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Questions and Answers
How are cyclophosphamide and ifosfamide cytotoxic?
How are cyclophosphamide and ifosfamide cytotoxic?
- After the generation of alkylating species (correct)
- Through direct binding to DNA
- By inhibiting protein synthesis
- By interfering with cell membrane functions
What is the role of cytochrome P450 (CYP450) in the mechanism of action of cyclophosphamide and ifosfamide?
What is the role of cytochrome P450 (CYP450) in the mechanism of action of cyclophosphamide and ifosfamide?
- Producing alkylating species (correct)
- Enhancing cell division
- Targeting specific cancer cell receptors
- Activating the immune system
In what types of neoplastic diseases are cyclophosphamide and ifosfamide commonly used?
In what types of neoplastic diseases are cyclophosphamide and ifosfamide commonly used?
- Lung cancer and brain tumors
- Colon cancer and prostate cancer
- Non-Hodgkin lymphoma and sarcoma (correct)
- Leukemia and pancreatic cancer
What is the primary mechanism by which cyclophosphamide and ifosfamide exert their cytotoxic effects?
What is the primary mechanism by which cyclophosphamide and ifosfamide exert their cytotoxic effects?
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How are cyclophosphamide and ifosfamide typically administered in cancer treatment?
How are cyclophosphamide and ifosfamide typically administered in cancer treatment?
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