Medical Important Viruses Overview

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Questions and Answers

Which viruses are human pathogens that belong to the category of coronaviruses?

  • Rabies virus and Ebola virus
  • Parainfluenza and respiratory syncytial virus
  • SARS-Cov-2 and MERS (correct)
  • Measles and mumps

What characteristic shape do rhabdoviruses have?

  • Sphere-shaped
  • Cylindrical
  • Bullet-shaped (correct)
  • Thread-like

Which disease is associated with the SARS-Cov virus family?

  • Tuberculosis
  • Influenza
  • Common cold
  • Severe acute respiratory syndrome (SARS) (correct)

What type of RNA do filoviruses contain?

<p>Single-stranded linear negative-polarity RNA (A)</p> Signup and view all the answers

Which pathogen is primarily considered a rhabdovirus?

<p>Rabies virus (D)</p> Signup and view all the answers

Which of the following is NOT a human pathogen represented in the content?

<p>HIV virus (A)</p> Signup and view all the answers

What was the approximate fatality rate of SARS during its outbreak?

<p>9% (B)</p> Signup and view all the answers

What two primary components constitute a virus?

<p>Genome and capsid (A)</p> Signup and view all the answers

Which size range applies to most viruses compared to the cells they infect?

<p>100-1000 times smaller (C)</p> Signup and view all the answers

What is the natural reservoir for the CoV-SARS?

<p>Horseshoe bat (C)</p> Signup and view all the answers

What is a complete virus particle called?

<p>Virion (C)</p> Signup and view all the answers

Which characteristic is NOT used to classify virus families?

<p>Shape of bacterial cells infected (C)</p> Signup and view all the answers

How do virions typically protect their genetic material?

<p>Through a protein-containing lipid bilayer (B)</p> Signup and view all the answers

What is the significance of a virus's size concerning filtration?

<p>Viruses generally pass through filters designed to trap bacteria. (D)</p> Signup and view all the answers

Which type of symmetry can a virus capsid exhibit?

<p>Helical or icosahedral (A)</p> Signup and view all the answers

What indicates the pathogenicity of a virus?

<p>The variety of its structural and functional characteristics (C)</p> Signup and view all the answers

What type of genetic material do adenoviruses contain?

<p>Double-stranded linear DNA (B)</p> Signup and view all the answers

Which family of viruses is known for causing latent infections?

<p>Herpesviruses (C)</p> Signup and view all the answers

What characteristic distinguishes hepadnaviruses from other virus families?

<p>They have a double-stranded circular DNA that is not a complete circle (C)</p> Signup and view all the answers

Which virus is known to be used in the smallpox vaccine?

<p>Vaccinia virus (C)</p> Signup and view all the answers

What is the diameter of picornaviruses?

<p>28 nm (B)</p> Signup and view all the answers

Which of the following viruses can be classified as a member of the calicivirus family?

<p>Hepatitis A virus (B)</p> Signup and view all the answers

Which family of viruses is characterized by being the largest and having a complex capsid symmetry?

<p>Poxviruses (B)</p> Signup and view all the answers

What is unique about the DNA structure found in Hepadnaviruses?

<p>The complete strand is not a covalently closed circle. (A)</p> Signup and view all the answers

What forms the basis for division into genera and species within a virus family?

<p>Host range and amino acid sequences (A)</p> Signup and view all the answers

Which type of viral genome cannot be directly used as a template for protein synthesis?

<p>Negative-strand RNA (B)</p> Signup and view all the answers

What type of symmetry characterizes the capsids of viruses with multiple different polypeptides?

<p>Icosahedral symmetry (D)</p> Signup and view all the answers

In helical symmetry, what component is hydrogen-bonded to neighboring protomers?

<p>Protomer units (D)</p> Signup and view all the answers

How is the nucleic acid genome positioned in an icosahedral capsid structure?

<p>Within the capsid's rigid structure (A)</p> Signup and view all the answers

What are the most common forms of viral genomes found in nature?

<p>Single-stranded RNA and double-stranded DNA (C)</p> Signup and view all the answers

What is a significant characteristic of positive-strand RNA viruses?

<p>They can serve as a template for protein synthesis. (B)</p> Signup and view all the answers

What structural components do helical capsids rely on for their formation?

<p>Single polypeptide species (C)</p> Signup and view all the answers

What is the primary mode of transmission for MERS coronavirus (MERS-CoV) to humans?

<p>Close contact with camels (B)</p> Signup and view all the answers

In what year was COVID-19 first identified?

<p>2019 (C)</p> Signup and view all the answers

What percentage of people recovering from COVID-19 do not require special treatment?

<p>80% (C)</p> Signup and view all the answers

Which virus strain causes COVID-19?

<p>SARS-CoV-2 (C)</p> Signup and view all the answers

What is a common symptom of COVID-19?

<p>Dry cough (C)</p> Signup and view all the answers

According to the data, what is the incubation period for COVID-19?

<p>1-14 days (A)</p> Signup and view all the answers

What proportion of COVID-19 patients may develop severe illness?

<p>Around 16% (D)</p> Signup and view all the answers

Which of the following conditions increases the risk of developing serious illness from COVID-19?

<p>High blood pressure (D)</p> Signup and view all the answers

Which of the following vaccines utilizes mRNA technology?

<p>Pfizer-BioNTech COVID-19 vaccine (C)</p> Signup and view all the answers

What type of virus is the Johnson & Johnson vaccine based on?

<p>Viral vector (D)</p> Signup and view all the answers

Which type of RNA virus has double-stranded RNA as part of its structure?

<p>Reoviruses (A)</p> Signup and view all the answers

Which viral family contains single-stranded DNA viruses?

<p>Parvoviruses (A)</p> Signup and view all the answers

What classification system is primarily used to categorize viruses?

<p>Nature of the genome and envelope status (B)</p> Signup and view all the answers

Which vaccine is categorized as a protein-based vaccine?

<p>Novavax vaccine (B)</p> Signup and view all the answers

Which of the following RNA viruses have positive-polarity RNA?

<p>Caliciviruses (C)</p> Signup and view all the answers

Which type of viruses are classified as naked nucleocapsid viruses?

<p>Picornaviruses (A)</p> Signup and view all the answers

Flashcards

Viral Genome

The genetic material of a virus, which can be either RNA or DNA, and may be single-stranded (ss) or double-stranded (ds).

Positive-Strand RNA

A type of viral genome that can be directly translated into proteins.

Negative-Strand RNA

A type of viral genome that is complementary to messenger RNA and cannot be directly translated.

Capsid

The protein shell that encloses the viral genome.

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Helical Capsids

A type of capsid structure that resembles a long, coiled rod or cylinder.

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Icosahedral Capsids

A type of capsid structure that is spherical and symmetrical with 20 sides.

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Capsomers

Smaller subassemblies that form an icosahedral capsid.

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Nucleocapsid

The complex of protomers (protein units) and nucleic acid in a helical capsid.

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What is a virus?

A virus is a tiny infectious particle made up of two main parts: its genetic material (either RNA or DNA) and a protective protein coat called a capsid. They are obligate intracellular parasites, meaning they need a living host cell to multiply.

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What is a virion?

A virion is the complete, infectious form of a virus particle. It consists of the viral genome encased in a protective capsid and sometimes an outer envelope.

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What is a capsid?

The capsid is a protein shell that encloses and protects the viral genome. It's like a protective case around the virus's DNA or RNA.

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What is an envelope?

Some viruses have an additional outer layer called an envelope. This is a lipid membrane that surrounds the capsid and helps the virus enter and exit host cells.

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How are viruses classified?

Viruses are remarkably diverse. They are classified into different groups based on their genetic material (DNA or RNA), replication strategies, capsid symmetry (helical or icosahedral), and presence or absence of an envelope.

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How do viruses compare in size to their host cells?

Viruses are much smaller than the cells they infect. They can pass through filters designed to trap bacteria, which helps scientists identify them.

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What factors influence a virus's ability to cause disease?

A virus's ability to cause disease (pathogenicity) depends on many factors, including its structure, replication strategy, and interaction with the host. Even closely related viruses can cause different diseases.

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How do viruses replicate?

Viruses depend on living cells to multiply. They can't replicate on their own and need to hijack a host cell's machinery to make more copies of themselves.

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Hepadnaviruses

These viruses are distinguished by their unique double-stranded DNA structure, which is not completely circular, and their ability to cause infections that can become latent.

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Coronaviruses

A family of viruses known for causing respiratory infections, including the common cold, SARS, and COVID-19.

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SARS (Severe Acute Respiratory Syndrome)

A severe respiratory illness caused by a type of coronavirus, distinguished by an atypical pneumonia.

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Poxviruses

These viruses are characterized by their large size, brick-like shape, and complex capsid symmetry. They are known for causing skin lesions or "pocks," as their name suggests.

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SARS-CoV-2

A type of coronavirus responsible for the COVID-19 pandemic.

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Picornaviruses

These viruses are small and have a naked icosahedral capsid. Their genetic material is single-stranded, linear, nonsegmented, positive-polarity RNA. They cause infections that can be caused by either enteroviruses or rhinoviruses.

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COVID-19

A respiratory illness caused by the SARS-CoV-2 virus, characterized by fever, cough, and difficulty breathing.

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Picornaviruses

This family of viruses includes the smallest RNA viruses, with a naked icosahedral capsid. Their genome is single-stranded, linear, nonsegmented, positive-polarity RNA.

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Caliciviruses

These viruses are naked and have an icosahedral capsid. They have single-stranded, linear, nonsegmented, positive-polarity RNA.

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MERS (Middle East Respiratory Syndrome)

A severe respiratory illness caused by a different type of coronavirus, emerging in 2012.

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Rhabdoviruses

A family of bullet-shaped viruses with a helical nucleocapsid and single-stranded RNA.

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Herpesviruses

These viruses have an icosahedral nucleocapsid covered by an envelope, a double-stranded circle DNA with a unique structure. They are known for causing latent infections.

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Adenoviruses

These viruses are known for their naked icosahedral structure and double-stranded linear DNA. They are responsible for various infections, including pharyngitis and respiratory illnesses. Some types can cause sarcomas in animals, but not in humans.

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Filoviruses

A family of long, filamentous viruses with a helical nucleocapsid and single-stranded RNA.

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Positive-Polarity RNA

The type of RNA found in coronaviruses, which is directly translated into proteins.

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Poxviruses

These viruses are characterized by their large size, envelope with an unusual appearance, and complex capsid symmetry. They are known for causing skin lesions or "pocks."

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Viral Classification

Viruses can be classified based on their genome type (DNA or RNA) and their structure (presence or absence of an envelope).

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Enveloped DNA Viruses

These viruses possess a DNA genome surrounded by a membrane-like envelope.

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Naked DNA Viruses

These viruses lack an envelope and their DNA genome is protected only by a protein coat called a capsid.

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Enveloped RNA Viruses

These viruses have an RNA genome enclosed within an envelope.

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Naked RNA Viruses

These viruses lack an envelope and their RNA genome is enclosed only by a capsid.

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Segmented RNA

Some viruses have a segmented genome where their genetic material is split into multiple pieces.

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Negative-Polarity RNA

A genome that requires an intermediate step of transcription to be translated into proteins.

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What is MERS?

A respiratory illness caused by a new coronavirus, first discovered in Saudi Arabia in 2012, with camels being the suspected source of transmission.

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What is COVID-19?

An infectious disease caused by a new coronavirus, first identified in Wuhan, China in 2019, and declared a pandemic in 2020.

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What is SARS-CoV-2?

The virus that causes COVID-19. It is a type of severe acute respiratory syndrome coronavirus.

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What is the incubation period for COVID-19?

The time between exposure to a virus and the onset of symptoms. In the case of COVID-19, it can range from 1 to 14 days.

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What are the common symptoms of COVID-19?

The most common symptoms of COVID-19 are fever, tiredness, and a dry cough. Other symptoms may include aches and pains, nasal congestion, runny nose, sore throat, or diarrhea.

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What are severe symptoms of COVID-19?

In around 16% of cases, COVID-19 can lead to serious illness with difficulty breathing. Individuals at higher risk of severe complications include elderly people and those with underlying medical conditions.

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When should you seek medical attention for COVID-19?

People with fever, cough, and difficulty breathing should seek medical attention to receive proper care and treatment.

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How is MERS transmitted?

While person-to-person transmission can occur, the primary mode of transmission from animals to humans is through close contact with camels.

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Study Notes

Medical Important Viruses

  • Viruses are infectious agents,
  • Constructed of two components:
    • A genome (RNA or DNA, but not both)
    • A protein-containing structure (capsid) to protect the genome.
  • Some viruses have an additional lipid-containing envelope.
  • A complete virus particle is a virion.
  • Viruses replicate inside host cells.
  • Viral replication is a process that is obligately intracellular.

Virus Structure

  • Viruses are much smaller than cells (100-1000 times smaller).
  • Smallest viruses are 20nm in diameter, while the largest are ~300nm.
  • Viruses can pass through filters that trap bacteria.

Virus Classification

  • Viruses are categorized into families, subfamilies, genera, and species.
  • Classification is based on several factors: genome type and structure, replication strategy, capsid shape (helical or icosahedral), and presence or absence of lipid envelope.

Viral Genomes

  • Viral genomes can be DNA or RNA, either single-stranded (ss) or double-stranded (ds).
  • Common forms in nature are ssRNA and dsDNA.
  • Single-stranded RNA genomes are further classified based on polarity
    • Positive-polarity RNA genomes are similar in sequence to mRNA, and can be directly used as templates for protein synthesis.
    • Negative-polarity RNA genomes are complementary to mRNA, and need to be transcribed into positive-polarity RNA before being translated into proteins.

Viral Capsid Symmetry

  • Most virus capsids are either helical or icosahedral in shape.
  • Helical capsids are rod-shaped or coiled.
  • Icosahedral capsids are spherical or symmetric.
  • Capsids are constructed from multiple copies of a single or several polypeptide subtypes.

Viral Envelopes

  • Some viruses have an envelope, a lipid membrane surrounding the nucleocapsid.
  • Envelopes are derived from the host cell membrane.
  • Enveloped viruses are generally more sensitive to environmental factors than non-enveloped viruses.

Viral Replication

  • Viruses replicate using a series of steps, beginning with attachment to a host cell, followed by penetration and uncoating of the viral genome.
  • Gene expression and replication occur, with the assembly of viral progeny, and finally, release of viral progeny from the cell.

Baltimore Classification

  • Viruses are classified into seven groups based on their genome characteristics.
    • I: dsDNA
    • II: ssDNA
    • III: dsRNA
    • IV: (+)ssRNA
    • V: (−)ssRNA
    • VI: (+)-ssRNA-RT
    • VII: dsDNA-RT

Types of DNA Viruses

  • Naked icosahedral: parvoviruses, papovaviruses, and adenoviruses are examples of naked icosahedral DNA viruses.
  • Enveloped icosahedral: hepadnaviruses, and herpesviruses are examples of enveloped icosahedral DNA viruses.
  • Largest DNA viruses: Poxviruses: have complex internal symmetry

Types of RNA Viruses

  • Based on symmetry, some are enveloped and some naked.
    • Picornaviruses, caliciviruses, and reoviruses are RNA viruses without an envelope.
    • Reoviruses have double-stranded RNA; other RNA viruses have single-stranded RNA.
    • Reoviruses and influenza viruses have segmented RNA; the others have non-segmented RNA.
    • Picornaviruses, caliciviruses, flaviviruses, togaviruses, retroviruses, and coronaviruses have positive-polarity RNA, while others have negative-polarity RNA.

Other Important Viral Groups

  • Coronavirus
  • Togavirus
  • Retrovirus
  • Orthomyxovirus
  • Paramyxovirus
  • Rhabdovirus
  • Filovirus

Disease information

  • Viruses can cause various diseases, including the common cold, pneumonia, and other respiratory illnesses.
  • Specific viruses can cause diseases like SARS, MERS, and COVID-19.
  • Modes of transmission (airborne, direct contact, fecal-oral) differ among viruses.

Prevention, Treatment and Control

  • Prevention strategies (hand hygiene, vaccination) are important to contain virus spread.
  • Molecular tests (nucleic acid detection, serology) are used in diagnosing viral infections.
  • Vaccination is important for preventive measures.
  • Variants of viruses, notably SARS-CoV-2, can emerge over time, potentially with altered transmissibility and disease severity.

References

  • Various books on microbiology and virology, as listed in the supplementary slides.

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