Collagen

Collagen Structure and Function

• The main function of collagen in tissues is to provide strength, structure, and elasticity.
• The primary chain of collagen has a general structure consisting of Gly-X-Y repeats, where X and Y are often proline and hydroxyproline.

Tertiary Structure of Tropocollagen

• The tertiary structure of Tropocollagen is a triple helix, stabilized by hydrogen bonds, ionic interactions, and hydrophobic forces.

Collagen Fiber Formation

• The formation of collagen fibers is led by the cross-linking of Tropocollagen molecules.

Genetic Disorders

• Osteogenesis Imperfecta, also known as Brittle Bone Disease, is a genetic disorder caused by mutations in collagen genes.
• Osteogenesis Imperfecta is characterized by high fragility of bones, leading to frequent fractures.

Vitamin Deficiency

• A deficiency in Vitamin C can lead to symptoms such as small hemorrhages, tooth loss, and poor wound healing.
• Vitamin C is required for the synthesis of hydroxyproline, a crucial component of collagen.

Collagen Types and Properties

• There are several types of collagen, differing in the number of cross-links between molecules.
• The rigidity or flexibility of collagen fibers depends on the organization and cross-linking of collagen molecules.

Collagen in Tissues

• Collagen is a main component of connective tissue, providing strength, structure, and elasticity.
• Collagen is the most abundant protein in mammals.