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Questions and Answers
Which type of drug delivery system is commonly used rectally and vaginally and occasionally urethrally?
Which type of drug delivery system is commonly used rectally and vaginally and occasionally urethrally?
- Injections
- Tablets
- Capsules
- Suppositories (correct)
What factor plays a significant role in the systemic absorption of lipophilic drugs through rectal drug delivery?
What factor plays a significant role in the systemic absorption of lipophilic drugs through rectal drug delivery?
- Absence of enzymes in the rectum
- First-pass metabolism
- Lymphatic drainage of the rectum (correct)
- Carrier mediated transport
Which characteristic of the colon affects drug absorption according to the text?
Which characteristic of the colon affects drug absorption according to the text?
- Position of the formulation in the colon (correct)
- Buffer capacity of the colon
- Length of the colon
- Presence of enzymes in the colon
Why is drug degradation relatively lower in the rectum compared to the upper part of the gastrointestinal tract?
Why is drug degradation relatively lower in the rectum compared to the upper part of the gastrointestinal tract?
Which principle supports the idea that lipophilic drugs have better absorption through rectal drug delivery?
Which principle supports the idea that lipophilic drugs have better absorption through rectal drug delivery?
What is a common feature of suppositories based on the provided text?
What is a common feature of suppositories based on the provided text?
What factor governs the maximum concentration of a drug incorporated in a suppository unit?
What factor governs the maximum concentration of a drug incorporated in a suppository unit?
Why are hydrophilic drugs recommended to be in solution form for suppository formulation?
Why are hydrophilic drugs recommended to be in solution form for suppository formulation?
Why are W/O emulsion-type suppositories discouraged?
Why are W/O emulsion-type suppositories discouraged?
In suppository bases, which choice represents a fatty base according to the given rules?
In suppository bases, which choice represents a fatty base according to the given rules?
Why is it recommended to incorporate drug particles in a suppository as fine or very fine powder?
Why is it recommended to incorporate drug particles in a suppository as fine or very fine powder?
Which factor retards drug absorption and reduces bioavailability for a hydrophilic drug in suppository formulation according to the text?
Which factor retards drug absorption and reduces bioavailability for a hydrophilic drug in suppository formulation according to the text?
Which approach is recommended to enhance the bioavailability of the antipyretic drug in Product X® based on the 'like dissolves like' principle?
Which approach is recommended to enhance the bioavailability of the antipyretic drug in Product X® based on the 'like dissolves like' principle?
Why is using the salt form of Diclofenac suggested to enhance bioavailability in Product X®?
Why is using the salt form of Diclofenac suggested to enhance bioavailability in Product X®?
What physicochemical factor plays a crucial role in determining whether a product is in a solution or suspension form?
What physicochemical factor plays a crucial role in determining whether a product is in a solution or suspension form?
How do water-miscible bases like glycerinated gelatin and PEG affect drug release compared to cocoa butter?
How do water-miscible bases like glycerinated gelatin and PEG affect drug release compared to cocoa butter?
In the context of enhancing drug release from suppositories, why is drug solubility in the suppository base a critical factor?
In the context of enhancing drug release from suppositories, why is drug solubility in the suppository base a critical factor?
Which factor is NOT mentioned as a physicochemical consideration affecting drug release from suppositories?
Which factor is NOT mentioned as a physicochemical consideration affecting drug release from suppositories?
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