18 Questions
Which type of drug delivery system is commonly used rectally and vaginally and occasionally urethrally?
Suppositories
What factor plays a significant role in the systemic absorption of lipophilic drugs through rectal drug delivery?
Lymphatic drainage of the rectum
Which characteristic of the colon affects drug absorption according to the text?
Position of the formulation in the colon
Why is drug degradation relatively lower in the rectum compared to the upper part of the gastrointestinal tract?
Presence of enzymes in the rectum
Which principle supports the idea that lipophilic drugs have better absorption through rectal drug delivery?
Like dissolves like principle
What is a common feature of suppositories based on the provided text?
Tapered ends
What factor governs the maximum concentration of a drug incorporated in a suppository unit?
Drug solubility in the rectal fluid
Why are hydrophilic drugs recommended to be in solution form for suppository formulation?
High solubility in the suppository vehicle
Why are W/O emulsion-type suppositories discouraged?
Slow transfer of drug molecules and retarded absorption
In suppository bases, which choice represents a fatty base according to the given rules?
Low solubility in water, high solubility in fat
Why is it recommended to incorporate drug particles in a suppository as fine or very fine powder?
To prevent sedimentation during or after preparation
Which factor retards drug absorption and reduces bioavailability for a hydrophilic drug in suppository formulation according to the text?
Low drug release rate
Which approach is recommended to enhance the bioavailability of the antipyretic drug in Product X® based on the 'like dissolves like' principle?
Using the ionized salt form of Diclofenac
Why is using the salt form of Diclofenac suggested to enhance bioavailability in Product X®?
It readily partitions out of the cocoa butter base
What physicochemical factor plays a crucial role in determining whether a product is in a solution or suspension form?
Drug lipid-water solubility
How do water-miscible bases like glycerinated gelatin and PEG affect drug release compared to cocoa butter?
They dissolve instead of melt, leading to retarded drug release
In the context of enhancing drug release from suppositories, why is drug solubility in the suppository base a critical factor?
Lower drug solubility allows for controlled release
Which factor is NOT mentioned as a physicochemical consideration affecting drug release from suppositories?
Buffer capacity of the product
Learn how to maximize the bioavailability of an antipyretic drug suppository containing Diclofenac by applying the principle of 'like dissolves like'. Understand why matching the drug properties with suppository components can optimize drug release and absorption.
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