Mechanical Properties of Collagen - Strain
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Questions and Answers

What is the role of integrin in cellular function?

  • Promotes collagen breakdown
  • Enhances microfilament contraction
  • Aids in cell adhesion (correct)
  • Increases muscle tissue strength
  • Which component provides intercellular tensegrity through microfilaments of non-contractile actin/myosin?

  • Integrin
  • Collagen (correct)
  • Fibronectin
  • Glycosaminoglycans
  • How does collagen content vary across musculoskeletal tissues?

  • Tendons have the least collagen percentage
  • Collagen content is highest in bone tissue
  • Collagen is most abundant in cartilage
  • Collagen constitutes 1-2% of muscle tissue (correct)
  • What effect does aging have on collagen structure?

    <p>Increases intra and intermolecular collagen cross-linking</p> Signup and view all the answers

    Which molecule is responsible for the stability of the collagen structure?

    <p>All of thee mentioned</p> Signup and view all the answers

    During which phase of tissue healing does collagen deposition result in increased scar tensile strength to about 15% of normal tissue?

    <p>Proliferative phase</p> Signup and view all the answers

    What is the main matrix element of dense connective tissue?

    <p>Collagen fibers</p> Signup and view all the answers

    What stimulates capillary budding from healthy arterioles to form mature blood vessels during tissue healing?

    <p>Low oxygen levels</p> Signup and view all the answers

    Which type of collagen is the main component of reticular fibers?

    <p>Type III</p> Signup and view all the answers

    In which phase of tissue healing does fibroplasia occur, leading to scar formation?

    <p>Proliferative phase</p> Signup and view all the answers

    What characterizes the tensile strength of a wound during the fibroblastic repair phase?

    <p>Reaches about 15% of normal tissue strength</p> Signup and view all the answers

    What is the most common type of collagen in the human body?

    <p>Type I</p> Signup and view all the answers

    Which type of collagen forms the basal lamina in the body?

    <p>Type IV</p> Signup and view all the answers

    In dense connective tissue, what is crowded between the collagen fibers?

    <p>Fibroblasts</p> Signup and view all the answers

    What is the term used to describe the process of collagen fibers combining to form distinct waveforms or 'Crimp' to promote tissue stiffness?

    <p>Collagen crimping</p> Signup and view all the answers

    Excessive un-crimping of collagen fascicles will result in:

    <p>Permanent length changes</p> Signup and view all the answers

    What are the three external forces that can cause deformation in collagen?

    <p>Compression Force, Tensile Force, Shear Force</p> Signup and view all the answers

    Collagen compliance in tendons and ligaments is primarily a function of:

    <p>Crimp angle</p> Signup and view all the answers

    During the maturation-remodeling phase of tissue healing, what is the process that involves increased stress and strain resulting in collagen realignment and strength?

    <p>Inductive or Tissue Tension Theory</p> Signup and view all the answers

    What is the typical timeframe for collagen to reach about 20% of its normal strength during the maturation-remodeling phase?

    <p>3 weeks</p> Signup and view all the answers

    Which type of scar is typically present after 3-4 weeks in the maturation-remodeling phase?

    <p>Nonvascular, contracted, strong scar</p> Signup and view all the answers

    Which theory describes increased stress and strain leading to collagen realignment and strength during tissue healing?

    <p>Inductive or Tissue Tension Theory</p> Signup and view all the answers

    What is the definition of strain in the context of collagen?

    <p>The temporary elongation that occurs when an external force is applied</p> Signup and view all the answers

    What does stiffness refer to in terms of collagen?

    <p>The resistance to lengthening under lesser loads</p> Signup and view all the answers

    What term is used to describe the combination of viscosity and elasticity in collagen?

    <p>Viscoelasticity</p> Signup and view all the answers

    How does collagen respond to different rates of loading?

    <p>It reacts differently based on the speed of loading</p> Signup and view all the answers

    What does a tissue with increased viscosity demonstrate in terms of stress-strain slopes?

    <p>Steep slopes due to higher viscous stiffness</p> Signup and view all the answers

    What happens to collagen under a specific load applied over time?

    <p>It deforms</p> Signup and view all the answers

    When collagen deformation occurs over time, what happens to the internal stress within the collagen?

    <p>It decreases</p> Signup and view all the answers

    What is the term used to describe the phenomenon where a viscoelastic material shows different loading and unloading curves?

    <p>Hysteresis</p> Signup and view all the answers

    What does hysteresis represent in the context of a viscoelastic material?

    <p>Energy dissipation or loss during loading and unloading</p> Signup and view all the answers

    How does hysteresis change with cyclical loading on a tendon?

    <p>Decreases</p> Signup and view all the answers

    What causes pain when the viscoelastic properties of collagen have been exceeded?

    <p>Energy dissipation</p> Signup and view all the answers

    In what way does collagen respond to a constant load over time?

    <p>By deforming</p> Signup and view all the answers

    What is the term used to describe the reduction of internal forces in a tendon due to elongation under low load passive stretch?

    <p>Stress relaxation</p> Signup and view all the answers

    "The difference between the loading and unloading curve of a viscoelastic material represents:"

    <p>% Loss of energy</p> Signup and view all the answers

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