Maximizing Bioavailability of Diclofenac Suppository

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Which type of drug delivery system is commonly used rectally and vaginally and occasionally urethrally?

Injections

Tablets

Capsules

Suppositories (correct)

What factor plays a significant role in the systemic absorption of lipophilic drugs through rectal drug delivery?

Absence of enzymes in the rectum

First-pass metabolism

Lymphatic drainage of the rectum (correct)

Carrier mediated transport

Which characteristic of the colon affects drug absorption according to the text?

Position of the formulation in the colon (correct)

Buffer capacity of the colon

Length of the colon

Presence of enzymes in the colon

Why is drug degradation relatively lower in the rectum compared to the upper part of the gastrointestinal tract?

Presence of enzymes in the rectum Signup and view all the answers

Which principle supports the idea that lipophilic drugs have better absorption through rectal drug delivery?

Like dissolves like principle Signup and view all the answers

What is a common feature of suppositories based on the provided text?

Tapered ends Signup and view all the answers

What factor governs the maximum concentration of a drug incorporated in a suppository unit?

Drug solubility in the rectal fluid Signup and view all the answers

Why are hydrophilic drugs recommended to be in solution form for suppository formulation?

High solubility in the suppository vehicle Signup and view all the answers

Why are W/O emulsion-type suppositories discouraged?

Slow transfer of drug molecules and retarded absorption Signup and view all the answers

In suppository bases, which choice represents a fatty base according to the given rules?

Low solubility in water, high solubility in fat Signup and view all the answers

Why is it recommended to incorporate drug particles in a suppository as fine or very fine powder?

To prevent sedimentation during or after preparation Signup and view all the answers

Which factor retards drug absorption and reduces bioavailability for a hydrophilic drug in suppository formulation according to the text?

Low drug release rate Signup and view all the answers

Which approach is recommended to enhance the bioavailability of the antipyretic drug in Product X® based on the 'like dissolves like' principle?

Using the ionized salt form of Diclofenac Signup and view all the answers

Why is using the salt form of Diclofenac suggested to enhance bioavailability in Product X®?

It readily partitions out of the cocoa butter base Signup and view all the answers

What physicochemical factor plays a crucial role in determining whether a product is in a solution or suspension form?

Drug lipid-water solubility Signup and view all the answers

How do water-miscible bases like glycerinated gelatin and PEG affect drug release compared to cocoa butter?

They dissolve instead of melt, leading to retarded drug release Signup and view all the answers

In the context of enhancing drug release from suppositories, why is drug solubility in the suppository base a critical factor?

Lower drug solubility allows for controlled release Signup and view all the answers

Which factor is NOT mentioned as a physicochemical consideration affecting drug release from suppositories?

Buffer capacity of the product Signup and view all the answers

Maximizing Bioavailability of Diclofenac Suppository

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