Macrolides: Mechanism of Action and Resistance
6 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the mechanism of action of macrolides?

  • Inhibition of DNA replication
  • Blocking of cell membrane transport
  • Reversible binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis (correct)
  • Inhibition of cell wall synthesis

    • Which of the following is a characteristic of macrolides' gastrointestinal absorption?

  • Rapid and complete absorption
  • Variable absorption (correct)
  • Poor absorption in acidic environment
  • Consistent and complete absorption

    • What is the mechanism of resistance to macrolides?

  • Alteration in cell membrane permeability (correct)
  • Enhanced efflux pumps
  • Increased production of beta-lactamase
  • Mutation in the 30S ribosomal subunit

    • What is a unique characteristic of azithromycin compared to other macrolides?

    <p>Better activity against Haemophilus</p> Signup and view all the answers

    What is a common adverse effect of macrolides?

    <p>Gastrointestinal disturbances</p> Signup and view all the answers

    What is a unique feature of clarithromycin?

    <p>It has a hydroxy metabolite</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser