5 Questions
How are cyclophosphamide and ifosfamide cytotoxic?
After the generation of alkylating species
What is the role of cytochrome P450 (CYP450) in the mechanism of action of cyclophosphamide and ifosfamide?
Producing alkylating species
In what types of neoplastic diseases are cyclophosphamide and ifosfamide commonly used?
Non-Hodgkin lymphoma and sarcoma
What is the primary mechanism by which cyclophosphamide and ifosfamide exert their cytotoxic effects?
Generating alkylating species
How are cyclophosphamide and ifosfamide typically administered in cancer treatment?
Intravenously as an infusion
Learn about the closely related alkylating agents cyclophosphamide and ifosfamide, their primary mechanisms, toxicities, and clinical applications in treating neoplastic diseases like non-Hodgkin lymphoma and breast cancer.
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