10 Questions
What is the main action of histamine?
Increased vascular permeability and vasodilation of venules
Where is serotonin primarily sourced from?
Platelet granules
What are the main actions of serotonin?
Actions similar to histamine
What influences vasomotor phenomena, vascular permeability, chemotaxis, and pain in the inflammatory process?
Exogenous and endogenous mediators
What is the source of arachidonic acid derivatives such as prostaglandins and leucotrienes?
Cell-derived sources
Which of the following is an exogenous mediator of acute inflammation?
Peptides of E. coli
What is the main action of histamine?
Increased vascular permeability and vasodilation of venules
Where is serotonin (5-hydroxytryptamine) sourced from?
Platelet granules
Which of the following is an action of arachidonic acid derivatives?
Influencing vasomotor phenomena
What are the main sources of vasoactive amines?
Mast cell and platelet granules
Study Notes
Histamine and Serotonin
- Histamine plays a crucial role in vasodilation, increasing vascular permeability, and smooth muscle contraction.
- Serotonin (5-hydroxytryptamine) is primarily sourced from the enterochromaffin cells of the intestinal mucosa and the serotonergic neurons of the central nervous system.
Actions of Serotonin
- Serotonin causes vasoconstriction, reduces inflammation, and modulates pain perception.
Arachidonic Acid Derivatives
- Arachidonic acid derivatives, such as prostaglandins and leukotrienes, influence vasomotor phenomena, vascular permeability, chemotaxis, and pain in the inflammatory process.
- These derivatives are sourced from the cell membrane phospholipids.
Exogenous Mediator of Acute Inflammation
- Bradykinin is an exogenous mediator of acute inflammation.
Vasoactive Amines
- The main sources of vasoactive amines are mast cells, platelets, and enterochromaffin cells.
Test your knowledge of the mediators of acute inflammation with this quiz. Explore the role of exogenous and endogenous mediators, including vasoactive amines, arachidonic acid derivatives, and more.
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