Cyclophosphamide and Ifosfamide Mechanisms and Clinical Use
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Questions and Answers

How are cyclophosphamide and ifosfamide cytotoxic?

  • After the generation of alkylating species (correct)
  • Through direct binding to DNA
  • By inhibiting protein synthesis
  • By interfering with cell membrane functions

    • What is the role of cytochrome P450 (CYP450) in the mechanism of action of cyclophosphamide and ifosfamide?

  • Producing alkylating species (correct)
  • Enhancing cell division
  • Targeting specific cancer cell receptors
  • Activating the immune system

    • In what types of neoplastic diseases are cyclophosphamide and ifosfamide commonly used?

  • Lung cancer and brain tumors
  • Colon cancer and prostate cancer
  • Non-Hodgkin lymphoma and sarcoma (correct)
  • Leukemia and pancreatic cancer

    • What is the primary mechanism by which cyclophosphamide and ifosfamide exert their cytotoxic effects?

    <p>Generating alkylating species</p> Signup and view all the answers

    How are cyclophosphamide and ifosfamide typically administered in cancer treatment?

    <p>Intravenously as an infusion</p> Signup and view all the answers

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