Medical Important Viruses

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Questions and Answers

What are the two geometric configurations of capsid symmetry commonly found in virus families?

  • Spherical and Triangular
  • Helical and Square
  • Helical and Icosahedral (correct)
  • Icosahedral and Rectangular

What characterizes positive-strand RNA viruses?

  • Their RNA has messenger RNA sense, allowing it to act as a template for protein synthesis (correct)
  • They are double-stranded RNA viruses
  • They consist only of genetic material without a protein coat
  • Their RNA cannot be used as a template for protein synthesis

What is the term for the complex formed by polypeptides and viral nucleic acid in helical capsids?

  • Nucleocapsid (correct)
  • Capsomer
  • Genome
  • Capsid

How are capsomers in icosahedral viruses arranged?

<p>Grouped into structural subassemblies (D)</p> Signup and view all the answers

What differentiates single-stranded RNA genomes based on polarity?

<p>Their capacity to function as a template for protein synthesis (B)</p> Signup and view all the answers

What is a necessary component in the formation of helical capsids?

<p>Hydrogen bonding between protomers (B)</p> Signup and view all the answers

What type of viral genome is commonly found as double-stranded?

<p>dsDNA (C)</p> Signup and view all the answers

What property is NOT used to differentiate between genera and species within a virus family?

<p>Capsid shape (C)</p> Signup and view all the answers

What is the diameter of adenoviruses?

<p>75 nm (A)</p> Signup and view all the answers

Which type of virus is known for causing latent infections?

<p>Herpesviruses (D)</p> Signup and view all the answers

Hepatitis B virus belongs to which family of viruses?

<p>Hepadnaviruses (D)</p> Signup and view all the answers

What is unique about the DNA of hepadnaviruses?

<p>It is double-stranded and circular but incomplete. (A)</p> Signup and view all the answers

Which viruses are among the notable human pathogens in the herpesvirus family?

<p>Epstein-Barr virus and Varicella-zoster virus (B)</p> Signup and view all the answers

What is the primary shape of poxviruses?

<p>Bricklike (C)</p> Signup and view all the answers

Which of the following viruses are classified as naked icosahedral viruses?

<p>Adenoviruses and Picornaviruses (C)</p> Signup and view all the answers

Caliciviruses are characterized as being what size?

<p>38 nm (A)</p> Signup and view all the answers

What are the two primary components that make up a virus?

<p>Protein structure and a nucleic acid genome (C)</p> Signup and view all the answers

Which feature is NOT used to categorize viruses into families and genera?

<p>Host organism type (D)</p> Signup and view all the answers

Which type of virus is the smallest based on the provided information?

<p>Parvoviruses at approximately 20 nm (B)</p> Signup and view all the answers

What is the complete virus particle that comprises a genome and a capsid called?

<p>Virion (B)</p> Signup and view all the answers

Which statement best describes the pathogenicity of a virus?

<p>It is influenced by structural and functional characteristics. (A)</p> Signup and view all the answers

How can the size of viruses be best compared to the size of bacteria?

<p>Viruses are approximately 100- to 1000-fold smaller than cells. (A)</p> Signup and view all the answers

What property allows viruses to pass through filters that trap bacteria?

<p>Their small size compared to bacterial cells (B)</p> Signup and view all the answers

Which type of viral capsid symmetry is mentioned as a classification criterion?

<p>Helical (D)</p> Signup and view all the answers

Which of the following viruses is known as the only important human pathogen among rhabdoviruses?

<p>Rabies virus (A)</p> Signup and view all the answers

What is the primary characteristic that defines filoviruses?

<p>Helical nucleocapsid and pleomorphic structure (A)</p> Signup and view all the answers

Which virus emerged in 2020 and is responsible for causing COVID-19 disease?

<p>SARS-CoV-2 (D)</p> Signup and view all the answers

The term 'corona' in coronaviruses refers to which feature of these viruses?

<p>The halo of spikes on their surface (C)</p> Signup and view all the answers

Which virus has been placed in its own genus called hepevirus?

<p>Hepatitis E virus (B)</p> Signup and view all the answers

What is the main human pathogen associated with reoviruses?

<p>Rotavirus (B)</p> Signup and view all the answers

What is the fatality rate associated with SARS, as reported during the outbreak?

<p>9% (B)</p> Signup and view all the answers

What type of RNA do flaviviruses possess?

<p>Single-stranded positive-polarity RNA (A)</p> Signup and view all the answers

Which animals are recognized as reservoirs and intermediate hosts for SARS-CoV?

<p>Horseshoe bats and civet cats (D)</p> Signup and view all the answers

What viral disease is primarily caused by coronaviruses, notably in its milder form?

<p>The common cold (A)</p> Signup and view all the answers

Which group of viruses contains the rubella virus?

<p>Togaviruses (D)</p> Signup and view all the answers

Which virus is characterized by the reverse transcription of RNA into DNA?

<p>Human T-cell leukemia virus (HTLV) (B)</p> Signup and view all the answers

Which of the following statements about parainfluenza viruses is true?

<p>They represent important human pathogens. (C)</p> Signup and view all the answers

What is the primary characteristic of orthomyxoviruses?

<p>They have a helical nucleocapsid and eight segments of RNA. (A)</p> Signup and view all the answers

Which of the following viruses is primarily responsible for influenza?

<p>Influenza virus (C)</p> Signup and view all the answers

What type of viral genome do retroviruses possess?

<p>Single-stranded diploid RNA (D)</p> Signup and view all the answers

What is the primary mode of transmission of MERS to humans?

<p>Close contact with camels (B)</p> Signup and view all the answers

Which of the following statements about COVID-19 is correct?

<p>Most people recover from COVID-19 without special treatment (B)</p> Signup and view all the answers

What is another name for the MERS virus?

<p>Human coronavirus-EMC (A)</p> Signup and view all the answers

What percentage of people who contract COVID-19 become seriously ill?

<p>About 1 out of every 6 (C)</p> Signup and view all the answers

Which of the following symptoms is NOT commonly associated with COVID-19?

<p>Skin rash (C)</p> Signup and view all the answers

What unique characteristic does MERS-CoV have regarding its relation to other viruses?

<p>It is closely related to a bat coronavirus (D)</p> Signup and view all the answers

At which point did WHO declare COVID-19 a pandemic?

<p>March 11, 2020 (B)</p> Signup and view all the answers

Which group of individuals is at higher risk for serious illness from COVID-19?

<p>Older adults and people with underlying health conditions (B)</p> Signup and view all the answers

Flashcards

What is a virus?

An infectious agent composed of a genome (RNA or DNA, but not both) and a protein coat (capsid) that protects the genome.

What is a virion?

A complete, infectious virus particle that includes the genome, capsid, and sometimes an envelope.

What is viral replication?

The process by which a virus replicates within a host cell. This is a mandatory intracellular event.

What is a capsid?

A protein shell that surrounds and protects the viral genome.

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What is a viral envelope?

A lipid bilayer membrane that surrounds some viruses, helping them bind to host cells.

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What is pathogenicity?

The ability of a virus to cause disease in a host.

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How are viruses classified?

Groups of closely related viruses that share similar characteristics, such as genome type, replication strategy, capsid symmetry, and presence/absence of an envelope.

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What is virion size?

The size of a virus particle, typically measured in nanometers.

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Viral genera and species

The classification of viruses within a family based on factors like host range, serological reactions, amino acid sequences of viral proteins, and nucleic acid homology.

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Viral Genome

The genetic material of a virus, which can be either RNA or DNA, and can be single-stranded (ss) or double-stranded (ds).

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Positive-strand RNA virus

A single-stranded RNA virus whose genome can be directly translated into proteins by the host ribosomes.

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Negative-strand RNA virus

A single-stranded RNA virus whose genome is complementary to mRNA and must be transcribed into mRNA before protein synthesis.

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Capsid

The protein shell that surrounds the viral genome, protecting it and facilitating delivery into the host cell.

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Helical symmetry

A capsid shape characterized by a long, cylindrical structure, often found in viruses like paramyxoviruses.

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Icosahedral symmetry

A capsid shape characterized by a spherical structure with 20 triangular faces, often seen in viruses like adenoviruses.

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Capsomers

Subunits of the capsid, made of multiple protein molecules, that assemble to form the capsid.

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Adenoviruses

A family of viruses that are naked and icosahedral, with a double-stranded linear DNA genome. They are known for causing respiratory infections, including pharyngitis.

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Hepadnaviruses

A family of viruses with unusual DNA structure. They have a double-shelled structure with an icosahedral capsid covered by an envelope.

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Herpesviruses

A large family of enveloped viruses with an icosahedral nucleocapsid and double-stranded linear DNA. Known for their ability to cause latent infections.

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Poxviruses

A family of large, brick-shaped viruses with a complex capsid symmetry and an envelope. They are known for causing skin lesions, like smallpox.

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RNA Viruses

A diverse group of viruses that contain RNA as their genetic material. They include both naked and enveloped viruses, with various shapes and sizes.

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Picornaviruses

The smallest RNA viruses, with single-stranded, linear RNA within a naked icosahedral capsid. They are common causes of various infections.

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Caliciviruses

A family of naked viruses with an icosahedral capsid, single-stranded, linear RNA. They are responsible for various gastrointestinal infections.

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Latent Infections

These viruses are known for their ability to cause latent infections. They remain dormant in the host cell until the right conditions trigger their reactivation.

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Reoviruses

Naked viruses with two icosahedral capsid coats and 10 segments of double-stranded linear RNA.

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Flaviviruses

Enveloped viruses with an icosahedral capsid and single-stranded, linear, nonsegmented, positive-polarity RNA.

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Togaviruses

Enveloped viruses with an icosahedral capsid and single-stranded, linear, nonsegmented, positive-polarity RNA. They are divided into alphaviruses and rubiviruses.

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Retroviruses

Enveloped viruses with an icosahedral capsid and two identical strands of single-stranded, linear, positive-polarity RNA. They are known for 'reverse transcription' of RNA into DNA.

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Orthomyxoviruses

Enveloped viruses with a helical nucleocapsid and eight segments of linear, single-stranded, negative-polarity RNA. They have an affinity for mucins.

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Paramyxoviruses

Enveloped viruses with a helical nucleocapsid and single-stranded, linear, nonsegmented, negative-polarity RNA. They are not associated with orthomyxoviruses.

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Rotavirus

A virus that causes diarrhea, mainly in infants.

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Hepatitis E virus

A virus that causes hepatitis, a liver infection.

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What are Rhabdoviruses?

Bullet-shaped viruses with a helical nucleocapsid and a single-stranded, linear, nonsegmented, negative-polarity RNA. The term "rhabdo" refers to the bullet shape.

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What are Filoviruses?

Enveloped viruses with a helical nucleocapsid and single-stranded, linear, nonsegmented, negative-polarity RNA. They are long filaments with a thread-like appearance.

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What are Coronaviruses?

Enveloped viruses with a helical nucleocapsid and a single-stranded, linear, nonsegmented, positive-polarity RNA. They have a prominent halo of spikes protruding from the envelope.

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What is SARS?

A respiratory illness that emerged in China in 2002. It was characterized by atypical pneumonia and a high fatality rate.

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What is MERS?

A severe respiratory illness that emerged in the Middle East in 2012. Similar to SARS, it is caused by a coronavirus and can be fatal.

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What is COVID-19?

A respiratory illness caused by a coronavirus that emerged in 2020. It is highly contagious and can cause severe symptoms, including pneumonia and respiratory failure.

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What is a reservoir?

The natural reservoir for a virus, where it exists in nature and is not causing disease.

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What is SARS-CoV-2?

The viral strain that causes COVID-19, a highly contagious respiratory illness.

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What are the typical symptoms of COVID-19?

The most common symptoms of COVID-19 are fever, tiredness, and dry cough. Some patients may also experience aches and pains, nasal congestion, runny nose, sore throat or diarrhea.

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What are the severe symptoms of COVID-19?

Around 1 out of every 6 people (16%) who gets COVID-19 experiences more severe symptoms. They may develop difficulty breathing and require hospital care. Older individuals and those with underlying health conditions are at higher risk.

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What is the incubation period of COVID-19?

A period of time between exposure to a virus and the onset of symptoms. In COVID-19, it can range from 1 to 14 days, but typically lasts 6 days.

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What is a pandemic?

A disease outbreak that spreads rapidly worldwide. Pandemics typically occur when a new virus emerges that humans have little to no immunity to. COVID-19 is an example of a recent pandemic.

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What is the World Health Organization (WHO)?

A global health authority that monitors and investigates public health threats worldwide. WHO declared COVID-19 a pandemic on March 11, 2020.

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Study Notes

Medical Important Viruses

  • Viruses are infectious agents with two main components: a genome (RNA or DNA, but not both) and a protein capsid to protect the genome.
  • Some viruses have additional features like an envelope, a lipid bilayer with proteins, differentiating virus groups.
  • A complete virus particle is called a virion.
  • Viruses replicate within host cells through a complex process, which typically involves attachment to the host cell, penetration and uncoating, gene expression and replication, assembly, and release of new virions.
  • Viruses are significantly smaller than the cells they infect, typically ranging from 20 -300 nm in diameter.
  • Viruses generally pass through filters designed to trap bacteria.
  • Virus classification is based on genome type, replication strategy, capsid symmetry, and the presence/absence of an envelope.
  • Viral classification is organised into families, subfamilies, genera and species.
  • Viral genomes can be either RNA or DNA, single-stranded or double-stranded.
  • Viral capsids are typically either helical or icosahedral.
  • Some viruses have an envelope, derived from the host cell membrane.
  • Viruses can cause a variety of diseases, presenting a wide range of structural and functional characteristics, and different species within a group of viruses can produce distinctly different pathologies.
  • Different viral families and diseases covered are: Herpesviruses, Adenoviruses, Papovaviruses, Hepadnaviruses, Poxviruses, RNA viruses, etc.

Virus Structure

  • Viruses, from the smallest to the largest, vary in size and can overlap in size with some bacteria.
  • Viruses are significantly smaller than the cells they infect.
  • The smallest viruses, such as parvoviruses are approximately 20nm in diameter, while the largest viruses, such as poxviruses, are approximately 300nm in diameter.

Baltimore Classification of Medically Important Viruses

  • There are seven groups of viruses in the classification.
  • Group I: dsDNA viruses
  • Group II: ssDNA viruses
  • Group III: dsRNA viruses
  • Group IV: (+)ssRNA viruses
  • Group V: (-)ssRNA viruses
  • Group VI: (+)ssRNA reverse-transcribing viruses
  • Group VII: dsDNA reverse-transcribing viruses

Viral Replication

  • The steps of viral replication include attachment, penetration, uncoating, gene expression, replication, assembly, and release.
  • Different viruses utilize slightly different strategies, but the basic process remains similar across many viral types.

COVID-19

  • COVID-19 is a zoonotic disease caused by SARS-CoV-2.
  • The most common symptoms of COVID-19 are fever, tiredness, and dry cough.
  • Some people experience additional symptoms including body aches, nasal congestion, runny nose, sore throat, or diarrhea.
  • The virus has variants that cause outbreaks internationally.

Prevention of COVID-19

  • Washing hands with soap and water or sanitizer for at least 20 seconds is effective.
  • Avoiding close contact with sick individuals is crucial.
  • Covering mouth and nose with a mask when around others is a preventative measure.
  • Avoiding crowded places limits exposure to the virus.

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