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Questions and Answers
What is the cytotoxic step in the mechanism of action of cyclophosphamide?
What is the cytotoxic step in the mechanism of action of cyclophosphamide?
- Metabolism to active compounds
- Formation of hydroxylated intermediates
- Reaction with DNA (correct)
- Excretion in the urine
How are cyclophosphamide and ifosfamide primarily biotransformed in the liver?
How are cyclophosphamide and ifosfamide primarily biotransformed in the liver?
- To acrolein
- To toxic metabolites
- To phosphoramide mustard
- To hydroxylated intermediates (correct)
Which enzyme plays a primary role in the metabolism of ifosfamide?
Which enzyme plays a primary role in the metabolism of ifosfamide?
- CYP450 2E1
- CYP450 3A4 (correct)
- CYP450 1A2
- CYP450 2C9
What is the unique toxicity associated with both cyclophosphamide and ifosfamide?
What is the unique toxicity associated with both cyclophosphamide and ifosfamide?
Which compound is used to neutralize the toxic metabolites responsible for bladder toxicity?
Which compound is used to neutralize the toxic metabolites responsible for bladder toxicity?
Why are nitrosoureas like carmustine and lomustine primarily used in the treatment of brain tumors?
Why are nitrosoureas like carmustine and lomustine primarily used in the treatment of brain tumors?
What is the primary mechanism of action of nitrosoureas?
What is the primary mechanism of action of nitrosoureas?
In which type of cells is the cytotoxicity of nitrosoureas primarily expressed?
In which type of cells is the cytotoxicity of nitrosoureas primarily expressed?
What is the major excretory route for Dacarbazine and Temozolomide?
What is the major excretory route for Dacarbazine and Temozolomide?
Which drug does not require the CYP450 system for metabolic transformation?
Which drug does not require the CYP450 system for metabolic transformation?
What is responsible for the alkylating activity of MTIC (methyltriazenoimidazole carboxamide)?
What is responsible for the alkylating activity of MTIC (methyltriazenoimidazole carboxamide)?
Which drug is used in the treatment of brain tumors like glioblastomas and astrocytomas?
Which drug is used in the treatment of brain tumors like glioblastomas and astrocytomas?
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