Mechanism of Action of Macrolides
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Questions and Answers

What is the primary mechanism of action of Tigecycline?

  • Inhibition of DNA replication
  • Inhibition of metabolic pathways
  • Inhibition of cell wall synthesis
  • Inhibition of protein synthesis (correct)

Which bacteria are Tigecycline effective against?

  • Only Gram-positive bacteria
  • Only Gram-negative bacteria
  • Only anaerobic bacteria
  • Both Gram-positive and Gram-negative bacteria (correct)

What is the main advantage of Tigecycline over tetracyclines?

  • Acts specifically on Pseudomonas spp.
  • No risk of allergic reactions
  • Less toxic to the kidneys
  • Overcomes bacterial resistance mechanisms (correct)

How does Tigecycline compare to Vancomycin in terms of activity?

<p>Tigecycline is more effective against Gram-positive bacteria than Vancomycin (D)</p> Signup and view all the answers

Which of the following is a contraindication for using Tigecycline?

<p>Pregnancy (D)</p> Signup and view all the answers

What is the primary target of Fusidic acid in bacterial cells?

<p>Protein synthesis (C)</p> Signup and view all the answers

Which factor contributes to Fusidic acid's inhibition of protein synthesis?

<p>Forming a complex with ribosome and EF-G (D)</p> Signup and view all the answers

What distinguishes Tigecycline from tetracyclines in terms of resistance mechanisms?

<p>Resistance due to altered ribosomal binding site and efflux pumps acquisition only (A)</p> Signup and view all the answers

What adverse effect might be associated with Tigecycline use during tooth development in children?

<p>Tooth discoloration (C)</p> Signup and view all the answers

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