16 Questions
What is the main function of collagen in tissues?
Conferring flexibility and/or strength
What is the general structure of the primary chain of collagen?
Gly-X-Y repeated multiple times
What is the tertiary structure of Tropocollagen?
Right-handed helix formed by three amino acid residues per turn
What leads to the formation of Collagen fibers?
Assembling of tropocollagen fibers
What is the genetic disorder commonly known as Brittle Bone Disease?
Osteogenesis imperfecta
Which vitamin deficiency leads to symptoms like small hemorrhages, tooth loss, and poor wound healing?
Vitamin C
What is the main requirement for hydroxyproline synthesis?
Vitamin C
How many types of collagen differ based on the number of cross-links?
At least 27
What causes the high fragility of bones in Osteogenesis imperfecta?
A mutation affecting Collagen type I
What is the consequence of a lack of Vitamin C in the body?
General degeneration of connective tissue
What determines whether collagen fibers are more rigid or flexible?
The number of cross-links between tropocollagen fibers
What is the main cause of the malformation of collagen helix in Osteogenesis imperfecta?
A mutation affecting Collagen type I
What is the primary structure of collagen composed of?
Gly-X-Y triplets
Which tissue component is collagen a main component of?
Connective tissue
What is the tertiary structure of Tropocollagen?
Right-handed helix
What is the most abundant protein in mammals?
Collagen
Study Notes
Collagen Structure and Function
- The main function of collagen in tissues is to provide strength, structure, and elasticity.
- The primary chain of collagen has a general structure consisting of Gly-X-Y repeats, where X and Y are often proline and hydroxyproline.
Tertiary Structure of Tropocollagen
- The tertiary structure of Tropocollagen is a triple helix, stabilized by hydrogen bonds, ionic interactions, and hydrophobic forces.
Collagen Fiber Formation
- The formation of collagen fibers is led by the cross-linking of Tropocollagen molecules.
Genetic Disorders
- Osteogenesis Imperfecta, also known as Brittle Bone Disease, is a genetic disorder caused by mutations in collagen genes.
- Osteogenesis Imperfecta is characterized by high fragility of bones, leading to frequent fractures.
Vitamin Deficiency
- A deficiency in Vitamin C can lead to symptoms such as small hemorrhages, tooth loss, and poor wound healing.
- Vitamin C is required for the synthesis of hydroxyproline, a crucial component of collagen.
Collagen Types and Properties
- There are several types of collagen, differing in the number of cross-links between molecules.
- The rigidity or flexibility of collagen fibers depends on the organization and cross-linking of collagen molecules.
Collagen in Tissues
- Collagen is a main component of connective tissue, providing strength, structure, and elasticity.
- Collagen is the most abundant protein in mammals.
Test your knowledge of collagen with this quiz! Learn about the structure, function, and importance of collagen in connective tissues such as tendons, cartilage, and bone matrix. Dive into the amino acid sequence and understand the role of collagen in providing strength and flexibility to various tissues in the body.
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