disease occurring. (A)</p> Signup and view all the answers

What is the role of antidiuretic hormone (ADH) released from the posterior pituitary?

<p>Conserves water by reducing urine output (D)</p> Signup and view all the answers

Which chemicals released at a wound site are responsible for signaling pain sensation?

<p>Histamine and prostaglandins (D)</p> Signup and view all the answers

What is the primary cause of fever during an infection?

<p>Endogenous pyrogens released by the body (D)</p> Signup and view all the answers

What is the significance of corticotropin-releasing hormone (CRH) during inflammation?

<p>Signals the release of cortisol from the adrenal glands (C)</p> Signup and view all the answers

What occurs as a result of endothelial injury in chronic hyperglycemia related to diabetes?

<p>Formation of foam cells and atherosclerotic plaque (C)</p> Signup and view all the answers

Which of the following is a symptom of pyelonephritis?

<p>Pain over flank and kidney (A)</p> Signup and view all the answers

Which lab test is crucial following a heart attack to detect muscle damage?

<p>Troponin test (B)</p> Signup and view all the answers

What describes the role of endothelin in response to vascular injury?

<p>Inhibits arterial vasodilation (C)</p> Signup and view all the answers

What is the role of the respiratory system during metabolic acidosis?

<p>Increase the rate of respirations to blow off CO2. (C)</p> Signup and view all the answers

In which condition would the kidneys attempt to reabsorb maximum H+ and excrete HCO3-?

<p>Respiratory alkalosis (C)</p> Signup and view all the answers

What signifies complete compensation in acid-base balance?

<p>pH is normal, but CO2 and HCO3 are abnormal. (D)</p> Signup and view all the answers

Which symptom is NOT associated with hyponatremia?

<p>Excessive thirst (D)</p> Signup and view all the answers

What can lead to hypernatremia in patients with diabetes insipidus?

<p>Dehydration due to fluid loss (A)</p> Signup and view all the answers

What defines dilutional hyponatremia?

<p>Low sodium in high blood volume (D)</p> Signup and view all the answers

How does the body compensate during respiratory acidosis?

<p>Retaining HCO3 and excreting H+. (D)</p> Signup and view all the answers

What is a common symptom associated with diabetes insipidus?

<p>Low blood pressure (A)</p> Signup and view all the answers

Which factor can significantly delay the wound healing process in elderly patients?

<p>Reduced circulation (A)</p> Signup and view all the answers

What characterizes a wound healing by primary intention?

<p>Edges are approximated with no gap (C)</p> Signup and view all the answers

Which growth factor aids in angiogenesis during the wound healing process?

<p>VEGF (C)</p> Signup and view all the answers

How long can the cicatrization (maturation) phase of wound healing take?

<p>1 to 2 years (D)</p> Signup and view all the answers

Which of the following wounds would likely heal by secondary intention?

<p>Decubitus ulcer (C)</p> Signup and view all the answers

Which process is primarily involved in remodeling collagen and fibrin during healing?

<p>Macrophage action (A)</p> Signup and view all the answers

Which type of wound closure involves the use of a drainage tube to aid healing?

<p>Tertiary intention (B)</p> Signup and view all the answers

What is one of the nutritional factors critical for wound healing?

<p>Albumin (D)</p> Signup and view all the answers

What is the primary function of the thymus in the lymphatic system?

<p>To mature T lymphocytes (B)</p> Signup and view all the answers

Which type of tissue is primarily responsible for producing white blood cells?

<p>Bone marrow (B)</p> Signup and view all the answers

Which structure is known as the 'graveyard of red blood cells'?

<p>Spleen (C)</p> Signup and view all the answers

What happens to T lymphocytes as they move toward the medulla of the thymus?

<p>They interact with other lymphoid cells to learn to distinguish self from foreign cells. (D)</p> Signup and view all the answers

During the alarm stage of stress, which hormone is released to prepare the body for action?

<p>Adrenaline (C)</p> Signup and view all the answers

Which of the following describes a function of lymph nodes?

<p>To filter and fight bacteria (D)</p> Signup and view all the answers

What condition occurs when there is extensive breakdown of red blood cells in the body?

<p>Splenomegaly (A)</p> Signup and view all the answers

Which of the following is NOT a primary lymphoid tissue?

<p>Lymph nodes (A)</p> Signup and view all the answers

What is one of the cardinal signs of inflammation?

<p>Loss of function (C)</p> Signup and view all the answers

Which lab test is primarily used to determine the presence of inflammation?

<p>C-reactive protein (CRP) (B)</p> Signup and view all the answers

Which of the following systemic responses is commonly associated with acute inflammation?

<p>Lymphadenopathy (D)</p> Signup and view all the answers

What role do leukocytes play during the inflammatory response?

<p>Remove debris and provide growth factors (D)</p> Signup and view all the answers

Which electrolytes are primarily regulated by the kidneys?

<p>Potassium and sodium (B)</p> Signup and view all the answers

Flashcards

What are complications?

Unexpected complications that arise from the disease process.

What is incidence?

The number of new cases of a disease occurring in a specific population during a given period.

What is diffusion?

A passive process where molecules move from an area of high concentration to an area of low concentration, requiring no energy.

What is hemostasis?

The initial stage of wound healing involving bleeding control.

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What is Cortisol?

A steroid hormone produced by the adrenal cortex that regulates the body's response to stress.

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Passive diffusion

A passive process where particles move from an area of high concentration to an area of low concentration. It requires no energy and can occur in air or water.

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Cyanosis

A bluish coloration of the skin and mucous membranes caused by a lack of oxygen in the blood (hypoxia).

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Hyperplasia

An increase in the number of cells. This can be a normal response to growth or injury, or it can be abnormal and lead to disease.

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Prodromal Stage

A stage of disease where symptoms are vague and non-specific. This is where people begin to feel 'not right'.

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Acidosis

A condition where the blood is too acidic (pH less than 7.35). It can cause issues with heart contractions, blood vessel function, medication response, and even lead to unconsciousness.

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Hypoglycemia

A condition where blood glucose levels are too low.

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Glomerular Filtration Rate (GFR)

A test that measures how well your kidneys are filtering waste products from your blood. It checks the rate at which fluid is filtered by both kidneys.

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Creatinine

A breakdown product of muscle that is completely excreted by the kidneys. It can be used as a marker for kidney function.

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Kidneys: Blood Filtration

One of the main roles of the kidneys is to filter blood and remove waste products.

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Diabetes Insipidus

A condition where the body doesn't produce enough antidiuretic hormone (ADH). This can lead to frequent urination and dehydration.

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Hyponatremia

Characterized by a low sodium level in the blood.

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Cardinal Signs of Inflammation

The cardinal signs of inflammation are redness, swelling, heat, and pain.

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Normal Hourly Urinary Output

The normal hourly urinary output for an adult is between 20 and 30 mL.

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What are the secondary lymphoid tissues?

Lymph nodes, spleen, tonsils, and Peyer's patches are secondary lymphoid tissues where lymphocytes interact with antigen-presenting cells (APCs) to fight off germs and foreign substances.

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What does the thymus do?

The thymus produces and matures T-cells, which are a type of immune cell.

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What is compensation in the body?

A process where one system, like the respiratory system, helps to regulate the balance of another system, like the metabolic system, after an imbalance.

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What is hyperplasia?

An increase in the number of cells, often caused by hormonal, compensatory, or pathological factors. Example: gingival hyperplasia.

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Why would a person develop a fever after injury?

The body's natural defense mechanism against infection. It involves raising body temperature to fight off pathogens.

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What is the role of a macrophage?

Macrophages are immune cells that break down clots, engulf foreign material, and contribute to wound healing by releasing growth factors.

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What is natural immunity?

The body develops antibodies after being exposed to a disease. This provides long-lasting immunity.

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What is passive immunity?

When antibodies are received from an external source, like breast milk or a serum injection. This provides temporary immunity.

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Left Ventricular Ejection Fraction (LVEF)

The volume of blood pumped out of the left ventricle with each heartbeat.

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Right Ventricular Ejection Fraction (RVEF)

The volume of blood pumped out of the right ventricle with each heartbeat.

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Right-Sided Heart Failure

A condition that occurs when the heart's right ventricle is too weak to pump blood effectively to the lungs.

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Cushing's Disease

A disorder caused by high levels of cortisol in the blood.

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Aortic Aneurysm

A bulging or weakening of the wall of an artery.

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Pyelonephritis

An infection of the kidneys, often causing pain in the flank, fever, and urinary symptoms.

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Risk Factors for Heart Disease

Factors that increase a person's chance of developing heart disease, including age, genetics, diabetes, smoking, and high blood pressure.

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Shift to the left

An increase in the number of immature neutrophils (bands) in a blood test, indicating an active infection or inflammatory process. The bone marrow is producing more immature white blood cells to fight the infection rapidly.

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Nonspecific Immunity

A general defense mechanism that protects the body from any harmful agent. It involves the first and second line of defense.

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Barriers in Nonspecific Immunity

The first line of defense in nonspecific immunity, acting as barriers against harmful agents. Examples include skin, mucus membranes, body secretions, and reflexes.

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Internal Nonspecific Responses

The second line of defense in nonspecific immunity, involving internal responses to combat harmful agents. This includes inflammation, phagocytosis, and natural killer cells.

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White Blood Cells (WBCs)

A crucial component of the immune system, responsible for fighting infections, responding to allergens, creating antibodies, and removing damaged tissue.

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Passive Immunity (from another person)

Acquired immunity from another person, without having been exposed to the specific infection. It can be through maternal transfer via placenta or breast milk, or through receiving antibodies from another person.

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Thymus

The organ responsible for producing and maturing T-cells, which are crucial for the adaptive immune system.

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Spleen

The organ that filters blood, removes old or damaged red blood cells, and is also part of the immune system.

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Erythrocyte Sedimentation Rate (ESR)

A measure of the rate at which red blood cells settle in a tube of blood over a specific time period. A higher ESR indicates inflammation.

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C-reactive Protein (CRP)

A protein produced by the liver in response to inflammation, its levels increase during inflammation.

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Cortisol

A hormone produced by the adrenal glands that regulates the body's response to stress. High levels can lead to hypertension and immunosuppression.

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Inflammation: RHELP

A sign of inflammation characterized by redness, swelling, heat, pain, and loss of function.

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Inflammatory Response

A process that involves the removal of debris and microorganisms from the injured area, followed by tissue repair. It's crucial for healing.

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What is a sign?

Something that can be measured, regardless of the patient's consciousness. Example: Blood pressure or fever.

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What is illness?

The subjective experience of having a disease, including feelings, sensations, and perceptions. Example: pain, fatigue, or nausea.

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What is pathogenesis?

The chain of events from the initial contact with a disease-causing agent to the ultimate expression of the disease. It explains how the disease process unfolds.

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What are risk factors?

The factors that increase the probability of developing a specific disease. Common examples include age, smoking, alcohol abuse, and exposure to certain substances.

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What is a prognosis?

A prediction of the likely outcome of a disease. It depends on factors like the severity of the disease, the patient's overall health, and available treatments.

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What is an epidemic?

A rapid increase in the number of new cases of a disease in a specific area.

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What is the prodromal stage?

The stage of a disease where symptoms are non-specific and vague. The person may feel unwell, but the exact nature of the illness is not yet clear.

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Angiogenesis

A process in wound healing where new blood vessels form, aiding in tissue repair and regeneration.

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Primary Intention Wound Healing

A type of wound closure where edges are approximated and re-epithelialization occurs, resulting in minimal scarring. Examples include surgical incisions.

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Scar Tissue

Fibrous tissue that replaces damaged tissue during wound healing, causing reduced function. May occur in wounds that heal by secondary intention.

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Secondary Intention Wound Healing

A type of wound closure where there is a large gap in tissue requiring granulation tissue formation and longer healing time. Examples include decubitus ulcers.

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Macrophages

Specialized cells that break down clots, clear debris, and release growth factors like TGF-β, VEGF, and MMPs, contributing to wound healing.

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Tertiary Intention Wound Healing

A wound where there is a large gap and contamination, requiring drainage and delayed closure. Often involves a combination of primary and secondary intention.

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TGF-β

A type of growth factor that stimulates the production of collagen precursor, promoting tissue repair.

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VEGF

A type of growth factor vital for angiogenesis, prompting new blood vessel formation and facilitating tissue healing.

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Granuloma

A fibrous capsule that surrounds a mass of epithelioid cells, lymphocytes, fibroblasts, and connective tissue. It isolates foreign substances the body can't easily remove.

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Thymus Location & Function

The thymus, a primary lymphoid tissue, is located in the mediastinum and is responsible for the maturation of T cells.

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T-cell Maturation in Thymus

The thymus is where immature T lymphocytes travel from the bone marrow. These lymphocytes mature and become trained to differentiate between self and foreign cells.

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Primary Lymphoid Tissues

Primary lymphoid tissues generate immune cells. These include the bone marrow, which produces all blood cells, and the thymus, which matures T cells.

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Secondary Lymphoid Tissues

Secondary lymphoid tissues are where immune cells interact with antigens and initiate an immune response. Examples include lymph nodes, spleen, tonsils, and Peyer's patches.

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Spleen Function

The spleen is a highly vascular organ responsible for filtering blood, removing old or damaged red blood cells, and storing white blood cells.

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Alarm Stage of Stress

The alarm stage of stress triggers the release of hormones like adrenaline and cortisol, preparing the body for a 'fight or flight' response.

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Sympathetic Nervous System Response to Stress

During stress, the sympathetic nervous system releases norepinephrine, causing an increase in heart rate and blood pressure.

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What is Diabetes Insipidus?

The body cannot regulate water balance due to a lack of ADH or the kidneys' inability to respond to it. This leads to excessive diluted urination and extreme thirst.

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How does the body compensate for metabolic acidosis?

The body compensates for metabolic acidosis by increasing respiratory rate to blow off CO2, making the blood less acidic.

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How does the body compensate for metabolic alkalosis?

The body compensates for metabolic alkalosis by decreasing breathing rate to retain CO2, making the blood more acidic.

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What is hyponatremia?

A condition where the blood sodium level is below 135 mEq/L. It can occur with low blood volume (hypovolemic) or high blood volume (dilutional).

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What is hypernatremia?

A condition where the blood sodium level is too high, often causing confusion, agitation, or seizures.

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How do the lungs compensate for metabolic acidosis?

The lungs compensate for metabolic acidosis by increasing the respiratory rate to blow off CO2 (a major acid).

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How do the kidneys compensate for respiratory acidosis?

The kidneys compensate for respiratory acidosis by reabsorbing HCO3 (a base) and excreting H+ (an acid) to make the blood less acidic.

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How do the kidneys compensate for respiratory alkalosis?

The kidneys compensate for respiratory alkalosis by reabsorbing maximum H+ (an acid) and excreting HCO3 (a base) to make the blood more acidic.

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Why do we feel pain from an injury?

The release of chemicals like histamine and prostaglandins at the site of injury, stimulating nerve endings and causing pain.

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What is polycythemia?

A blood disorder characterized by an excessive number of red blood cells in the body.

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What is pyelonephritis?

An infection of the kidneys, typically causing pain in the flank, blood and white blood cells in the urine.

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How does a fever develop?

Inflammation triggers the release of cytokines, which act as messengers to raise body temperature and fight infection.

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What is the role of the hypothalamus during inflammation?

In response to injury, the hypothalamus releases corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to release ACTH. This leads to the release of cortisol from the adrenal glands, playing a crucial role in the body's stress response to inflammation.

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What does an elevated white blood cell count indicate?

Elevated white blood cell count is often a sign of an inflammatory response in the body, such as an infection.

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What lab tests are conducted after a heart attack?

Elevated potassium levels, troponin tests, EKGs, and evidence of muscle damage are common tests performed following a heart attack.

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What is the common end result of various pathological mechanisms?

Endothelial injury is a common denominator in many disorders, leading to inflammation and the formation of atherosclerotic plaques.

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Study Notes

Pneumonia Signs/Symptoms

  • Cough
  • Fever
  • Shortness of breath
  • Chest pain
  • Fatigue

Diagnosis vs. Prognosis

  • Diagnosis: identifies a disease or condition
  • Prognosis: predicts the outcome of a disease, depending on factors like the patient, environment, resources, etc.

Bicarbonate (HCO3-) Normal Range

  • 22 to 26 mEq/L

Apoptosis Definition

  • Genetically programmed degenerative cell death
  • Example: ovarian apoptosis in females at age 55

Pyelonephritis Signs/Symptoms

  • Abdominal tenderness
  • Vomiting
  • Nausea
  • Chills
  • Fever
  • Dysuria
  • Urinary frequency
  • Microscopic hematuria
  • Pyuria (WBCs in urine)

Polydipsia Definition

  • Excessive thirst

Diabetes Insipidus

  • Lack of antidiuretic hormone (ADH)
  • Causes hypernatremia, dehydration, polyuria, and highly dilute urine

Parathyroid Hormone (PTH)

  • Secreted in response to hypocalcemia
  • Breaks down bone to re-establish normal calcium levels

Vitamin D and Kidneys

  • Kidneys synthesize a component of vitamin D
  • Patients with renal disease have decreased vitamin D
  • Vitamin D deficiency is related to cancers

Left Ventricular Ejection Fraction (LVEF)

  • Volume of blood pumped with each ventricular contraction
  • Lower than 40% of blood volume pumped out with each contraction indicates heart failure

Cushing's Disease/Syndrome

  • Adrenal overactivity (hyperadrenalism/hypercortisolism)
  • Caused by high cortisol levels in the blood
  • Symptoms/causes: adrenal adenoma, adrenal carcinoma, adrenal hyperplasia, tumors in the lung or other cancers, administration of oral, injected, or inhaled steroids.
  • Symptoms: osteoporosis, hypertension, immunosuppression, glucose intolerance, hyperglycemia

Cardinal Signs of Inflammation

  • Redness (Rubor)
  • Swelling (Tumor)
  • Heat (Calor)
  • Pain (Dolor)

Shift to the Left in Wound Healing

  • Increased immature neutrophils (bands)
  • Indicates an increase in newly formed neutrophils, usually implying an active infection or inflammatory process.

Nonspecific Immunity

  • First line of defense
  • Composed of barriers like skin, mucus membranes, and body secretions
  • Examples: inflammation, phagocytosis, natural killer cells

White Blood Cells (WBCs)

  • Leukocytes
  • Fight infection and pathogens
  • Respond to allergens
  • Create antibodies
  • Remove damaged tissue

Lymphatic Organs and T Cells

  • Thymus produces and matures T-cells specifically

Functions of the Spleen

  • Sequesters abnormal RBCs
  • Destroys them
  • Organ of immunity

Alarm Stage of Stress

  • Characterized by central nervous system and sympathetic nervous system stimulation
  • Examples: fight-or-flight response, release of epinephrine, cortisol, aldosterone, and antidiuretic hormone (ADH).

Polycythemia

  • Opposite of anemia
  • Overabundance of RBCs
  • Can cause blood clots
  • Causes: loss of oxygen/hypoxia

Hypoglycemia

  • Too little glucose in the blood
  • Symptoms: sweating, clammy skin, hunger, dizziness, nervousness, irritability, headache, heart palpitations, confusion, seizures, loss of consciousness.

Metabolic Alkalosis

  • Results from loss of H+ or addition of base to body fluid
  • Blood bicarbonate values (HCO3-) greater than 26
  • Artery pH greater than 7.45

Metabolic Acidosis

  • Abnormal accumulation of acids or loss of bases in the body
  • Arterial pH lower than 7.35
  • Symptoms include lactic acidosis, renal failure, diarrhea with loss of bicarbonate.

Respiratory Acidosis.

  • Lungs' inability to remove CO2
  • PCO2 level is greater than 45 mm Hg.
  • Symptoms include hypoxia, shallow/labored breathing, disorientation, and dysrhythmias
  • Intubation, mechanical ventilation may be necessary as nursing action

Kidney Function Tests

  • Glomerular filtration rate (GFR): measuring the speed of kidney filtration
  • Creatinine: a muscle breakdown product that measures kidney filtration

Hypo/Hypernatremia

  • Hyponatremia: low sodium in blood
  • Hypernatremia: high sodium in blood
  • Symptoms: Hyponatremia includes headache, lethargy, confusion, nausea, muscle cramps, spasms, apathy leading to high mortality rate
  • Hypernatremia includes oliguria, dryness, restlessness, decreased reflexes, tachycardia, and hypotension.

Benign vs Malignant Tumors

  • Benign tumors: well-differentiated, remain localized, and do not break away from the original tumor cell mass.
  • Malignant tumors: poorly differentiated, invasive, destructive, and can spread (metastasize) to distant sites.

Ketosis

  • Condition of producing excess ketones
  • Symptom often in T1DM, but not in T2DM
  • Dangerously imbalances body pH

Failure of the Immune System

  • Autoimmune disorders
  • Immunosuppression/immunocompromised
  • Increased susceptibility to diseases and infections
  • Inability to fight against pathogens, bacteria, and viruses
  • Potential for severe infections

Fetal Alcohol Syndrome (FAS)

  • Exposure to excess maternal alcohol consumption during pregnancy
  • Resulting physical and intellectual abnormalities in the infant (e.g., retarded physical growth, intellectual disabilities, cardiac defects, musculoskeletal abnormalities, and smaller size than normal)

Role of Cortisol

  • Regulates body's response to stress and danger
  • Has anti-inflammatory properties

Heart Attack Symptoms

  • Diaphoresis (sweating)
  • Dyspnea (difficulty breathing)
  • Extreme anxiety
  • Chest pain (Levine sign - fist to chest)
  • Pallor (pale appearance)
  • Retrosternal crushing chest pain radiating to the shoulder, arm, jaw, or back
  • Weak pulses

Process of Wound Healing

  • Hemostasis (initial response)
  • Inflammation (typically lasts up to five days)
  • Proliferation (weeks to build strength)
  • Wound contraction and remodeling (up to two years)

Hypertrophy

  • Increase in the size of tissues or organs, usually due to an increased workload.

Hyperplasia

  • Increase in the number of cells, potentially due to compensatory, hormonal, or pathologic reasons.

What would a patient be at risk for with Diabetes Insipidus?

  • Dehydration
  • Hypernatremia
  • Electrolyte imbalance

What Are the Cardinal Signs of Inflammation?

  • Redness (rubor)
  • Swelling (tumor)
  • Heat (calor)
  • Pain (dolor)
  • Loss of function (functio laesa)

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