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Questions and Answers
During which phase of the sexual response are cardiovascular and respiratory functions returning to their baseline levels?
During which phase of the sexual response are cardiovascular and respiratory functions returning to their baseline levels?
What physiological change is characteristic of the excitement phase of the human sexual response?
What physiological change is characteristic of the excitement phase of the human sexual response?
What is the approximate heart rate (beats/min) during the orgasm phase?
What is the approximate heart rate (beats/min) during the orgasm phase?
In the male sexual response, what process describes the movement of sperm into the urethra?
In the male sexual response, what process describes the movement of sperm into the urethra?
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What is a key difference in the resolution phase between males and females?
What is a key difference in the resolution phase between males and females?
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What percentage of infertility cases are due to male factors?
What percentage of infertility cases are due to male factors?
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Which factor directly diminishes sperm's capacity to navigate the female reproductive system?
Which factor directly diminishes sperm's capacity to navigate the female reproductive system?
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What condition represents dilated veins that can interfere with spermatogenesis in males?
What condition represents dilated veins that can interfere with spermatogenesis in males?
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What role does cervical mucus play in female fertility?
What role does cervical mucus play in female fertility?
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What is the primary concern regarding fallopian tubes in the context of female fertility?
What is the primary concern regarding fallopian tubes in the context of female fertility?
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An individual who has previously conceived but is now unable to conceive after one year of unprotected intercourse would be classified as experiencing what type of infertility?
An individual who has previously conceived but is now unable to conceive after one year of unprotected intercourse would be classified as experiencing what type of infertility?
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What is the significance of endometrial development in female fertility?
What is the significance of endometrial development in female fertility?
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What is a potential impact of leiomyomas (fibrous tumors) on female reproductive function?
What is a potential impact of leiomyomas (fibrous tumors) on female reproductive function?
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What is the clinical definition of infertility?
What is the clinical definition of infertility?
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Antibodies to male sperm contribute to altered reproductive function through which mechanism?
Antibodies to male sperm contribute to altered reproductive function through which mechanism?
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Which semen analysis result would be considered normal?
Which semen analysis result would be considered normal?
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Which of the following is an example of a uterine dysfunction that can lead to female altered reproductive function?
Which of the following is an example of a uterine dysfunction that can lead to female altered reproductive function?
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Which of the following is the most important cause of reproductive disorders?
Which of the following is the most important cause of reproductive disorders?
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Which of the following STIs is caused by a parasite/protozoa?
Which of the following STIs is caused by a parasite/protozoa?
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Which of the following provides the best protection against STIs?
Which of the following provides the best protection against STIs?
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What differentiates primary dysmenorrhoea from secondary dysmenorrhoea?
What differentiates primary dysmenorrhoea from secondary dysmenorrhoea?
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A 15-year-old female has not experienced menarche. This would be considered:
A 15-year-old female has not experienced menarche. This would be considered:
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Which of the following is an example of a parasitic STI?
Which of the following is an example of a parasitic STI?
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What characterizes secondary amenorrhoea?
What characterizes secondary amenorrhoea?
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Which diagnostic procedure involves injecting a radiopaque material into the uterus and fallopian tubes, followed by the use of a fluoroscope and radiograph?
Which diagnostic procedure involves injecting a radiopaque material into the uterus and fallopian tubes, followed by the use of a fluoroscope and radiograph?
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What is the primary mechanism by which hormonal contraceptives with a constant blood level of ovarian hormones prevent pregnancy?
What is the primary mechanism by which hormonal contraceptives with a constant blood level of ovarian hormones prevent pregnancy?
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In the context of infertility, what does laparoscopy primarily allow for?
In the context of infertility, what does laparoscopy primarily allow for?
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Progestin-only contraceptives primarily prevent pregnancy by what mechanism?
Progestin-only contraceptives primarily prevent pregnancy by what mechanism?
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What is the primary goal of postcoital contraception that uses high hormone concentrations?
What is the primary goal of postcoital contraception that uses high hormone concentrations?
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When evaluating altered reproductive function, what information can be gathered by observing cervical mucus changes?
When evaluating altered reproductive function, what information can be gathered by observing cervical mucus changes?
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Which of the following is NOT a listed factor to consider while treating altered reproductive function?
Which of the following is NOT a listed factor to consider while treating altered reproductive function?
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Which of the following contraceptive methods involves altering behaviors?
Which of the following contraceptive methods involves altering behaviors?
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What is the typical characteristic of functional cysts?
What is the typical characteristic of functional cysts?
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Which condition is characterized by the abnormal presence of endometrial tissue outside the uterus?
Which condition is characterized by the abnormal presence of endometrial tissue outside the uterus?
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What symptoms are commonly associated with leiomyomas?
What symptoms are commonly associated with leiomyomas?
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Which type of cyst develops after ovulation from granulosa cells?
Which type of cyst develops after ovulation from granulosa cells?
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What is a potential complication of endometriosis?
What is a potential complication of endometriosis?
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Flashcards
Vasocongestion
Vasocongestion
Swelling of genitals due to increased blood flow.
Myotonia
Myotonia
Muscle tension during sexual response.
Orgasm Duration
Orgasm Duration
Short, intense reaction lasting 3-15 seconds.
Male Ejaculation
Male Ejaculation
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Female Orgasmic Platform
Female Orgasmic Platform
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Refractory Period
Refractory Period
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Primary Infertility
Primary Infertility
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Varicocele
Varicocele
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Hormonal imbalance
Hormonal imbalance
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Motility impairment
Motility impairment
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Infertility
Infertility
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Semen analysis
Semen analysis
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Amenorrhea
Amenorrhea
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Cervical mucus
Cervical mucus
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Female reproduction contributions
Female reproduction contributions
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Sexual response phases
Sexual response phases
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Functional ovarian cysts
Functional ovarian cysts
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Follicular cysts
Follicular cysts
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Endometrial polyps
Endometrial polyps
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Leiomyomas
Leiomyomas
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Endometriosis
Endometriosis
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Dysmenorrhoea
Dysmenorrhoea
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Primary Amenorrhoea
Primary Amenorrhoea
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Secondary Amenorrhoea
Secondary Amenorrhoea
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Primary Dysmenorrhoea
Primary Dysmenorrhoea
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Secondary Dysmenorrhoea
Secondary Dysmenorrhoea
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Premenstrual Syndrome (PMS)
Premenstrual Syndrome (PMS)
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Sexually Transmitted Infections (STIs)
Sexually Transmitted Infections (STIs)
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Determination of ovulation
Determination of ovulation
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Hysterosalpingogram
Hysterosalpingogram
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Laparoscopy
Laparoscopy
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Sperm analysis
Sperm analysis
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Supportive counseling
Supportive counseling
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Hormonal contraception
Hormonal contraception
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Postcoital contraception
Postcoital contraception
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Progestin-only contraceptives
Progestin-only contraceptives
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Study Notes
Applied Pathophysiology: A Conceptual Approach to the Mechanisms of Disease
- This lecture material is adapted from a 2022 textbook.
- It focuses on the mechanisms of disease, specifically altered reproductive function.
- The author is Dr. Romeo Batacan Jr.
- The lecture series is titled MPAT12001 Medical Pathophysiology.
Altered Reproductive Function
- Hormonal Imbalance:
- Absence or infrequent ovulation
- Impaired oocyte development
- Motility Impairment:
- Issues with sperm or egg movement through reproductive tracts
- Pathway Obstruction:
- Adhesion or blockage in the pathway from cervix to ovary
- Problems with sperm and egg joining
- Inhospitable cervical mucus that blocks sperm
- Infections leading to adhesions
- Leiomyomas (fibrous tumors in uterus) distorting the endometrial cavity
- Immune Problems:
- Antibodies to sperm destroying them rapidly
General Manifestations of Altered Reproductive Function
- Infertility: inability to conceive
- Pain: indicative of infection, inflammation, or structural problems
- Amenorrhea: hormonal alterations affecting menstruation
Male Contribution to Pregnancy
- Men need sufficient sperm quantity and motility
- Semen analysis assesses:
- Volume (2-5 mL)
- Sperm density (15-39 million/mL)
- Motility (>32% good/progressive)
- Viability (>58% alive)
- Morphology (>4% normally shaped)
- Viscosity (full liquefaction within 20 minutes)
Female Contribution to Pregnancy
- Female contribution is complex and requires:
- Production of mature ovum
- Cervical mucus for sperm transport/viability
- Patent fallopian tubes for ovum transfer
- Endometrium suitable for implantation and fetal growth.
- Vagina without obstructions or malformations
Sexual Response Physiology
- Four Phases:
- Excitement: Vasocongestion, myotonia, increased heart rate, gland secretions
- Plateau: Variables sustained or slightly increase, with vasocongestion and myotonia possible increase
- Orgasm/Climax: Short, intense reaction (3-15 sec), heart rate increase( ~180 bpm), male ejaculation (emission of sperm into urethra & expulsion), female orgasmic platform contractions, cervix plunges rhythmically into vagina
- Resolution: cardiovascular and respiratory functions return to normal. Male-refractory period; Female-multiple orgasms possible.
Infertility
- Inability to conceive after a year of unprotected intercourse
- Causes are almost equally divided between:
- Male factors (30-40%)
- Female factors (30-40%)
- Combined factors (30-40%)
- ~10% to 25% of infertile couples have an unknown cause.
- Common causes include: Infections, inflammation, endocrine disorders, autoantibodies to sperm, environmental and lifestyle factors.
Male Altered Reproductive Function
-
Causes: Varicocele (10-15% of males), hormonal issues (hyper/hypogonadism) infection/immune probs (antisperm antibodies), obstruction and congenital anomalies, ejaculatory dysfunction
-
Treatment: depends on the cause; surgery, medication, artificial insemination (with donor sperm)
Female Altered Reproductive Function
- Causes of female infertility can be located in the following areas:Hypothalamus-pituitary, Ovaries, Fallopian tubes, Uterus, and Vagina. Numerous factors can contribute to each anatomical locations difficulties in the reproductive process.
Sexually Transmitted Infections (STIs)
- Single most important cause of reproductive disorders in many situations
- Reporting not mandatory for all types, but in Australia there are approximately 70,000 reported cases per year
- Transmission preventable with barrier contraception (latex condoms, female femidoms)
- Treatment effectiveness differs in ease or difficulty.
Hormonal and Menstrual Alterations
- Dysmenorrhea: Primary -ovulatory cycle related painful menstruation, Secondary- related to pelvic pathology
- Amenorrhea: Primary-absence of menstruation by age 14 (or 16), Secondary- Absence of menstruation for 3+ cycles or 6 months in menstruating women.
- Premenstrual Syndrome (PMS): Distressing symptoms in the luteal phase of women's menstrual cycles. Symptoms range from physical discomfort, emotional distress, and behavioral changes.
Detecting Altered Reproductive Function
- History and physical examination
- Sperm analysis
- Ovulation determination (cervical mucus/basal body temp/LH surge)
- Lab hormone levels, antibody detection
- Reproductive structures patency (hysterosalpingogram)
- Laparoscopy
- Genetic testing
Treating Altered Reproductive Function
- Dependent on the underlying cause.
- Supportive counseling and education
- Treatment options vary depending on the cause of problem, including infection, hormone imbalance, motility problems, and immune system problems.
Assisted Reproductive Technology (ART)
- Surgical removal of oocytes.
- Fertilization of oocytes
- Return of fertilized oocytes to the woman's body (in vitro fertilization)
- In vitro fertilization (IVF) is an expensive and sometimes painful procedure dealing with oocytes, hormones, and embryos.
Contraception
- Behavioral (rhythm method, abstinence) and barrier methods (condoms, diaphragms) along with hormonal methods to prevent pregnancy. Methods of hormonal contraception include:
- Using constant blood levels of ovarian hormones or
- Tricking the hypothalamic-pituitary axis
- Using high hormone concentrations or
- Interfering with normal hormone signals
- Preventing fertilization or
- Using progestin only methods like thickening cervical mucus, decreasing ovulation frequency, creating inhospitable endometrium etc.
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Description
Explore the mechanisms of disease related to altered reproductive function in this quiz based on Dr. Romeo Batacan Jr.'s lecture series. You'll learn about hormonal imbalances, motility impairments, pathway obstructions, and immune problems affecting reproductive health. Test your understanding of these key concepts in medical pathophysiology.